Application of heat-clearing Chinese medicinal composition combined with antibiotics to preparation of medicine for inhibiting inflammatory factors

A composition and antibiotic technology, applied in the field of medicine, can solve problems such as no traditional Chinese medicine composition and antibiotics, and achieve good application effect and the effect of inhibiting inflammatory factors

Inactive Publication Date: 2017-01-04
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no relevant technical report on the combination of traditional C

Method used

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  • Application of heat-clearing Chinese medicinal composition combined with antibiotics to preparation of medicine for inhibiting inflammatory factors
  • Application of heat-clearing Chinese medicinal composition combined with antibiotics to preparation of medicine for inhibiting inflammatory factors
  • Application of heat-clearing Chinese medicinal composition combined with antibiotics to preparation of medicine for inhibiting inflammatory factors

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. Experimental strains: Staphylococcus aureus (ATCC25923), Escherichia coli (ATCC25922) were purchased from China National Culture Bank. Suspend the lyophilized powder of the tested strains in sterile M-H(B) medium and spread evenly on the surface of the sterile M-H(A) plate, incubate overnight at 35°C for revival, after 18 hours a lawn grows on the surface of the plate, select the ones with good growth Single bacterial mass, re-smear on the M-H(A) slant, incubate under the same conditions for 18h, seal, and store in refrigerator at 4°C; the day before the test, take the slant bacteria and smear it on the M-H(A) plate, incubate overnight at 35°C, ready to use . All operations are done on a clean bench.

[0020] 2. Bacteria solution preparation method

[0021] Method 1: (preparation of high-concentration bacterial solution)

[0022] Pick 3-4 single colonies in 40 ml of M-H(B) medium. The test bacteria were enriched and cultured overnight for 16 hours (37°C, shaken i...

Embodiment 2

[0093] Embodiment 2 Applied Research

[0094] 1. Research objects: 30 patients with pelvic inflammatory disease diagnosed due to menstrual disorders, irregular vaginal bleeding, lower abdominal pain or increased leucorrhea from June 2014 to February 2015, aged 35-52 years.

[0095] 2. All patients were routinely checked for blood routine, liver and kidney function before treatment, and the last plasma was taken for detection of LPS, TNF-α, and NO. LPS, TNF-α, NO significantly increased patients given the Chinese medicine composition of the present invention (with Qianjinba, Andrographis paniculata, Rosa Radix, Gonglaomu and Shuangmianzhen referring to the formula ratio and method of Zhuzhou Qianjin Pharmaceutical Fuke Qianjin Tablets to prepare the composition, decoction or tablet) and azithromycin (with reference to the prescribed dose of azithromycin), azithromycin is taken separately from the traditional Chinese medicine composition of the present invention, with a time dif...

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Abstract

The invention discloses application of a heat-clearing Chinese medicinal composition combined with antibiotics to preparation of a medicine for inhibiting inflammatory factors. The inflammatory factors comprise plasma LPS, plasma NO (nitric oxide) and/or plasma TNF-alpha; the antibiotics are azithromycin, the active ingredients of the Chinese medicinal composition comprise flemingia philippinensis, andrographis paniculata, fructus rosae laevigatae, Chinese mahonia stem and zanthoxylum dissitum. According to the invention, the azithromycin and the Chinese medicinal composition which comprises five Chinese medical herbs of the flemingia philippinensis, andrographis paniculata, fructus rosae laevigatae, Chinese mahonia stem and zanthoxylum dissitum are in combined application, thereby having a good application effect of inhibiting the inflammatory factors, in addition, a large number of experiments show that the Chinese medicinal composition and the azithromycin play a synergistic role to realize targeted therapies on infection and inflammation, so as to provide a strong technical support for the new-field combined application of the Chinese medicinal composition and azithromycin.

Description

technical field [0001] The invention relates to the technical field of medicine, and more specifically, relates to the application of a heat-clearing traditional Chinese medicine composition combined with antibiotics in the preparation of medicines for inhibiting inflammatory factors. [0002] technical background [0003] Studies have found that when infection and inflammation occur, plasma endotoxin, plasma nitric oxide, and plasma tumor necrosis factor are produced in large quantities in patients, and the levels are higher than normal. Tumor necrosis factor (TNF-α) is an important cytokine produced by activated monocyte-macrophages. In infectious diseases and inflammation, it can stimulate vascular endothelial cells to express adhesion molecules, stimulate monocyte-macrophages and other The cells secrete chemotactic cytokines, which cause white blood cells to gather at the inflammatory site and promote the inflammatory response. Excessive TNF-α over-reaction will produce a...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61P15/00A61P15/08A61P31/00A61P31/04A61P29/00A61K31/7052
CPCA61K36/48A61K31/7052A61K36/19A61K36/29A61K36/738A61K36/758A61K2300/00
Inventor 龚云李伏君李维刘逆夫张鹏
Owner ZHUZHOU QIANJIN PHARMA
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