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Application of coenzyme Q10 in treatment of periodic paralysis disease

A periodic paralysis and coenzyme technology, applied in the field of medicine, can solve the problems of patients and families with heavy psychological burden, respiratory paralysis, recurrent attacks, etc.

Active Publication Date: 2016-10-12
XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, potassium chloride is often used orally or injected clinically, but the disease cannot be cured, resulting in recurrent attacks. In severe cases, it may also cause respiratory paralysis or arrhythmia, which brings a heavy psychological burden to patients and families.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Patient 1, male, 29 years old, with a medical history of 13 years. Thirteen years ago (16 years old), he began to experience several episodes of limb weakness accompanied by increased sweating, no muscle rigidity, no dyspnea, dysphagia and other discomforts. One and a half years ago, the patient's symptoms gradually aggravated, with frequent attacks, once a week, often in the morning or at noon, usually lasting 2-3 days, occasionally lasting 1 week, poor sleep, high carbohydrate diet or cold stimulation may cause induced seizures. The most severe attack was manifested as weakness of limbs when exposed to cold environment after eating, inability to move, normal breathing, no treatment, rested for about 7 days and improved.

[0035] During the attack, the serum potassium was normal, and there was no response to potassium and sodium supplementation. Interictal neurologic examination was normal. Routine laboratory tests including blood routine, urine routine, biochemistr...

Embodiment 2

[0038] Patient 2, male, 50 years old, with a medical history of 13 years. 13 years ago (37 years old) he had episodic generalized weakness in the exam. The seizures were frequent in the past 2 weeks, about 2 times a week. The cold environment can induce the seizures. The seizures mostly occur in the morning and evening, and occasionally in the afternoon. Usually, they can be relieved obviously within 1 hour, and the symptoms disappear in 2-3 days. After the seizure, the patient Conscious muscle pain.

[0039] During one attack, the patient's serum potassium was 2.8mmol / L, and the patient's weakness symptoms gradually improved after potassium supplementation. The patient's father and two brothers in the family had similar symptoms, but the symptoms were milder each time and the symptoms improved significantly after potassium supplementation. The patient's physical examination was normal between seizures. The thyroid function was normal, and no long-range exercise-induced tes...

Embodiment 3

[0042] In order to further verify the therapeutic effect of coenzyme Q10 on periodic paralysis, 19 patients with periodic paralysis were given coenzyme Q10 10 Oral treatment, 30mg each time, 3 times / day.

[0043] General clinical data: Among the 19 patients, there were 18 males and 1 female, aged 15-54 years, with an average age of 31.4 years. Attack situation: 6 cases had the first attack, 1 case had the second recurrence, and 12 cases had the third attack or more. The onset causes were fatigue in 6 cases, full meal in 2 cases, alcoholism in 1 case, cold exposure in 1 case, infection in 1 case, and 8 cases without obvious inducements. In addition, some cases had multiple predisposing factors. All cases had different degrees of episodic muscle weakness. The most serious muscle weakness was grade 0, and the lightest was grade 5. The characteristics of muscle weakness were that the proximal end was heavier than the distal end, and the upper limbs were heavier than the lower lim...

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Abstract

The invention relates to an application of a coenzyme Q10 in treatment of the periodic paralysis disease. Periodic paralysis is a disease with the characteristic of repeated outbreak of limb flaccid paralysis and most seriously affects male young adults; the disease cannot be cured once and for all through oral administration or injection of potassium chloride frequently applied in clinic at present, as a result, the disease is recurrent, respiratory paralysis or arrhythmia is probably caused when the condition is serious, and a patient and a family suffer from the heavy psychological burden. Long-term clinical practice and careful observation prove that the coenzyme Q10 can effectively treat periodic paralysis, and the disease is not recurrent after the patient takes the coenzyme Q10 for a period of time; with the application of the coenzyme Q10 in the treatment of periodic paralysis, the effect is good, safety and reliability are realized, the treatment cost is low, and the coenzyme Q10 has good clinical application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to coenzyme Q 10 The new use of, more specifically, coenzyme Q 10 Application in the treatment of periodic paralysis. Background technique [0002] coenzyme Q 10 (Coenzyme Q 10 , CoQ 10 ), the molecular formula is C 59 h 90 o 4 , The molecular weight is 863.37; , 27,31,35,39-decylmethyl-2,6,10,14,18,22,26,30,34,38-tetradecenyl)-5,6-dimethoxy-3 -Methyl-p-benzoquinone, 2,3-dimethoxy-5-methyl-6-(deca)poly-[2-methylbutenyl-2]benzoquinone, also known as ubiquinone, is A fat-soluble quinone compound widely exists in the cell membranes of animals, plants and microorganisms, and is an important electron acceptor in the electron transport chain of cell respiration. coenzyme Q 10 Physiological functions include scavenging free radicals and anti-oxidation functions, enhancing human immunity and anti-tumor, strengthening heart power, enhancing brain power, regulating blood lipids, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P21/04
CPCA61K31/122
Inventor 笪宇威
Owner XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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