Method for early screening of lung cancer by using vacuum ultraviolet photoionization mass spectrometer

Abstract

The invention relates to a method for early screening of lung cancer by using a vacuum ultraviolet photoionization mass spectrometer, and belongs to the field of efficient and rapid non-invasive cancer screening. According to the method, lung cancer characteristic marking VOCs gas in human exhaled gas can be detected and analyzed directly. The method comprises the following steps: firstly, collecting gas exhaled by a person to be detected with a disposable aluminum foil gas sampling bag; then, enabling the gas to enter a vacuum ultraviolet photoionization VOCs mass spectrometer; processing sampling signals with a GHz threshold discrimination ion signal processer; identifying 20 types of components of the lung cancer characteristic marking VOCs gas in a data image on a computer, so as to compare and calculate with a lung cancer early screening algorithm dendrogram, and carry out risk assessment and early screening to judge whether a person suffers from lung cancer. The method can be applied to the aspects of screening of high-risk population, early detection of lung cancer, prognosis monitoring and the like, and has great significance in reducing the lethality of lung cancer.

Description

Technical field [0001] The invention relates to a method for early screening of lung cancer. Specifically, a vacuum ultraviolet photoionization mass spectrometer is used to detect lung cancer characteristic VOCs marked gas in the exhaled gas of a test subject to screen early lung cancer. It is an efficient, fast and non-invasive method. screening method. Background technique [0002] Lung cancer is one of the most threatening malignant tumors to human health and life worldwide. In recent years, with the frequent occurrence of smog across the country, the incidence of lung cancer in my country has been on the rise. When lung cancer patients are diagnosed, they are often in the middle and advanced stages, and the cure rate is extremely low. At present, for the early monitoring of lung cancer, the classic detection methods are low-dose CT scanning and bronchoscopy, but these detection methods are expensive, inefficient, invasive or increase the radiation to the human body, an...

AI Technical Summary

Problems solved by technology

Domestic Shanghai Jiaotong University, Zhang Guangwen and others have developed a patent (CN 103018282A) that uses a microsensor array electronic nose system to screen early lung cancer. However, this device is easily restricted by conditions such as humidity and temperature. Accurate detection

However, there are no reports or patents at home and abroad on the use of vacuum ultraviolet photoionization VOCs mass spectrometry to screen VOCs markers in early lung cancer patients.

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