Application of Zukamu granules to preparation of drugs for resisting coxsakievirus and rhinovirus infection

A technology of zuka wood and wood granules, applied in the field of zuka wood granules and its application in the preparation of anti-coxsackie virus and rhinovirus infection drugs, can solve the problem of no specific antiviral drugs and achieve good therapeutic effect , Strict structure, reduce the effect of damage

Inactive Publication Date: 2017-05-10
新疆维吾尔药业有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are no specific antiviral drugs for disease caused by coxsackievirus and rhinovirus infection

Method used

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  • Application of Zukamu granules to preparation of drugs for resisting coxsakievirus and rhinovirus infection
  • Application of Zukamu granules to preparation of drugs for resisting coxsakievirus and rhinovirus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Primary anti-Coxsackie virus type B3 (CVB3) activity

[0042] 1. Principle: Vero (African green monkey kidney) cells are used as virus hosts to determine the extent to which samples inhibit Coxsackie virus B3 from causing Vero cell lesions.

[0043] 2 Materials and methods

[0044] 2.1 Virus strain: CVB3 (Nancy strain), provided by ATCC.

[0045] 2.2 Sample treatment: Before the sample is used, the DMSO is made into the mother solution, and the culture solution is used to dilute to a certain concentration during the test, and then diluted 3 times, a total of 8 dilutions.

[0046] 2.3 Blank control drug: Xinjiang Uygur Pharmaceutical Co., Ltd.

[0047] 2.4 Test method: 96-well culture plate of Vero cells, infected with Coxsackie virus B3 type 10 after 24 hours -5 , adsorb for 2 hours, discard the virus solution, add the maintenance solution containing samples of different dilutions and blank control drugs, and set up cell control wells and virus control wells at the s...

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PUM

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Abstract

The invention discloses Zukamu granules. The Zukamu granules are prepared from rhizome kaempferiae, nymphaea tetragona, mint, jujubes, chamomile, cordia dichotoma fruits, liquorice, hollyhock seeds, rheum officinale and pericarpium papaveris. The Zukamu granules are used for resisting coxsakievirus and/or rhinovirus infection. The Zukamu granules can effectively inhibit activity of coxsakievirus and rhinovirus, regulate abnormal constitution, clear heat, promote sweating and open orifices and is used for treating cold coughs, fever adiaphoresis, sore throat and nasal congestion.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to Zukamu granules and their application in the preparation of anti-coxsackie virus and rhinovirus infection drugs. Background technique [0002] Coxsackievirus (Coxsakievirus) belongs to the enterovirus genus of the picornacleaceae family. According to its pathogenicity to suckling mice, it is divided into two groups, A and B. Group A can cause extensive myocarditis and necrosis in suckling mice, and group B can cause Focal myocarditis. Coxsackie virus infection in humans can cause a wide range of diseases, ranging from mild respiratory infection symptoms to more severe myocarditis, pericarditis and some diseases of the nervous system. In particular, Coxsackie virus group B is the main cause of viral myocarditis, chronic dilated cardiomyopathy, primary myocardial disease, chronic pancreatitis, meningitis, pleuritic pain, and intercostal pain. [0003] Human rhinoviruse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/906A61P31/14
CPCA61K36/906A61K36/185A61K36/28A61K36/30A61K36/484A61K36/534A61K36/62A61K36/66A61K36/708A61K36/725A61K2300/00
Inventor 尹强尹海龙周琴穆丹丹黄璐努尔拉江·帕合尔丁田芳刘腊才宋菲刘秋云王丽敏刘哲
Owner 新疆维吾尔药业有限责任公司
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