A kind of preparation method of high-purity lubiprostone compound

A technology for lubiprostone and compound is applied in the field of preparation of high-purity lubiprostone compound, can solve the problems of complicated operation, low yield, long steps and the like, and achieves the effect of simplifying production process and high reaction total yield
CN105985309BActive Publication Date: 2020-05-05NANJING CHIA TAI TIANQING PHARMA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING CHIA TAI TIANQING PHARMA
Publication Date
2020-05-05

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Abstract

The invention belongs to the technical field of medicine, and provides a high-purity lubiprostone compound and a preparation method thereof. According to the method, a LB-2 is taken as a raw material, then is subjected to oxidation and hydrogenation reactions, and then is processed to obtain the high-purity lubiprostone compound, wherein the oxidation reaction employs a dess-martin oxidizing agent, and the hydrogenation reaction is one-step hydrogenation. According to the invention, the production process is simplified, overall yield of the reaction is high, and the high-purity lubiprostone compound is prepared.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to a preparation method of a high-purity lubiprostone compound. Background technique

[0002] Lubiprostone is a prostaglandin derivative, which is a selective chloride ion channel activator, which can selectively activate the type 2 chloride ion channel (CIC-2) located on the luminal cell membrane of the apex of the gastrointestinal tract epithelium, and increase the secretion of intestinal fluid. Secretion and motility of the intestine, thereby increasing defecation, reducing symptoms of chronic idiopathic constipation, without changing the concentration of sodium and potassium in plasma. It has a novel mechanism of action and excellent clinical effects.

[0003] Lubiprostone has the following structure:

[0004] It exists in tautomers

[0005] European patent application EP0503887A2 discloses a method for synthesizing lubiprostone. The method uses cree diol as a raw material...

Claims

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