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Rehmannia root pill for improving eyesight and preparation method thereof

A Rehmannia Pill, Mingmu technology, applied in the directions of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of large dose, low bioavailability, affecting clinical application, etc. The effect of utilization

Inactive Publication Date: 2016-11-16
上海辰松新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In practice, the medicine is generally prepared by powdering the medicinal materials into the medicine, which has many impurities, large doses, and low bioavailability, which affects its clinical application.

Method used

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  • Rehmannia root pill for improving eyesight and preparation method thereof
  • Rehmannia root pill for improving eyesight and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Mingmu Dihuang Wan raw materials (parts by weight): 160 parts of Rehmannia glutinosa, 80 parts of Cornus officinalis (made), 60 parts of Moutan bark, 80 parts of Chinese yam, 60 parts of Poria cocos, 60 parts of Alisma, 60 parts of medlar, 60 parts of chrysanthemum, angelica 60 parts, 60 parts of Radix Paeoniae Alba, 60 parts of Tribulus terrestris, 80 parts of Cassia chinensis (calcined), 0.03 parts of auxiliary materials.

[0041] The preparation method of Mingmu Dihuang Wan comprises the following steps:

[0042] (1) Pulverize Moutan cortex into 60 mesh coarse powder, sieve, and carry out supercritical CO 2 Fluid extraction, the extraction temperature is 45°C, the extraction time is 2 hours, the extraction pressure is 30MPa, the flow rate of carbon dioxide is 15kg / h, the extraction liquid and medicinal residue (I) are obtained, and the extraction liquid is refrigerated at -1°C for 90 minutes before taking out , using 300 mesh filter cloth to filter to obtain paeonol...

Embodiment 2

[0049] It is basically the same as Example 1, except that the auxiliary material is obtained by uniformly mixing oleuropein and betulinic acid in a mass ratio of 1:1. The Mingmu Dihuang Wan of Example 2 was obtained.

Embodiment 3

[0051] It is basically the same as Example 1, except that the auxiliary material is obtained by uniformly mixing oleuropein and chlorogenic acid at a mass ratio of 1:1. The Mingmu Dihuang Wan of Example 3 was obtained.

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Abstract

The invention discloses a Mingmu Dihuang Pill and a preparation method thereof. The Mingmu Dihuang Pill comprises the following raw materials in parts by weight: 140-180 parts of rehmannia glutinosa, 60-100 parts of Cornus officinalis (manufactured), and Moutan bark 40‑80 parts, 60‑100 parts of yam, 40‑80 parts of poria cocos, 40‑80 parts of Alisma, 40‑80 parts of wolfberry, 40‑80 parts of chrysanthemum, 40‑80 parts of angelica, 40‑80 parts of white peony, 40-80 parts of Tribulus terrestris, 60-100 parts of Cassia terrestris (calcined). The Mingmu Dihuang Pill of the invention has the effects of nourishing the kidney, nourishing the liver and improving eyesight. It can be used to treat liver and kidney yin deficiency, astringent eyes, photophobia, blurred vision, wind and tears embolism. Its preparation process uses supercritical CO 2 The fluid extraction technology can fully extract the oil-soluble and water-soluble active ingredients in the medicinal materials, improve the bioavailability of the medicinal materials, and the added excipients ensure the stable quality of the drugs.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to Mingmu Dihuang Pills and a preparation method thereof. Background technique [0002] Mingmu Dihuang Wan is a variety recorded in the 2000 edition of the "Chinese Pharmacopoeia". It is composed of Liuwei Dihuang Wan, adding Jusizi, chrysanthemum, angelica, white peony root, Tribulus terrestris, and Shicaiming (calcined) on the basis of Liuwei Dihuang Wan. , that is, Qiju Dihuang Pills plus Angelica and White Peony to nourish blood, and then combined with Tribulus terrestris and Cassia chinensis to improve eyesight and relieve nebula, so its function is to nourish the kidney, nourish the liver and improve eyesight. Light, blurred vision, and tears in the wind can be used for all cataracts and eye diseases caused by liver and kidney yin deficiency, and it can also be taken for undiagnosed pupil-spirit diseases in the whole body. In addition, extern...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/20A61P27/02A61K35/618
CPCA61K36/804A61K9/2013A61K9/2018A61K35/618A61K36/076A61K36/185A61K36/232A61K36/287A61K36/40A61K36/65A61K36/71A61K36/815A61K36/884A61K36/8945A61K2236/331A61K2236/37A61K2236/39A61K2236/51
Inventor 刘世超
Owner 上海辰松新材料科技有限公司
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