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A kind of pharmaceutical composition for treating Hashimoto's thyroiditis and preparation method thereof

A technology of thyroiditis and composition, applied in the field of pharmaceutical composition for the treatment of Hashimoto's thyroiditis, can solve the problems of lack of prescription preparations, inconvenient use, restriction of iodine intake, etc., achieve unique composition and reduce inflammatory infiltration , to reduce the effect of damage

Active Publication Date: 2019-06-18
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Limit iodine intake
Its shortcoming is that the use is mainly based on decoction, which is inconvenient to use, lacks prescription preparations, and urgently needs to be researched and developed.

Method used

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  • A kind of pharmaceutical composition for treating Hashimoto's thyroiditis and preparation method thereof
  • A kind of pharmaceutical composition for treating Hashimoto's thyroiditis and preparation method thereof
  • A kind of pharmaceutical composition for treating Hashimoto's thyroiditis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0203] Weigh raw materials according to the following proportions: 10 parts of Bupleurum bupleurum, 20 parts of turmeric, 30 parts of Prunella vulgaris, 10 parts of Chuanshanlong, 15 parts of Fritillaria, 10 parts of Scrophulariaceae, 6 parts of Shanzi mushroom, 30 parts of Astragalus, 15 parts of black plum share.

[0204] Preparation method: Take the medicinal materials of ebony, Fritillaria, Scrophulariaceae, Radix Astragali, and Sagittarius in the prescription, add 10 times the amount of water, decoct 3 times for 2 hours each time, combine the decoctions, and concentrate to a relative density of 1.05-1.10 ( 50 DEG C), add ethanol to make the ethanol concentration reach 70%, filter, reclaim the filtrate, and dry under reduced pressure to obtain the water extract extract; get the northern Bupleurum, curcuma, Prunella vulgaris, and Chuanshanlong medicinal materials in the prescription, add 6 Double the amount of 70% ethanol solution, reflux and extract 3 times, each time for ...

Embodiment 2

[0207] The raw materials were weighed according to the following proportions: Bupleurum 330g, Curcuma 330g, Prunella vulgaris 990g, Wumei 495g, Fritillaria 495g, Scrophulariaceae 330g, Chuanshanlong 330g, Sagittarius 198g, Astragalus 990g.

[0208] Preparation method: Take the medicinal materials of ebony, Fritillaria, Scrophulariaceae, Radix Astragali, and Sagittarius in the prescription, add 10 times the amount of water, decoct 3 times for 2 hours each time, combine the decoctions, and concentrate to a relative density of 1.05-1.10 ( 50 DEG C), add ethanol to make the ethanol concentration reach 70%, filter, reclaim the filtrate, and dry under reduced pressure to obtain the water extract extract; get the northern Bupleurum, curcuma, Prunella vulgaris, and Chuanshanlong medicinal materials in the prescription, add 6 Double the amount of 70% ethanol solution, reflux and extract 3 times, each time for 1h, combine the alcohol extracts, recover, and dry under reduced pressure to o...

Embodiment 3

[0211] Weigh raw materials according to the following proportions: 10 parts of Bupleurum bupleurum, 20 parts of turmeric, 30 parts of Prunella vulgaris, 10 parts of Chuanshanlong, 15 parts of Fritillaria, 10 parts of Scrophulariaceae, 6 parts of Shanzi mushroom, 30 parts of Astragalus, 15 parts of black plum share.

[0212] Preparation method: take the medicinal materials Bupleurum bupleuri, turmeric, Prunella vulgaris, Chuanshanlong, Fritillaria, Scrophulariae, Sanzi mushroom, Astragalus, and black plum, add 8 to 12 times the amount of water, decoct 2 to 3 times, combine the decoction, Precipitate with 50-80% alcohol, filter, concentrate the filtrate to a relative density of 1.15-1.20 at 60°C, granulate, dry, and add dressing to prepare a finished dosage form.

[0213] Wherein, the finished dosage forms are granules, capsules, tablets, and pills made of pharmaceutically acceptable carriers or excipients.

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Abstract

The invention relates to a pharmaceutical composition for treating Hashimoto's thyroiditis and a preparation method thereof. The pharmaceutical composition is composed of bupleurum, radix curcumae, prunella vulgaris, rhizoma Dioscoreae Nipponicae, thunberg fritillary bulb, radix scrophulariae, edible tulip, astragalus, dark plum and other components, and can be made into granules, capsules, tablets or pills by the conventional pharmaceutical processes. The pharmaceutical composition has the effects of soothing liver-qi stagnation, reducing phlegm, removing stasis, and softening hardness to dissipate stagnation, and applies to patients with Hashimoto's thyroiditis and thyroid nodules. Clinical studies have shown that the pharmaceutical composition can significantly improve the symptoms of Hashimoto's thyroiditis, reduce the thyroid volume and isthmus thickness, and reduce the level of TgAb and TPOAb, and the total effective rate is 97.22%. In addition, for patients with thyroid nodules, nodules can be significantly reduced or even disappeare, no significant adverse reactions are presented in the course of treatment. Experimental studies have shown that the pharmaceutical composition reduces the level of TgAb and TPOAb, and reduces inflammatory infiltration and thyroid follicular damage.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition for treating Hashimoto's thyroiditis and a preparation method thereof. 2. Background technology [0002] Hashimoto's thyroiditis (Hashimoto's thyroiditis, HT), also known as chronic lymphatic thyroiditis, is one of the important causes of hypothyroidism. The main manifestations of the disease are elevated TgAb and TPOAb and inflammatory infiltration in the thyroid gland. In the early clinical stage, it may be accompanied by hyperthyroidism or normal thyroid function, and in the later stage, it may be manifested as hypothyroidism. There are also those with nodules and thyroid cancer. Generally, the diagnosis is aided by antibody examination and B-ultrasound examination, and the diagnosis is confirmed by fine-needle aspiration cytology. The global incidence of HT is 0.3-1.5 cases per 1000 people, and the incidence rate of women is 10-15 times that of men. It can occur at any age, especially in wo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/16A61K9/20A61K9/48A61K9/70A61P5/14
CPCA61K9/1652A61K9/2004A61K9/4808A61K9/70A61K36/233A61K36/481A61K36/536A61K36/736A61K36/808A61K36/8945A61K36/8966A61K36/898A61K36/9066A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 刘铜华
Owner BEIJING UNIV OF CHINESE MEDICINE
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