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A kind of anti-tumor sustained-release implant and preparation method thereof

A slow-release implant, anti-tumor technology, applied in the field of biomedicine, can solve the problems of low tissue affinity, short half-life, difficult to enter into cells, etc., and achieve the effect of reducing drug concentration, increasing drug concentration, and reducing adverse reactions

Active Publication Date: 2019-03-29
THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above problems, the present invention provides an anti-tumor implant, which can make the local environment into an alkaline environment by using magnesium metal to degrade in the body, and the alkaline environment has the characteristics of inhibiting the growth of tumors. The 10-hydroxycamptothecin implant is made by applying hydroxycamptothecin to degradable magnesium, the purpose of which is to overcome the extremely short half-life of hydroxycamptothecin in the body, the low affinity with tissues, and the difficulty of entering cells the puzzle

Method used

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  • A kind of anti-tumor sustained-release implant and preparation method thereof
  • A kind of anti-tumor sustained-release implant and preparation method thereof
  • A kind of anti-tumor sustained-release implant and preparation method thereof

Examples

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Embodiment 1

[0022] Under nitrogen protection, 0.2g 10-hydroxycamptothecin, 8.0g lactide-glycolide copolymer (lactide accounted for 50% by mole, weight average molecular weight is 110,000), 2.0g powdered metal Magnesium (average particle size: 74um) was co-melted and extruded at 180°C; the rod-shaped extrudate was cooled and then cut to obtain an anti-tumor implant with a diameter of 0.5mm and a length of 3.0mm.

Embodiment 2

[0024] Under nitrogen protection, 0.7g 10-hydroxycamptothecin, 7.0g polyglycolide (weight-average molecular weight is 10,000), 3.0g powdered magnesium metal (average particle diameter is 300um) are co-melted and extruded, extrusion temperature The temperature is 220°C; after the rod-shaped extrudate is cooled, it is cut to obtain an anti-tumor implant with a diameter of 0.7mm and a length of 2.5mm.

Embodiment 3

[0026] Under nitrogen protection, 0.45g 10-hydroxycamptothecin, 4.5g polylactide (weight average molecular weight 11,000), 4.5g polydioxanone (weight average molecular weight 13,000), 1.0g powdered metal Co-melt extrusion of magnesium (average particle size: 5um) at an extrusion temperature of 180°C; cut the rod-shaped extrudate after cooling to obtain an anti-tumor implant with a diameter of 1.0 mm and a length of 4.0 mm.

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Abstract

The present invention belongs to the field of biomedicine, and particularly relates to an antitumor slow-release implantation agent, which comprises 10-hydroxycamptothecin, a degradable polymer and metal magnesium, and is obtained by a solution spraying or hot-melting extrusion process. According to the present invention, after the implantation agent is subjected to the surgical implantation, the slow release of the10-hydroxycamptothecin can be achieved, and compared with the traditional administration mode, the administration mode of the present invention has the following characteristics that the drug systemic toxicity can be substantially reduced in the premise of the effective maintenance of the local drug concentration of the tumor; the metal magnesium in the implantation agent can react with water in the body environment to generate magnesium hydroxide, such that the environment around the tumor can be adjusted to achieve the alkaline state so as to inhibit the tumor cell growth; and the implantation agent can be used alone or can be combined with other treatment methods to provide the treatment or tumor recurrence prevention effect.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to an implant for treating solid tumors and a preparation method thereof. Background technique [0002] Malignant tumors have become one of the main causes of human death, seriously threatening human health and reducing the quality of life of patients. Hepatocellular carcinoma is one of the common malignant tumors that seriously threaten human health. The annual global incidence of liver cancer ranks first in the incidence of malignant tumors. The fifth place in cancer rate and the third place in death rate; although the comprehensive treatment based on surgery has made great progress in the past 20 years, and the overall treatment effect of liver cancer has been significantly improved, there are still surgical problems in the treatment of liver cancer. High recurrence rate, insensitivity to chemotherapy drugs, low long-term survival rate and other problems. [0003] Chemothe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/02A61K47/34A61K31/4745A61P35/00
CPCA61K9/0024A61K31/4745A61K47/02A61K47/34
Inventor 张佳林王连嵩肖克沈何伟杨柯程彬张国庆
Owner THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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