A kind of stevia phenolic extract and its application in anti-inflammatory products

A stevia phenol and extract technology, applied in the field of stevia phenol extract and its application in anti-inflammatory products, can solve environmental pollution, waste of resources and other problems, achieve broad development and application prospects, and reduce NO content , the effect of rich sources of raw materials

Active Publication Date: 2017-09-05
CHENGUANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Stevia phenols exist as impurities in the production process of steviol glycosides, which need to be removed in the subsequent process, which not only causes waste of resources, but also causes great pollution to the environment

Method used

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  • A kind of stevia phenolic extract and its application in anti-inflammatory products
  • A kind of stevia phenolic extract and its application in anti-inflammatory products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] This example provides an experiment on the anti-inflammatory effects of stevia extracts in vitro.

[0027] 1.1 Experimental materials

[0028] 1.1.1 Reagents and instruments

[0029] Stevia phenolic extract; lipopolysaccharide (LPS), American Sigma company; chlorogenic acid, Chengdu Munster Biotechnology Co., Ltd.; NO, CCK-8 kit, Biyuntian Institute of Biotechnology; mouse feed (carbohydrate Compound 64%, protein 21%, fat 4%, fiber 5%), Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd.; other reagents are domestic analytical pure; SIGMA 3K15 benchtop centrifuge, Beijing Wuzhou Oriental Technology Development Co., Ltd.; HH-4 digital display constant temperature water bath, Jiangsu Jintan Ronghua Instrument Manufacturing Co., Ltd.; Axiovert 200 inverted microscope, Zeiss, Germany; Galaxy S CO 2 Incubator, RS Biotech, UK.

[0030] 1.1.2 Animals

[0031] SPF Balb / c male mice (6-8 weeks old), Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd., license number: SC...

Embodiment 2

[0041] This example provides an in vivo anti-inflammatory effect experiment of steviol phenolic extracts.

[0042] 2.1 Experimental materials

[0043] 2.1.1 Reagents and instruments

[0044] Stevia phenolic extract; Carrageenan, Shanghai Jianglai Biotechnology Co., Ltd.; Dexamethasone, MYM Biotechnology Co., Ltd.; NO, CCK-8 kit, Biyuntian Institute of Biotechnology; Mouse feed (carbon water Compound 64%, protein 21%, fat 4%, fiber 5%), Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd.; other reagents are domestic analytical pure; HH-4 digital display constant temperature water bath, Jintan City, Jiangsu Province Ronghua Instrument Manufacturing Co., Ltd.; Axiovert 200 inverted microscope, Zeiss, Germany.

[0045] 2.1.2 Animals

[0046] SPF grade ICR male mice (18~22g), Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd., license number: SCXK (Beijing) 2012-0001. During the experiment, the animals were kept at a temperature of 21±2°C, a relative humidity of 40±5%, ...

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Abstract

The invention discloses a phenolic extract of stevia rebaudiana and application of the phenolic extract in anti-inflammatory products, and belongs to the technical field of plant extracts. Main components of the phenolic extract of stevia rebaudiana disclosed by the invention are chlorogenic acid and flavonoid compounds. The phenolic extract of stevia rebaudiana can significantly inhibit xylene-induced ear swelling and carrageenin-induced paw swelling, inhibit LPS-induced macrophage NO release, can decrease the content of inflammatory factor NO in serum, and has good anti-inflammatory activity; the phenolic extract of stevia rebaudiana provided by the invention has advantages of rich source of raw materials, easy industrialization, no toxic or side effect and the like, and has broad development and application prospects as anti-inflammatory products.

Description

Technical field [0001] The invention belongs to the technical field of plant extracts, and relates to a stevia phenolic extract and its application in anti-inflammatory products. Background technique [0002] Stevia rebaudiana is a perennial herb of the Compositae family. It is native to Paraguay and Brazil in South America. It is currently known as one of the sugar plants with higher sweetness. It has become the third natural sugar after sucrose and beet sugar. source. At present, China is the world's largest producer and supplier of steviol glycosides, accounting for more than 80% of the global total. In addition to steviol glycosides, stevia also contains flavonoids, chlorogenic acid and other ingredients, and these ingredients have important biological activities, such as antibacterial, lowering blood pressure, lowering blood lipids, etc., and have been drunk as sweet tea and medicinal tea in its birthplace More than one hundred years of history. [0003] The production of s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P29/00A23L33/105
CPCA23V2002/00A61K36/28A61K2236/331A61K2236/39A61K2236/53A61K2236/55A23V2200/30A23V2250/028A23V2250/2116A23V2250/2132A23V2300/10A23V2300/14A23V2300/34A23V2300/50
Inventor 徐美利赵磊杨香瑜安晓东李乾丽连运河王成涛
Owner CHENGUANG BIOTECH GRP CO LTD
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