Acute myeloid leukemia miRNA and transcription factor model and construction method and application thereof

A transcription factor, acute myeloid technology, applied in the field of disease research, can solve problems such as no obvious improvement in prognosis, failure to improve curative effect, and poor prognosis

Active Publication Date: 2016-12-21
徐勇 +1
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Problems solved by technology

The long-term survival rate of AML patients under 60 years old is 30% to 40%, and the long-term survival rate of patients over 60 years old is only 10%. The average survival period of untreated patients is only about 3 months, and the prognosis is poor.
However, for elderly AML patients, various methods inc

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  • Acute myeloid leukemia miRNA and transcription factor model and construction method and application thereof
  • Acute myeloid leukemia miRNA and transcription factor model and construction method and application thereof
  • Acute myeloid leukemia miRNA and transcription factor model and construction method and application thereof

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Embodiment Construction

[0048] The miRNA and transcription factor models of acute myeloid leukemia and their construction methods and applications will be further described in detail below mainly in conjunction with the accompanying drawings and specific examples.

[0049] 1. Research on the regulatory mechanism of microRNA (miRNA) and transcription factors in acute myeloid leukemia

[0050] Source of samples: Bone marrow samples (case group) of 15 patients with acute myeloid leukemia were obtained from Shenzhen People's Hospital from August 2012 to February 2014, including 9 males and 6 females, aged 18-77 years, The average age is 40.0 years old. All AML patients met the diagnostic criteria of the FAB international classification, and were all first-onset cases. None of them received chemotherapy or radiotherapy before sampling. The bone marrow samples of 10 cases of anemia or fever patients with normal bone marrow (healthy control group) were collected from inpatients in the Affiliated Hospital o...

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Abstract

The invention relates to an acute myeloid leukemia miRNA and transcription factor model and a construction method and application thereof. The construction method includes: acquiring differential expression miRNA and different expression transcription factors of marrow samples of acute myeloid leukemia patients and a healthy contrast group, constructing a miRNA-transcription factor regulatory network model to obtain core miRNA and core transcription factors, and the like. The constructed miRNA and transcription factor model can be used for construction of diagnosis probes, chips or reagents, equipment and the like to provide intermediate result information or reference information for diagnosis of the acute myeloid leukemia patients. By the acute myeloid leukemia miRNA and transcription factor model, microRNA mediated network regulation contents are enriched, and an action mechanism of a microRNA and transcription factor mediated regulation network in AML (acute myeloid leukemia) is revealed. Research results lay the foundation for development of anti-leukemia medicines or biological products, and high application value is achieved.

Description

technical field [0001] The invention relates to the field of disease research, in particular to a miRNA and transcription factor model of acute myeloid leukemia and its construction method and application. Background technique [0002] Acute myeloid leukemia (AML) is a type of clonal proliferative acute hematologic malignancy derived from myeloid hematopoietic stem / progenitor cells, and it occurs frequently in middle-aged and elderly people. Elderly patients over 65 years old account for about 54% of AML. Different from the local invasive growth of solid tumors, AML is easy to spread throughout the body, invading various organs and tissues and causing fatal infection and hemorrhage. . The long-term survival rate of AML patients under 60 years old is 30% to 40%, and the long-term survival rate of patients over 60 years old is only 10%. The average survival period of untreated patients is only about 3 months, and the prognosis is poor. . AML seriously endangers human healt...

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Application Information

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IPC IPC(8): G06F19/12
Inventor 徐勇戴勇林小聪
Owner 徐勇
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