Method for preparing L-tetrahydropalmatine sulfate from Stephania kwangsiensis

A Tetrahydropalmatine Sulfate and ground-incompatible technology, which is applied in the field of biomedicine preparation, can solve the problems of consumption of large acid and alkali solutions, severe environmental pollution, etc., and achieve the effect of easy removal of impurities and reduction of pollution

Active Publication Date: 2016-09-21
NANNING GODSEND BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The invention provides a method for preparing L-tetrahydropalmatine sulfate in Guangxi to solve the problem that the traditional extraction of L-tetrahydropalmatine uses acid extraction and alkali precipitation, then extraction with an organic solvent, and finally crystallization treatment. The whole process needs Consumption of a large amount of acid and alkali solutions, serious environmental pollution and other issues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A method for preparing L-tetrahydropalmatine sulfate from Guangxi Dirong comprises the following steps:

[0027] S1: Crush 100kg of Guangxi Dirong medicinal materials to 40 meshes, put them into a percolation container, add 2% dilute sulfuric acid with a volume of 500L and soak for 28 hours, then start to release percolation liquid at a flow rate of 100L / hour, collect percolation liquid, and collect During the percolation process, new dilute sulfuric acid needs to be continuously added until the collected percolation solution reacts with the silicotungstic acid reagent and does not show alkaloid reaction characteristics.

[0028] S2: Pass the percolation solution obtained in step S1 through an ultrafiltration separation membrane with a molecular weight of 1000 Daltons to obtain a permeate, then pass through a reverse osmosis membrane with a molecular weight of 150 Daltons to obtain a reverse osmosis concentrate, and add 500L of deionized water Concentrate, collect 100L ...

Embodiment 2

[0033] A method for preparing L-tetrahydropalmatine sulfate from Guangxi Dirong comprises the following steps:

[0034] S1: Crush 100kg of Guangxi Dirong medicinal materials to 30 meshes, put them into a percolation container, add 2% dilute sulfuric acid with a volume of 500L and soak for 20 hours, then start to release percolation liquid at a flow rate of 100L / hour, collect percolation liquid, and collect During the percolation process, new dilute sulfuric acid needs to be continuously added until the collected percolation solution reacts with the silicotungstic acid reagent and does not show alkaloid reaction characteristics.

[0035] S2: Pass the percolation solution obtained in step S1 through an ultrafiltration separation membrane with a molecular weight of 1000 Daltons to obtain a permeate, then pass through a reverse osmosis membrane with a molecular weight of 150 Daltons to obtain a reverse osmosis concentrate, and add 500L of deionized water Concentrate, collect 100L ...

Embodiment 3

[0040] A method for preparing L-tetrahydropalmatine sulfate from Guangxi Dirong comprises the following steps:

[0041] S1: Crush 200kg of Guangxi Dirong medicinal materials to 10 meshes, put them into a percolation container, add 2% dilute sulfuric acid with a volume of 500L and soak for 24 hours, then start to release percolation liquid at a flow rate of 200L / hour, collect percolation liquid, and collect During the percolation process, new dilute sulfuric acid needs to be continuously added until the collected percolation solution reacts with the silicotungstic acid reagent and does not show alkaloid reaction characteristics.

[0042] S2: Pass the percolation solution obtained in step S1 through an ultrafiltration separation membrane with a molecular weight of 1000 Daltons to obtain a permeate, then pass through a reverse osmosis membrane with a molecular weight of 150 Daltons to obtain a reverse osmosis concentrate, and add 1000L deionized water Concentrate, collect 200L of...

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Abstract

The invention discloses a method for preparing L-tetrahydropalmatine sulfate from Stephania kwangsiensis and belongs to the field of biomedicine. The method comprises the steps of extracting, separating, purifying, crystallizing and the like. Ultrafiltration and reverse osmosis membrane separation techniques are used in the method, mass acid is reused, and environmental pollution is reduced; through a membrane molecular weight of selective separation, impurities are easy to remove, and it is easier to prepare high-quality L-tetrahydropalmatine sulfate.

Description

【Technical field】 [0001] The invention belongs to the technical field of biomedicine preparation, and in particular relates to a method for preparing L-tetrahydropalmatine sulfate from Guangxi. 【Background technique】 [0002] Guangxi Dirong (scientific name: Stephania kwangsiensis) is a plant of the genus Stephaniaceae, which is endemic to China. According to the existing research results, it has been shown that the alkaloid components in Guangxi Dicong contain kebanine, dehydrokebanine, oxocarbanine, tetrahydropalmatine, palmatine, 1-corydalis monophenolic alkaloids, and isoscurin Active ingredients such as lycine, d-stiphenine, homoamoreline, tetrandrine, stephenine, qingfengjing, fangchinoline and so on. Tetrahydropalmatine (Tetrahydropalmatine) is a highly active alkaloid. Modern pharmacological studies have shown that it can inhibit the nerve center, and has analgesic, sedative, hypnotic, and tranquilizing effects; powerful. Its hypnotic effect occurs 15 minutes afte...

Claims

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Application Information

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IPC IPC(8): C07D455/03
CPCC07D455/03
Inventor 阮俊唐桂英
Owner NANNING GODSEND BIOTECH
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