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A kind of pharmaceutical composition for treating simple obesity and use thereof

A composition and obesity technology, applied in the direction of drug combination, active ingredients of heterocyclic compounds, medical preparations containing active ingredients, etc., can solve the problems of high toxicity and side effects

Active Publication Date: 2018-06-05
GUANGZHOU CARDLO BIOCHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Lorcaserin has a certain therapeutic effect in the treatment of simple obesity, but because it is a centrally acting weight loss drug, it still has high toxic and side effects. How to reduce its toxic and side effects and enhance its weight loss effect has become an important issue in the field of medicine. A problem that needs attention, and effectively solving this problem will surely bring good news to more obese patients

Method used

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  • A kind of pharmaceutical composition for treating simple obesity and use thereof
  • A kind of pharmaceutical composition for treating simple obesity and use thereof
  • A kind of pharmaceutical composition for treating simple obesity and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The preparation of embodiment 1 compound tablet

[0014]

[0015]

[0016] Preparation process: Weigh the prescribed amount of lorcaserin, sucrose fatty acid ester, starch, and microcrystalline cellulose and mix evenly. In addition, add an appropriate amount of 15% starch slurry to the mixed powder, mix evenly, make soft material, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 2

[0017] The preparation of embodiment 2 compound tablet

[0018]

[0019] Preparation process: the preparation method is the same as in Example 1 except that the auxiliary materials are different. .

Embodiment 3

[0021]

[0022] Preparation process: Lorcaserin passes through a 100-mesh sieve, hydroxypropyl cellulose-4M, and microcrystalline cellulose pass through a 80-mesh sieve, and the prescribed amount of lorcaserin, hydroxypropyl cellulose-4M, and microcrystalline cellulose are weighed Mix the ingredients evenly, add an appropriate amount of 8% PVP absolute ethanol solution to granulate, dry at 60°C, sieve the dry granules with a 16-mesh sieve, and add the prescribed amount of magnesium stearate to the dry granules.

[0023]

[0024]

[0025] Preparation process: sucrose fatty acid ester is passed through a 100-mesh sieve, sodium carboxymethylcellulose and lactose are passed through a 80-mesh sieve, the recipe amount of sucrose fatty acid ester, sodium carboxymethylcellulose and lactose is weighed and mixed evenly, and 6% PVP is added An appropriate amount of 95% ethanol solution is granulated, dried at 60° C., and the dry granules are sieved with a 16 mesh sieve, and the m...

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Abstract

The invention relates to a medicinal composition for treating simple obesity and application of the medicinal composition, in particular to a medicinal composition which takes lorcaserin and sucrose fatty acid ester as active medicinal components. Lorcaserin has a remarkable effect in treating simple obesity, but is relatively large in adverse reaction; on the basis, lorcaserin and the sucrose fatty acid ester are creatively combined to prepare the medicinal composition for treating simple obesity, and the ratio of lorcaserin to sucrose fatty acid ester is 1:(0.1-100). With the combination of the two components, the clinical dosage of a single medicine is reduced, so that the toxic and side effect of the medicine is reduced, the treatment effect is improved, and thus the medicinal composition has an important clinical treatment significance.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating simple obesity and its application, in particular to a pharmaceutical composition with lorcaserin and sucrose fatty acid ester as active ingredients. Background technique [0002] Obesity is a chronic disease. According to the estimation of the World Health Organization, it is the most neglected disease facing mankind at present, but the incidence rate is rising sharply. Besides humans, many pets also suffer from obesity. Mammals (including humans) store fat so much that their health suffers. Obesity is a common and ancient cluster of metabolic disorders. When the human body eats more calories than it consumes, the excess calories are stored in the body in the form of fat, which exceeds the normal physiological requirements, and when it reaches a certain value, it becomes obesity. Normal adult adipose tissue accounts for 15% to 18% of body weight in males and 20% to 25% in females. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/55A61K31/7024A61P3/04A61P3/00
CPCA61K31/55A61K31/7024A61K2300/00
Inventor 徐怀义
Owner GUANGZHOU CARDLO BIOCHEM TECH
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