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Veterinary pharmaceutical composition and use thereof

A composition and veterinary drug technology, applied in the direction of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of cost-intensive, expensive preparation, etc.

Inactive Publication Date: 2017-02-22
VEYX PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually, such liposomes are extremely expensive to prepare
Furthermore, the use of biodegradable polymers is relatively cost-intensive

Method used

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  • Veterinary pharmaceutical composition and use thereof
  • Veterinary pharmaceutical composition and use thereof
  • Veterinary pharmaceutical composition and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0088] figure 1 Four in vitro release kinetics of gonadorelin [6-D-phenylalanine] acetate in different oil-containing suspensions are shown. Here, the release is delayed in each case relative to a matrix which does not delay the release.

[0089] In addition to gonadorelin [6-D-phenylalanine] acetate, the following materials were used for the study, figure 1 Show its result:

[0090]

[0091] The following formulations were formulated to determine release kinetics:

[0092]

[0093]

[0094] To prepare the respective suspensions, castor oil was mixed with Miglyol in a ratio of 9:1 at 60 °C under nitrogen. Next, the mixture was cooled to 25°C and lyophilized Gonadorelin [6-D-phenylalanine] acetate was incorporated. Homogenization was performed at 2000 rpm for five minutes using an Ultra-Turrax tube disperser. Next, dilute the solution with castor oil and / or Miglyol in order to achieve the concentrations and viscosities of gonadorelin [6-D-phenylalanine] acetate pr...

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Abstract

The invention concerns a veterinary pharmaceutical composition comprising at least one active veterinary pharmaceutical substance selected from gonadorelin and gonadorelin analogues and salts of gonadorelin and gonadorelin analogues. A feature of the invention is that the composition comprises a liposome-free matrix which delays release of the active veterinary pharmaceutical substance from the composition and which comprises a base material selected from the group consisting of natural and synthetic triglycerides, vegetable oils, diacylpropanediols, diacylbutanediols and mixtures of these substances, the veterinary pharmaceutical composition comprising no biodegradable polymer.

Description

technical field [0001] The present invention relates to a pharmaceutical composition according to the preamble of claim 1 and to the use of said pharmaceutical combination according to the preamble of claim 17 . Background technique [0002] In order to synchronize the sexual cycle of gilts, cycle arrest has long been performed with the hormone allylregest. [0003] This cycle synchronization in fertile gilts (sexually mature sows prior to first litter) is used for the following purposes: to synchronize estrus (estrus) and / or ovulation, to enable artificial Fertilization to give up work-consuming estrus control to a defined point in time. The decisive advantages for the animal and the animal breeder arise from this synchronization of cycles, namely, the additional multi-day search for animals in heat, simplified sperm supply, simultaneous appearance of sows in the gestation phase and concentration of animal husbandry efforts On days and hours that can be scheduled. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/09A61P15/08A61K9/107
CPCA61K38/09A61K9/107A61K9/0019A61K9/0024A61K47/14A61K9/10A61K47/44A61P15/08A61K9/0002A61K38/24
Inventor 沃尔夫冈·扎伦巴约翰内斯·考福尔德沃尔夫冈·弗里斯克斯廷·霍夫曼约尔丹卡·约尔丹诺娃
Owner VEYX PHARMA