Borneol camphor essential oil slow-release cream for curing acne vulgaris and preparation method thereof

A technology of camphor essential oil and cream, which is applied in the field of slow-release cream for treating acne vulgaris and its preparation, can solve the problems of local sensitive skin irritation, overcome antibiotic resistance, delay the release of essential oil components, and increase firmness. sexual effect

Inactive Publication Date: 2016-09-28
HANGZHOU SHUIMU BORNYL BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, most plant essential oils themselves have a penetration-promoting effect. On the one hand, while promoting the penetration of active ingredients into the skin, they may also cause i...

Method used

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  • Borneol camphor essential oil slow-release cream for curing acne vulgaris and preparation method thereof
  • Borneol camphor essential oil slow-release cream for curing acne vulgaris and preparation method thereof
  • Borneol camphor essential oil slow-release cream for curing acne vulgaris and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 The preparation of borneol camphor essential oil sustained-release cream

[0042] According to the influencing factors of the orthogonal test, the cream prescription is further optimized, and is composed of the following raw materials by weight ratio: 2 g of borneol camphor essential oil, 20 g of castor oil, 15 g of liquid paraffin, and 3 g of PEG-30 dipolyhydroxystearate , Glyceryl Monoisostearate 3g, EDTA -2Na 0.05g, Glycerin 10g, Purified Water 46.95g.

[0043] Prepare above-mentioned emulsifiable paste, adopt emulsification method in water. Weigh the prescribed amount of purified water, EDTA-2Na, and glycerin as the water phase, and additionally take the prescribed amount of borneol camphor essential oil, castor oil, liquid paraffin, PEG-30 dipolyhydroxystearate, glycerol monoisostearate The ester is the oil phase, put the two in a suitable container, heat to dissolve or disperse, and keep the temperature at about 80°C, slowly add the oil phase to the ...

Embodiment 2

[0044] Embodiment 2 The preparation of borneol camphor essential oil sustained-release cream

[0045] According to the influencing factors of the orthogonal test, the cream prescription is further optimized, and is composed of the following raw materials by weight ratio: 4 g of borneol camphor essential oil, 18 g of castor oil, 15 g of liquid paraffin, and 3 g of PEG-30 dipolyhydroxystearate , Glyceryl Monoisostearate 3g, EDTA -2Na 0.05g, Glycerin 10g, Purified Water 48.95g.

[0046] Prepare above-mentioned emulsifiable paste, adopt emulsification method in water. Weigh the prescribed amount of purified water, EDTA-2Na, and glycerin as the water phase, and additionally take the prescribed amount of borneol camphor essential oil, castor oil, liquid paraffin, PEG-30 dipolyhydroxystearate, glycerol monoisostearate The ester is the oil phase, put the two in a suitable container, heat to dissolve or disperse, and keep the temperature at about 70°C, slowly add the oil phase to the ...

Embodiment 3

[0047] Example 3 The investigation of the in vitro release rate of sustained-release cream

[0048] Method: Take healthy mice and use 8% Na 2 The S solution was used to remove the hair, and the neck was cut to death. The skin on the back was taken, the subcutaneous fat tissue and adhesions were scraped off, rinsed with distilled water, and soaked in normal saline for 30 minutes for later use. Using an in vitro intelligent transdermal tester, fix the spare mouse skin between the supply chamber and the receptor chamber of the diffusion cell, so that the cuticle faces the supply chamber, accurately weigh 0.1g of the sample, place it in the supply chamber, spread it evenly, and contact with the skin , constant temperature at 37°C, 100 r / min constant speed magnetic stirring, sample 1ml at 1h, 2h, 4h, 8h, 12h, 24h, and 72h, and add an equal volume of receiving solution at the same time. The samples were determined by GC / MS to measure the content of natural d-borneol, a representati...

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Abstract

The invention belongs to the technical field of pharmaceutical production, discloses plant essential oil having an anti-acne activity, and provides slow-release cream prepared from the essential oil and a preparation method of the slow-release cream. The slow-release cream is prepared from active ingredients of the plant essential oil extracted from a new variety of plant, namely borneol camphor tree, and is matched auxiliary material matrixes including castor oil, liquid paraffin, PEG-30 dipolyhydroxystearate, glyceryl monostearate, EDTA-2Na, glycerol and water. Compared with the prior art, the borneol camphor essential oil has novel ingredients and mild efficacy, the prepared slow-release cream has the characteristics of being long-lasting in effect, small in toxic or side effects, convenient for a user to use and the like, and the clinical effects of the acne cream is effectively guaranteed.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical production, and relates to a slow-release cream for treating acne vulgaris and a preparation method thereof. Background technique [0002] Acne (Acne) mainly occurs in sebum-rich parts such as the face, back, and chest. It is a chronic inflammatory lesion of hair follicles and sebaceous gland units related to abnormal sebum metabolism. Epidemiological surveys in recent years have shown that among people aged 14 to 45, 48.2% have mild acne, 24.2% have moderate acne, and 27.6% have severe acne. Acne vulgaris predominates. If it is not treated in time or prevented properly, long-term acne will not only cause permanent scars on the patient's face, but also have a serious negative impact on the patient's psychology and life. [0003] The pathological mechanism of acne is closely related to factors such as abnormal androgen metabolism, blockage of pilosebaceous gland duct, bacterial microbial i...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/44A61K47/14A61K47/10A61K47/18A61K36/54A61P17/10
CPCA61K9/0002A61K9/0014A61K9/06A61K36/54A61K47/10A61K47/14A61K47/183A61K47/44
Inventor 王士群史龙楼天伟黄昱俊宋大勇
Owner HANGZHOU SHUIMU BORNYL BIOTECH CO LTD
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