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Dequalinium vaginal tablets and preparation method thereof

A technology of dequalinium chloride and vaginal tablets, which is applied in the directions of medical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problem of unpublished reports on the development of dequalinium chloride vaginal tablets and the unknown Problems such as the vaginal tablets of dequalinium chloride have achieved low cost, stable product quality, and rapid onset of effect

Inactive Publication Date: 2016-09-07
ANHUI YIXINMING PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Scholars at home and abroad have not published reports on the development of dequalinium vaginal tablets, and there is no known example of actually manufacturing vaginal tablets containing dequalinium chloride

Method used

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  • Dequalinium vaginal tablets and preparation method thereof
  • Dequalinium vaginal tablets and preparation method thereof
  • Dequalinium vaginal tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 dequalinium chloride vaginal tablet

[0029] prescription:

[0030]

[0031] Preparation Process:

[0032] 1. Grinding: Use a turbo self-cooling dust-free pulverizer to pulverize dequalinium chloride with a No. 6 sieve, and pass through a 80-mesh sieve, and pass the rest of the auxiliary materials through a 80-120-mesh sieve for subsequent use;

[0033] ② Mixing: Add dequalinium chloride, lactose monohydrate and 80% prescription microcrystalline cellulose to the pot of the high-efficiency wet mixing granulator in sequence, and mix the materials for 10 minutes with a slow-speed stirring paddle and a slow-speed chopping knife ,well mixed;

[0034] ③. Wet granulation: Put the mixing blade and chopping blade of the granulator on the fast device, add 70% ethanol solution to the mixture, and mix the wet mixture for 5 minutes to make a suitable soft material. Then use a swinging granulator to make suitable granules with a 20-mesh sieve;

...

Embodiment 2

[0040] The preparation of embodiment 2 dequalinium chloride vaginal tablet

[0041] prescription:

[0042]

[0043] Preparation Process:

[0044] 1. Grinding: Use a turbo self-cooling dust-free pulverizer to pulverize dequalinium chloride with a No. 6 sieve, and pass through a 80-mesh sieve, and pass the rest of the auxiliary materials through a 80-120-mesh sieve for subsequent use;

[0045] ② Mixing: Add dequalinium chloride, lactose monohydrate and 80% prescription microcrystalline cellulose to the pot of the high-efficiency wet mixing granulator in sequence, and mix the materials for 10 minutes with a slow-speed stirring paddle and a slow-speed chopping knife ,well mixed;

[0046] ③. Wet granulation: Put the mixing blade and chopping blade of the granulator on the fast device, add 70% ethanol solution to the mixture, and mix the wet mixture for 5 minutes to make a suitable soft material. Then use a swinging granulator to make suitable granules with a 20-mesh sieve;

...

Embodiment 3

[0052] Embodiment 3 Determination of disintegration time limit

[0053] Get 6 25 ml measuring cylinders, add water 3ml respectively, put in a 37C constant temperature water bath, after the constant temperature, drop into 1 tablet of the present invention respectively (the tablet is wound into a net shape with No. 22 lead wire with a length of 16cm), and start to record the time. Complete disintegration within minutes.

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Abstract

The invention discloses dequalinium vaginal tablets and a preparation method thereof. Each dequalinium vaginal tablet comprises, by weight, 10mg of dequalinium, 50-100mg of lactose monohydrate, 25-50mg of microcrystalline cellulose and 1-3mg of magnesium stearate. The preparation method which uses the production equipment of common tablets is simple in process and low in cost. The dequalinium vaginal tablets have the advantages that the tablets are fast in disintegration and quick in action, patients accept the tablets with pleasure, and the like.

Description

technical field [0001] The invention relates to a dequalinium chloride vaginal tablet for treating mold, bacteria and trichomonas mixed vaginitis and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Mixed vaginitis refers to the inflammatory lesions caused by vaginal infection caused by various germs (such as mold, bacteria, trichomonas, etc.) and protozoa, which is also the local manifestation of vaginal flora imbalance. Most of them are mixed infections, such as viral infections secondary to bacterial infections or after treatment. The clinical manifestations of mixed infection are different, and the severity is different. The diagnosis mainly depends on the culture and identification of the laboratory. The main principle of vaginitis treatment is: eliminate the incentive, choose local or systemic application of antifungal drugs according to the patient's condition, antifungal drugs should be comb...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K31/4709A61P31/10A61P31/04A61P33/02A61P15/02
CPCA61K9/2054A61K9/0034A61K31/4709
Inventor 徐奎曽飞李璐昊王会山
Owner ANHUI YIXINMING PHARMA TECH
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