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Pharmaceutical composition for treating liver and gall excess heat type narcolepsy

A technology of narcolepsy and composition, which is applied in the field of traditional Chinese medicine, can solve the problems of sodium oxybate, such as multiple indications, gastrointestinal dysfunction, and obvious adverse reactions, and achieve definite clinical curative effect, small side effects, and patient compliance Good results

Inactive Publication Date: 2016-08-17
邱发龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional central nervous system stimulants are rarely used because of obvious adverse reactions
New central stimulants such as modafinil have good safety, but there are adverse reactions such as headache, nausea, anxiety, tension, dry mouth, and diarrhea; sodium oxybate has many indications and a wide range of applications, but it also has dizziness, Ataxia, weight loss, depression, gastrointestinal dysfunction and other adverse reactions
Antidepressants are commonly used clinical anti-cataplexy drugs, which have certain effects on sleep paralysis and hypnagogic hallucinations, but have more adverse reactions than other drugs

Method used

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  • Pharmaceutical composition for treating liver and gall excess heat type narcolepsy
  • Pharmaceutical composition for treating liver and gall excess heat type narcolepsy
  • Pharmaceutical composition for treating liver and gall excess heat type narcolepsy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 capsule

[0036] Prescription: 10 parts of gentian, 5 parts of coptis, 9 parts of citron, 12 parts of rose, 3.0 parts of woody fragrance, 8 parts of passepartout, 15 parts of medlar, 15 parts of jujube seed, 10 parts of scull, 12 servings of corn silk.

[0037] Preparation method: take citron, rose, and woody incense and grind them into particles with an average particle size of 10-60 μm, add 5-10 times the amount of 70% ethanol aqueous solution, and use ultrasonic extraction. After ultrasonic extraction is completed, take the filtrate and depressurize Concentrate into a thick paste to obtain extract A, and set aside, wherein the extraction conditions include: ultrasonic power of 130-160W, extraction temperature of 30-50°C, and extraction time of 10-50min;

[0038] Add water to decoct gentian grass, berberine, passepartout, wolfberry leaves, jujube kernels, sculls, and corn silk twice. The first decoction lasts for 1.5-2.0 hours, and the amount of water ad...

Embodiment 2

[0039] Embodiment 2 capsules

[0040] Prescription: 8 parts of gentian, 5 parts of berberine, 8 parts of citron, 12 parts of rose, 3.5 parts of woody fragrance, 8 parts of passepartout, 12 parts of medlar, 10 parts of jujube seed, 10 parts of scull, 12 servings of corn silk.

[0041] Preparation method: carry out with reference to the operation of Example 1.

Embodiment 3

[0042] Embodiment 3 capsules

[0043] Prescription: 10 parts of gentian, 5 parts of coptis, 12 parts of citron, 10 parts of rose, 3.5 parts of woody fragrance, 5 parts of passepartout, 12 parts of medlar, 10 parts of jujube seed, 12 parts of scull, 10 servings of corn silk.

[0044] Preparation method: carry out with reference to the operation of Example 1.

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Abstract

The invention belongs to the field of traditional Chinese medicine and relates to a pharmaceutical composition for treating liver and gall excess heat type narcolepsy and a preparation method thereof. The pharmaceutical composition is prepared by elaborately developing medicinal raw materials including gentian, rhizoma coptidis, fructus citri, flos rosae rugosae, radix aucklandiae, fructus liquidambaris, folium ilicis cornutae, semen ziziphi spinosae, fruits of thatch screwpine and corn stigma according to a certain ratio of parts by weight. All the medicinal materials interact and are combined, the effects of soothing the liver to regulate qi, and dissipating phlegm for resuscitation are achieved, heat is cleared, humidification is realized, phlegm is removed, yin and yang are in harmony, the pharmaceutical composition is applied according to syndrome differentiation of liver and gall excess heat type narcolepsy, and the effect is remarkable.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical composition for treating narcolepsy of liver and gallbladder excess heat type and a preparation method thereof. Background technique [0002] Narcolepsy is a chronic central nervous system dysfunction disease, the main clinical features are irresistible excessive daytime sleepiness, nighttime sleep disturbance and pathological rapid eye movement sleep (REM) symptoms (triggered by intense emotion) episodic shattering, sleep paralysis, and hypnic hallucinations). The etiology of narcolepsy is unknown, and the prevalence rate is about 0.03%-0.16%. There are slight differences in reports from different countries, and there is no significant difference in the incidence rate between men and women. Narcolepsy often accompanies the whole life, seriously affects the quality of life of patients, and may even lead to accidents and endanger life. For example, chil...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P25/00A61P25/20
CPCA61K36/185A61K36/285A61K36/515A61K36/718A61K36/725A61K36/738A61K36/752A61K36/88A61K36/899A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 邱发龙
Owner 邱发龙
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