Marker for detection of diabetes and application thereof

Abstract

The invention provides a marker for determining whether a subject has or will develop glucose impaired tolerance, or will develop type 2 diabetes. The marker includes one or more of glucose, beta-mannose monoglyceride and D-talose, and reaches diagnostic sensitivity was of 96.3%, and specificity of 0%.

Description

technical field [0001] The present invention relates to a diabetes marker, in particular, and further specifically relates to G01N33 / 68. Background technique [0002] The pathophysiological basis for altered glucose metabolism is multifactorial, such as lifestyle and genetic factors. In particular, in persons genetically susceptible to type 2 diabetes, obesity is considered to be the main cause of type 2 diabetes, and the rate of type 2 diabetes has increased significantly in parallel with obesity over the past 50 years. As of 2010, approximately 285 million people were living with the disease, compared to approximately 30 million in 1985. [0003] The development from normal glucose tolerance (healthy people) to type 2 diabetes includes the intermediate stages of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), known as prediabetes. [0004] Although factors such as age and body mass index (BMI) are associated with the development of prediabetes and ty...

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Problems solved by technology

[0004] Although factors such as age and body mass index (BMI) are associated with the development of prediabetes and type 2 diabetes, these factors are not sufficient to accurately predict the risk of developing from healthy individuals to IGT and/or from IGT to 2D. risk of type 2 diabetes, as the development and progression of diabetes

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