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Scar-removing composition and dressing

A composition and scar removal technology, applied in the field of biomedicine, can solve problems such as skin damage

Inactive Publication Date: 2016-11-16
GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Scar removal can be achieved through drugs, laser or surgery. Surgical laser methods have certain risks. Most of the drug scar removal products on the market currently use some organic macromolecular chemical products containing benzene rings or add some hormones to enhance the scar removal effect. Scar effect, such as the Chinese patent with the publication number CN105055235A, which uses chemical substances such as simethicone, paraben, and triethanolamine, which inevitably has certain damage to the skin

Method used

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  • Scar-removing composition and dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] 1. Collection of Stem Cell Conditioned Medium

[0065] Take the umbilical cord mesenchymal stem cells of the P3 generation and culture them with DMEMF12+10% FBS. When the cells are in the exponential growth phase and the confluence reaches 80%, remove the culture supernatant, wash twice with PBS, and add 0.15mL / cm 2 After the phenol red-free 1640 was cultured for 72 hours, the conditioned medium was collected, and the collected conditioned medium was centrifuged at 300 g for 5 minutes. The supernatant was taken and passed through a 0.22 μm filter membrane.

[0066] 2.3D modeling

[0067] Use the built-in laser of the 3D printer to scan the surface of the patient's scar to obtain data such as the size, shape, thickness of the wound, and the thickness of the epidermis and dermis of the patient's normal skin. Edit to make it produce a continuous surface image; use Studio4.0 software to convert the image into a stereolithography (.STL) file and import it into Solid Works s...

Embodiment 2

[0093] 1. Collection of Stem Cell Conditioned Medium

[0094] Take the umbilical cord mesenchymal stem cells of the P3 generation and culture them with DMEMF12+10% FBS. When the cells are in the exponential growth phase and the confluence reaches 90%, remove the culture supernatant, wash twice with PBS, and add 0.1mL / cm 2 After the phenol red-free 1640 was cultured for 72 hours, the conditioned medium was collected, and the collected conditioned medium was centrifuged at 200 g for 5 minutes, and the supernatant was taken and passed through a 0.22 μm filter membrane to obtain the stem cell conditioned medium for future use.

[0095] 2.3D modeling

[0096] Use the built-in laser of the 3D printer to scan the surface of the patient's scar to obtain data such as the size, shape, thickness of the wound, and the thickness of the epidermis and dermis of the patient's normal skin. Edit to make it produce a continuous surface image; use Studio4.0 software to convert the image into a s...

Embodiment 3

[0105] 1. Collection of Stem Cell Conditioned Medium

[0106] Take the umbilical cord mesenchymal stem cells of the P3 generation and culture them with DMEMF12+10% FBS. When the cells are in the exponential growth phase and the confluence reaches 80%, remove the culture supernatant, wash twice with PBS, and add 0.2mL / cm 2 After the phenol red-free 1640 was cultured for 72 hours, the conditioned medium was collected, and the collected conditioned medium was centrifuged at 400 g for 5 minutes, and the supernatant was taken, passed through a 0.22 μm filter membrane, and the resulting medium was the stem cell conditioned medium for use.

[0107] 2.3D modeling

[0108] Use the built-in laser of the 3D printer to scan the surface of the patient's scar to obtain data such as the size, shape, thickness of the wound, and the thickness of the epidermis and dermis of the patient's normal skin. Edit to make it produce a continuous surface image; use Studio4.0 software to convert the imag...

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Abstract

The invention provides a scar-removing composition which comprises a mesenchymal stem cell culture solution, an epidermal growth factor, vitamin C and vitamin E, wherein the mass concentration of the epidermal growth factor is 10-50ng / mL; the mass concentration of the vitamin C is 5-50mg / mL; the mass concentration of the vitamin E is 5-50mg / m; the mesenchymal stem cell culture solution is prepared by culturing P1-P5 generations of mesenchymal stem cells through a mixture medium and a phenol red-free medium sequentially; and the mixture medium comprises a culture medium DMEM / F12 and fetal calf serum. The scar-removing composition disclosed by the invention adopts the mesenchymal stem cell culture solution, is easy to obtain, low in immunogenicity and harmless to the human body, and the mesenchymal stem cells secrete active materials into the culture solution in the culture process and are matched with the vitamin C, the vitamin E and the epidermal growth factor, so that scars can be effectively reduced, and the skin wound is repaired. The invention also provides a dressing.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a scar-removing composition and a dressing. Background technique [0002] The acne scars left by puberty leave an indelible "mark of youth". With the progress of modern society, love of beauty not only represents a kind of right, but also a kind of respect for self. How to dilute this unpleasant "imprint of youth" has become a topic of concern to many beauty lovers. [0003] Scar removal can be achieved through drugs, laser or surgery. Surgical laser methods have certain risks. Most of the drug scar removal products on the market currently use some organic macromolecular chemical products containing benzene rings or add some hormones to enhance the scar removal effect. Scar effect, such as the Chinese patent whose publication number is CN105055235A, has adopted chemical substances such as simethicone, paraben and triethanolamine, which inevitably has certain dama...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P17/02A61L15/32A61L15/28A61L15/20A61L15/44A61L15/42A61L15/40A61K35/28A61K31/375A61K31/355
CPCA61K31/355A61K31/375A61K35/28A61K38/1808A61L15/20A61L15/28A61L15/32A61L15/40A61L15/42A61L15/44A61L2300/412A61L2300/414A61L2300/428A61L2300/45C08L5/08C08L5/10
Inventor 陈海佳葛啸虎王一飞麦锦连王小燕
Owner GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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