Dental ulcer gargle and preparation method thereof

A technology for oral ulcers and gargles, which is applied in the field of drug preparation, can solve the problems of poor curative effect and slow effect, and achieve the effect of non-toxic side effects and promoting coagulation of bleeding

Inactive Publication Date: 2016-10-12
LANJIATANG BIOLOGICAL MEDICINE FUJIAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The application date is: July 17, 2015. The Chinese invention patent with the publication number CN104940392 discloses "a gargle for the treatment of oral ulcers". Points, slow effect, poor curative effect

Method used

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  • Dental ulcer gargle and preparation method thereof
  • Dental ulcer gargle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A mouth ulcer gargle, comprising the following components by weight: 1 part of maltodextrin, 0.2 part of sodium carboxymethylcellulose, 0.5 part of carbomer, 0.05 part of trisodium citrate, and 0.005 part of mint essence , 0.005 parts of sodium saccharin, 0.1 parts of glycerin, 0.09 parts of sodium chloride, 0.01 parts of potassium hydroxide and 67 parts of purified water.

[0017] A mouth ulcer gargle, comprising the following components by weight: 1-15 parts of maltodextrin, 1 part of sodium carboxymethylcellulose, 1 part of carbomer, 1 part of trisodium citrate, and mint essence 0.008 parts, 0.008 parts of sodium saccharin, 5 parts of glycerin, 1 part of sodium chloride, 0.4 parts of potassium hydroxide and 80 parts of purified water.

[0018] A mouth ulcer gargle, comprising the following components by weight: 15 parts of maltodextrin, 2 parts of sodium carboxymethylcellulose, 2 parts of carbomer, 2 parts of trisodium citrate, and 0.01 part of mint essence , 0.01 p...

Embodiment 2

[0021] A preparation method of oral ulcer gargle described in embodiment 1: comprising the steps of dissolving maltodextrin, trisodium citrate, peppermint essence, sodium saccharin, and glycerin in purified water, and adding carboxymethyl cellulose Sodium, carbomer, and then stir until completely dissolved, and control the pH value at 3.5-5.5.

[0022] The specific preparation method is as follows:

[0023] Dissolve the ingredients of maltodextrin, carbomer, sodium carboxymethyl cellulose, trisodium citrate, mint flavor, sodium saccharin, glycerin, sodium chloride, potassium hydroxide in water, stir until completely dissolved or use heating , ultrasound and other auxiliary dissolution methods to promote dissolution.

[0024] Or change the order of adding samples: first dissolve maltodextrin, trisodium citrate, mint essence, sodium saccharin, glycerin, sodium chloride, and potassium hydroxide in water, and then add the amount of carbomer and carboxymethyl fiber Sodium sodium,...

Embodiment 3

[0027] Oral ulcer gargle clinical application of the present invention:

[0028] 1. A total of 92 cases of recurrent oral ulcer patients were observed in this embodiment, including 46 cases in the treatment group and 46 cases in the control group. There were 44 males and 48 females, aged 16 to 65 years, with an average (35.48±5.84) years old. There was no significant difference in gender, age and medical history between the two groups of patients, and they were comparable. Therefore, this clinical trial adopts a randomized parallel controlled trial design. The subjects were randomly divided into experimental and control groups.

[0029] 2. Inclusion criteria:

[0030] 1) Volunteer to participate in this clinical trial and sign the informed consent.

[0031] 2) Diagnosed with recurrent oral ulcers (recurrent oral ulcers are also known as recurrent aphthous ulcers, recurrent aphthous stomatitis, recurrent aphthous ulcers)---Diagnosis basis: "Clinical Disease Diagnosis Basis ...

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Abstract

The invention relates to the field of medicine preparation, particularly to dental ulcer gargle and a preparation method thereof. The dental ulcer gargle is prepared by mixing the following components: maltodextrin, sodium carboxymethylcellulose, Carbomer, trisodium citrate, saccharin sodium salt, sodium chloride, potassium hydroxide and purified water. The dental ulcer gargle has the benefits that the dental ulcer gargle does not have toxic and side effects on surface wounds of oral mucosa and is non-irritant. With secretion and neutralization of saliva, the dental ulcer gargle in an oral cavity is changed into hydrogel flooding the whole oral cavity, so that a protective membrane is formed on the surface of a dental ulcer, physically covering the wound and relieving the pain caused by the dental ulcer, oral inflammation and tiny wounds caused by dental hoops or false teeth; meanwhile, the hydrogel further has a certain effect of stopping bleeding.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a mouth ulcer gargle and a preparation method thereof. Background technique [0002] Oral ulcer is a kind of common frequently-occurring disease, has the common symptom of oral mucosa disease, and recurrent oral ulcer, aphthous ulcer are the most common oral ulcers, and the sickness rate in the crowd is about 20%. Oral ulcers can occur at any age. The proportion of women suffering from this disease is relatively high, and it can occur all year round. It is characterized by repeated attacks, burning pain, which affects the patient's normal diet, and can also cause various complications. Most patients can self-heal, but the duration of severe cases is longer, and because of its recurrent characteristics, it brings great misery to the patient. [0003] The etiology of oral ulcers is unknown, and the etiology of some patients is related to tension, trauma, smoking cessa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/36A61K47/32A61P1/02A61P7/04A61P29/00
CPCA61K9/006A61K9/08A61K47/32A61K47/36
Inventor 胡博志兰增金郑琦
Owner LANJIATANG BIOLOGICAL MEDICINE FUJIAN CO LTD
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