Borneol camphor essential oil slow-release cream for curing acne vulgaris and preparation method thereof
A technology of camphor essential oil and cream, which is applied in the field of slow-release cream for treating acne vulgaris and its preparation, can solve the problems of local sensitive skin irritation, overcome antibiotic resistance, delay the release of essential oil components, and increase firmness. sexual effect
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Embodiment 1
[0041] Embodiment 1 The preparation of borneol camphor essential oil sustained-release cream
[0042] According to the influencing factors of the orthogonal test, the cream prescription is further optimized, and is composed of the following raw materials by weight ratio: 2 g of borneol camphor essential oil, 20 g of castor oil, 15 g of liquid paraffin, and 3 g of PEG-30 dipolyhydroxystearate , Glyceryl Monoisostearate 3g, EDTA -2Na 0.05g, Glycerin 10g, Purified Water 46.95g.
[0043] Prepare above-mentioned emulsifiable paste, adopt emulsification method in water. Weigh the prescribed amount of purified water, EDTA-2Na, and glycerin as the water phase, and additionally take the prescribed amount of borneol camphor essential oil, castor oil, liquid paraffin, PEG-30 dipolyhydroxystearate, glycerol monoisostearate The ester is the oil phase, put the two in a suitable container, heat to dissolve or disperse, and keep the temperature at about 80°C, slowly add the oil phase to the ...
Embodiment 2
[0044] Embodiment 2 The preparation of borneol camphor essential oil sustained-release cream
[0045] According to the influencing factors of the orthogonal test, the cream prescription is further optimized, and is composed of the following raw materials by weight ratio: 4 g of borneol camphor essential oil, 18 g of castor oil, 15 g of liquid paraffin, and 3 g of PEG-30 dipolyhydroxystearate , Glyceryl Monoisostearate 3g, EDTA -2Na 0.05g, Glycerin 10g, Purified Water 48.95g.
[0046] Prepare above-mentioned emulsifiable paste, adopt emulsification method in water. Weigh the prescribed amount of purified water, EDTA-2Na, and glycerin as the water phase, and additionally take the prescribed amount of borneol camphor essential oil, castor oil, liquid paraffin, PEG-30 dipolyhydroxystearate, glycerol monoisostearate The ester is the oil phase, put the two in a suitable container, heat to dissolve or disperse, and keep the temperature at about 70°C, slowly add the oil phase to the ...
Embodiment 3
[0047] Example 3 The investigation of the in vitro release rate of sustained-release cream
[0048] Method: Take healthy mice and use 8% Na 2 The S solution was used to remove the hair, and the neck was cut to death. The skin on the back was taken, the subcutaneous fat tissue and adhesions were scraped off, rinsed with distilled water, and soaked in normal saline for 30 minutes for later use. Using an in vitro intelligent transdermal tester, fix the spare mouse skin between the supply chamber and the receptor chamber of the diffusion cell, so that the cuticle faces the supply chamber, accurately weigh 0.1g of the sample, place it in the supply chamber, spread it evenly, and contact with the skin , constant temperature at 37°C, 100 r / min constant speed magnetic stirring, sample 1ml at 1h, 2h, 4h, 8h, 12h, 24h, and 72h, and add an equal volume of receiving solution at the same time. The samples were determined by GC / MS to measure the content of natural d-borneol, a representati...
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