Magnetic resonance image probe based on hyaluronic acid-peptide dendrimer-gadolinium conjugates and preparation method thereof

A technology of dendritic macromolecules and hyaluronic acid, which is applied in the field of medical imaging, can solve the problems of difficult synthesis of macromolecules and excretion of size from the body, and achieve the effects of regular structure, high relaxation efficiency and improved relaxation efficiency
CN106310296AActive Publication Date: 2017-01-11SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2017-01-11

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Abstract

The invention provides a magnetic resonance image probe based on hyaluronic acid-peptide dendrimer-gadolinium conjugates. The magnetic resonance image probe structurally comprises a plurality of fan-shaped peptide dendrimer and gadolinium conjugates connected onto a hyaluronic acid carbohydrate chain. Hyaluronic acid (HA) is selectively taken as a macromolecular skeleton chain segment, and an MRI contrast agent (Dendronized-HA-Gd) based on the hyaluronic acid-peptide dendrimer-gadolinium conjugates is constructed in combination with the advantages of HA and peptide dendrimer. The structural skeleton has a biodegradable capacity, and a degradable segment is constructed without introducing other sensitive bonds.
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Description

technical field

[0001] The invention belongs to the technical field of medical imaging, and relates to a polymer magnetic resonance imaging probe, in particular to a magnetic resonance imaging probe based on a hyaluronic acid-peptide dendrimer-gadolinium conjugate and a preparation method thereof. Background technique

[0002] In the clinical diagnosis of magnetic resonance imaging, it usually takes several minutes or tens of minutes to complete the entire operation, while the current commercial gadolinium-based contrast agent circulates in the body for only ten minutes. During the imaging process, signal may appear The embarrassing situation that the contrast agent has been metabolized and excreted before the collection is completed limits its application in some more complex imaging. Therefore, at present, a lot of research work is focused on linking small-molecule gadolinium-based contrast agents to macromolecular carriers, such as dendrimers, liposomes, and macromolecula...

Claims

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