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Brucea javanica oil oral emulsion and preparation method thereof

A javanica javanica oil and emulsion technology, which is applied in the fields of emulsion delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of poor patient tolerance, product failure characteristics, uneven milk particles, etc., and achieve short curative effect , reasonable cost, less toxic and side effects

Inactive Publication Date: 2016-12-21
上海颂露医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the process is unstable, temperature, emulsification time and production equipment all affect the product quality, resulting in uneven emulsion particles: oil and water stratification, cracking, phase inversion, flocculation and corruption are prone to occur in the product storage and cannot be used ;Storage conditions need to be protected from light, and the temperature should be kept within the range of 6±2°C; the service life is only 1 year, and the actual use is greatly affected by the environment, and the product often fails or has unqualified properties within the validity period; Brucea javanica oil In the clinical use of intravenous milk injection, side effects such as phlebitis, vascular sclerosis, hemangioma, muscle and blood vessel irritation, and allergic reaction occur, and the patient's tolerance is poor

Method used

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  • Brucea javanica oil oral emulsion and preparation method thereof
  • Brucea javanica oil oral emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Brucea javanica oil oral emulsion raw materials: 100 parts of Brucea javanica oil, 12 parts of phospholipids, 0.3 parts of preservative.

[0026] The phospholipid is obtained by stirring and uniformly mixing soybean lecithin, hydrogenated phospholipid and cephalin in a mass ratio of 1:1:1.

[0027] The preservative is obtained by stirring and mixing uniformly aniselide, mentholactone and berganolide in a mass ratio of 1:1:1.

[0028] The preparation method of above-mentioned Brucea javanica oil oral emulsion, comprises the following steps:

[0029] The phospholipid is mixed with water evenly, and the water consumption is 10 times of the phospholipid weight, and is transferred to a high-speed tissue grinder (the model provided by Shanghai Chemical Science Experimental Equipment Co., Ltd. is the DS-1 high-speed tissue grinder), and the 8000 RPM, stir three times, each 3 minutes, then add javanica javanica oil, continue to stir at 8000 rpm for 9 minutes, then add water 70...

Embodiment 2

[0031] It is basically the same as in Example 1, except that the phospholipid is obtained by stirring and mixing soybean lecithin and hydrogenated phospholipid at a mass ratio of 1:1. Obtain the javanica javanica oil oral emulsion of embodiment 2.

Embodiment 3

[0033] It is basically the same as Example 1, except that the phospholipids are obtained by stirring and uniformly mixing hydrogenated phospholipids and cephalin at a mass ratio of 1:1. Obtain the javanica javanica oil oral emulsion of embodiment 3.

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PUM

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Abstract

The invention discloses a brucea javanica oil oral emulsion and a preparation method thereof, wherein the brucea javanica oil oral emulsion is prepared from the following raw materials in parts by weight: 80-120 parts of brucea javanica oil, and 10-20 parts of phospholipid. The brucea javanica oil oral emulsion has an anti-cancer effect, is used as an auxiliary treatment agent for lung cancer, brain metastasis of lung cancer, gastrointestinal tumors and liver cancer, and also has the characteristics of reasonable cost, small toxic and side effects, convenient taking, and short curative effect, can be used for batch production, has wide suitable people, and has extremely high application value.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a javanica javanica oil oral emulsion and a preparation method thereof. Background technique [0002] Brucea javanica oil is an oily component extracted from the fruit of Brucea javanica, and the main component of the oil is oleic acid, which is one of the anti-tumor active ingredients. It is clinically used as an adjuvant therapeutic agent for the treatment of lung cancer, brain metastases of lung cancer, digestive tract tumors and liver cancer, with good curative effect. The current clinical application of Brucea javanica oil preparations is mainly provided in liquid form, such as the oil-in-water type Brucea javanica oil emulsion made from the petroleum ether extract of Brucea javanica as a raw material and refined soybean lecithin as an emulsifier. But the intravenous emulsion injection and the oral emulsion of Brucea javanica oil all have m...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/107A61K47/24A61P35/00A61P35/04
CPCA61K36/185A61K9/0053A61K9/107A61K47/24
Inventor 陆敏佳
Owner 上海颂露医药科技有限公司
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