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Traditional Chinese medicinal composition for treating heart-spleen deficiency type narcolepsy

A technology for narcolepsy and heart-spleen deficiency, which is applied in the field of traditional Chinese medicine, can solve the problems of sodium oxybate with multiple indications, gastrointestinal dysfunction, and obvious adverse reactions, and achieve clinical curative effect, small side effects, and patients good compliance

Inactive Publication Date: 2017-02-22
QINGDAO CHENDA BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional central nervous system stimulants are rarely used because of obvious adverse reactions
New central stimulants such as modafinil have good safety, but there are adverse reactions such as headache, nausea, anxiety, tension, dry mouth, and diarrhea; sodium oxybate has many indications and a wide range of applications, but it also has dizziness, Ataxia, weight loss, depression, gastrointestinal dysfunction and other adverse reactions
Antidepressants are commonly used clinical anti-cataplexy drugs, which have certain effects on sleep paralysis and hypnagogic hallucinations, but have more adverse reactions than other drugs

Method used

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  • Traditional Chinese medicinal composition for treating heart-spleen deficiency type narcolepsy
  • Traditional Chinese medicinal composition for treating heart-spleen deficiency type narcolepsy
  • Traditional Chinese medicinal composition for treating heart-spleen deficiency type narcolepsy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 capsule

[0041] Prescription: Acanthopanax 12 parts, longan meat 18 parts, tangerine peel 6 parts, polygala 15 parts, Caulis Spatholobus 15 parts, Codonopsis 12 parts, Albizia juniper skin 10 parts, vine vine 12 parts, rush grass 5 parts, Poria cocos 14 parts, 6 parts of roasted licorice.

[0042] Preparation method: Take Spatholobus Spatholobus, Albizia Julibrissin, Gingeria Vertigo, and rushes and crush them into particles with an average particle size of 40 μm, add 7 times the amount of 65% ethanol aqueous solution, and use ultrasonic extraction. After ultrasonic extraction is completed, take the filtrate and reduce pressure. Concentrate and dry to obtain extract A, and set aside, wherein the extraction conditions include: ultrasonic power of 130-160W, extraction temperature of 30-50°C, and extraction time of 20-30min;

[0043] Add Acanthopanax, longan meat, tangerine peel, polygala, Codonopsis pilosula, Poria cocos, and Zhilicorice to decoct twice. Th...

Embodiment 2

[0044] Embodiment 2 capsules

[0045] Prescription: Acanthopanax 10 parts, longan meat 20 parts, tangerine peel 8 parts, polygala 15 parts, Caulis Spatholobus 10 parts, Codonopsis 12 parts, Albizia Julibrissin skin 8 parts, 8 parts of Nocturnal vine, rush grass 5 parts, Poria cocos 12 parts, 5 parts of roasted licorice.

[0046] Preparation method: Take Spatholobus Spatholobus, Albizia Julibrissin, Cauliflower, and rushes and grind them into particles with an average particle size of 30 μm, add 7 times the amount of 68% ethanol aqueous solution, and use ultrasonic extraction. After ultrasonic extraction is completed, take the filtrate and reduce pressure. Concentrate and dry to obtain extract A, and set aside, wherein the extraction conditions include: ultrasonic power of 130-160W, extraction temperature of 30-50°C, and extraction time of 20-30min;

[0047] Add Acanthopanax, longan meat, tangerine peel, polygala, Codonopsis pilosula, Poria cocos, and Zhilicorice to decoct twi...

Embodiment 3

[0048] Embodiment 3 capsules

[0049] Prescription: Acanthopanax 12 parts, longan meat 15 parts, tangerine peel 5 parts, polygala 12 parts, Caulis Spatholobus 12 parts, Codonopsis 15 parts, acacia skin 10 parts, vine 10 parts, rush grass 4 parts, Poria cocos 14 parts, Zhi Licorice 4 parts.

[0050] Preparation method: Take Spatholobus Spatholobus, Albizia Julibrissin, Gingeria Vertigo, and rushes and grind them into particles with an average particle size of 50 μm, add 9 times the amount of 60% ethanol aqueous solution, and use ultrasonic extraction. After ultrasonic extraction is completed, take the filtrate and depressurize Concentrate and dry to obtain extract A, and set aside, wherein the extraction conditions include: ultrasonic power of 130-160W, extraction temperature of 30-50°C, and extraction time of 20-30min;

[0051] Add Acanthopanax, longan meat, tangerine peel, polygala, Codonopsis pilosula, Poria cocos, and Zhilicorice to decoct twice. The first decoction is 1.5...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicinal composition for treating heart-spleen deficiency type narcolepsy and a preparation method thereof. The traditional Chinese medicinal composition is prepared through elaborate compounding of medicinal raw materials including acanthopanax roots, longan aril, dried tangerine or orange peels, polygala tenuifolia, caulis spatholobi, codonopsis pilosula, cortex albiziae, tuber fleeceflower stems, rush, poria cocos and honey-fried licorice roots. The traditional Chinese medicinal composition has the advantages that the effect of tonifying heart-spleen, nourishing blood, tonifying qi, removing dampness and purging heat is achieved through compatibility of the herbs, yang-qi circulation is promoted, and circulation of yin-qi and yang-qi is enabled to start and stop according to day and night rules; for the heart-spleen deficiency type narcolepsy, the traditional Chinese medicinal composition makes up for deficiencies, removes excesses and regulates deficiency and excess so as to promote qi circulation and eliminate evil; pertinency is high, and the effect is remarkable.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating narcolepsy of heart-spleen deficiency type and a preparation method thereof. Background technique [0002] Narcolepsy is a chronic central nervous system dysfunction disease, the main clinical features are irresistible excessive daytime sleepiness, nighttime sleep disturbance and pathological rapid eye movement sleep (REM) symptoms (triggered by intense emotion) episodic shattering, sleep paralysis, and hypnic hallucinations). The etiology of narcolepsy is unknown, and the prevalence rate is about 0.03%-0.16%. There are slight differences in reports from different countries, and there is no significant difference in the incidence rate between men and women. Narcolepsy often accompanies the whole life, seriously affects the quality of life of patients, and may even lead to accidents and endanger life. For example, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P25/20
CPCA61K9/0053A61K9/08A61K36/076A61K36/254A61K36/344A61K36/48A61K36/484A61K36/486A61K36/69A61K36/704A61K36/752A61K36/77A61K36/88A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K2300/00
Inventor 李国玉
Owner QINGDAO CHENDA BIOLOGICAL SCI & TECH
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