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Method for screening cancer prevention agent or anticancer agent using morphological characteristics of luterial

A technology for anticancer agents and preventive agents, which can be used in the screening of compounds, scientific instruments, electrochemical variables of materials, etc., and can solve the problems of low efficiency of anticancer agents and long time of anticancer agents

Inactive Publication Date: 2017-04-19
崔元哲 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method has the disadvantage of inefficiency for screening a large number of anticancer agents because the screening of dose- and injection-frequency-dependent effects of anticancer agents takes a long time to be performed.

Method used

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  • Method for screening cancer prevention agent or anticancer agent using morphological characteristics of luterial
  • Method for screening cancer prevention agent or anticancer agent using morphological characteristics of luterial
  • Method for screening cancer prevention agent or anticancer agent using morphological characteristics of luterial

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0186] Example 1: Separation of Luterial

[0187]As shown in Table 5 below, Luterial was isolated from the blood of the following patients: (1) lung cancer patients, (2) pancreatic cancer patients, (3) colon cancer patients, (4) liver cancer patients, (5) prostate cancer patients, ( 6) Breast cancer patients, (7) Thyroid papillary carcinoma patients, (8) Kidney cancer patients, (9) Leukemia patients, (10) Patients with advanced cancer (stomach cancer, colorectal cancer, gallbladder cancer) and (11) Patients with stage 4 metastatic cancer (lung, prostate, breast) were identified. Blood is collected from patients confirmed to have cancer and then centrifuged to settle material in the blood. Allow the centrifuged blood to sit for 5-10 minutes, then collect the supernatant by pipetting. Subsequently, 5 μl of CD39 antibody-conjugated ferromagnetic nanoparticles or CD73 antibody-conjugated ferromagnetic nanoparticles were added to 100-200 μl of blood and incubated for 30 min, af...

Embodiment

[0190] Example: Preparation of Candidates

[0191] 100 g of the following medicinal plants were cut to fit a 2-3 liter (20- to 30-fold by volume) size container and placed in the container: sumac, forsythia, poria cocos, angelica root and kiwi fruit. Then 500-800 g (equivalent to 5-8 times the plant weight, preferably 600 g of 6 times the plant weight) of distilled water was added to the container, followed by shaking at 80° C. for about 8 hours, thereby obtaining a hot water extract. CD39 antibody-conjugated ferromagnetic nanoparticles or CD73 antibody-conjugated ferromagnetic nanoparticles were added to 100-200 μl of hot water extract and incubated for 30 minutes. Next, the mixture was maintained in a magnetic separator for 1-2 minutes to collect Luterion-bound magnetic nanoparticles, and the supernatant was discarded, followed by washing. Next, 0.033 wt % BSA (Bovine Serum Albumin) / PBS buffer was added to the Luterion-bound magnetic nanoparticles, followed by incubation ...

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Abstract

The present invention relates to a method for screening a cancer prevention agent or an anticancer agent, the method comprising the steps of: (a) isolating mutant luterial or normal luterial from body fluids previously eliminated from a patient or a normal person; (b) treating the isolated mutant luterial with candidates for an anticancer agent or cancer prevention agent; and (c) selecting, as an anticancer agent, a candidate which reduces the size of the mutant luterial, changes the shape of the mutant luterial, or increases mobility of the mutant luterial compared with a control group before the treatment with the candidates, or selecting, as a cancer prevention agent, a candidate which suppresses the size increase of luterial, minimizes the morphological change of luterial, or maintains mobility of luterial compared with a control group before the treatment with the candidates.

Description

technical field [0001] The present invention relates to methods of screening anticancer agents based on the morphological characteristics of a Luterial, and more particularly, to methods for screening anticancer agents or cancer agents based on comparisons to control mutant Luterials or Luterials prior to treatment with anticancer agents or cancer prevention candidates. A method for screening and selecting anticancer agents or cancer prevention candidates by preventing the ability of candidates to induce changes in size, shape or mobility of mutant Luterials or to inhibit changes in size, shape or mobility of Luterials. Background technique [0002] Cancer is one of the major diseases threatening human health and is a disease in which cells proliferate in an unlimited and uncontrollable manner through a series of mutational processes. Various biochemical mechanisms associated with cancer have been identified and improved methods for cancer detection and mass screening have b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/53G01N33/48
CPCG01N33/5011G01N33/5026G01N33/5044G01N33/5076G01N33/5097G01N33/5432G01N2500/10G01N33/48G01N33/574G01N27/26
Inventor 崔元哲权宁娥崔硕训崔彰训
Owner 崔元哲
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