Therapeutic or preventive agent for multiple sclerosis

A general formula, hydrogen atom technology, applied in the direction of organic active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of no record of drug efficacy data, no indication of usefulness for multiple sclerosis, etc., to achieve The effect of suppressing the worsening of symptoms

Active Publication Date: 2019-04-09
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although it is reported in Patent Document 1 as a low-molecular compound having thrombin inhibitory activity, its usefulness for multiple sclerosis is not shown, and no specific pharmacodynamic data are described at all.

Method used

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  • Therapeutic or preventive agent for multiple sclerosis
  • Therapeutic or preventive agent for multiple sclerosis
  • Therapeutic or preventive agent for multiple sclerosis

Examples

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Embodiment

[0104] Hereinafter, although this invention is demonstrated concretely based on an Example, this invention is not limited to these.

[0105] (Evaluation of cyclohexane derivative (I) or its pharmacologically acceptable salt at 30 mg / kg in MOG-induced mouse experimental autoimmune encephalomyelitis model)

[0106] The effects of cyclohexane derivatives (I) or pharmacologically acceptable salts thereof on the increase of neurological symptom scores in mouse experimental autoimmune encephalomyelitis models induced by MOG were evaluated. A mouse experimental autoimmune encephalomyelitis model was prepared by partially modifying the method described in Journal of Neuroscience Research, 2006, volume 84, p.1225-1234.

[0107] The PBS solution containing the partially synthesized peptide of MOG adjusted to a concentration of 4 mg / mL (MOG35-55; CS Bio) and Freund's complete adjuvant were mixed in equal amounts, and the MOG35-55 administration solution thus obtained was injected into th...

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Abstract

An object of the present invention is to provide a therapeutic or preventive agent for multiple sclerosis comprising a non-steroidal low-molecular-weight compound as an active ingredient. The present invention provides a therapeutic or preventive agent for multiple sclerosis comprising, as an active ingredient, a cyclohexane derivative represented by the following or a pharmacologically acceptable salt thereof.

Description

technical field [0001] The present invention relates to therapeutic or preventive agents for multiple sclerosis. Background technique [0002] Multiple sclerosis is characterized by the destruction of the myelin sheath covering nerve fibers such as the brain, spinal cord, and optic nerves, resulting in demyelination, and is a disease in which the damage gradually increases while relapses and remissions are repeated. Symptoms vary depending on the site of the lesion, and it is known that various neurological symptoms such as visual impairment, quadriplegia, sensory impairment, and walking impairment appear (Non-Patent Document 1). [0003] As therapeutic drugs for multiple sclerosis, corticosteroids (steroids) are used for acute treatment, and interferon β-1b and interferon β-1a are used for recurrence prevention (Non-Patent Document 2). [0004] In addition, it is known that in multiple sclerosis, the coagulation system is hyperactive, and that hirudin, which is a thrombin ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/415A61K31/421A61K31/426A61K31/4439A61P25/00
CPCA61K31/421A61K31/426A61K31/4439A61K31/415A61P25/00A61P25/28A61K9/0053
Inventor K.高垣戒能美枝广川广绘
Owner TORAY IND INC
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