36 results about "Rhinovirus infection" patented technology

The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a host, including animals, and especially humans, using a (2′R)-2′-deoxy-2′-fluoro-2′-C-methyl nucleosides, or a pharmaceutically acceptable salt or prodrug thereof.

The present invention provides the use of carrageenan or mixtures thereof for the manufacture of an antiviral pharmaceutical composition for the treatment of rhinovirus infections.

The invention provides a method for rapidly detecting HRV typing and EV by single-tube multiplex-RT-PCR. The method comprises the following steps: a) collecting a sample; b) extracting nucleic acid from the sample; c) adding the extracted nucleic acid to a premixed RT-PCR reagent; d) running an RT-PCR amplification program; and e) performing fragment analysis on the obtained RT-PCR amplification product, wherein the premixed RT-PCR reagent contains a primer specifically for HRV typing and a primer specifically for EV. The method has the advantages of simplicity in operation, short time and high flux, so a result can be obtained in 4 h at the soonest, and the method is suitable for clinic detection and scientific researches. The HRV virus typing result detected by the method can be used forguiding clinicians to medicate, and also can be used for the pathological study of rhinovirus infection.

The alpha-interferon has been used mainly in treating chronic viral infection. The present invention uses coronavirus or rhinovirus infected human cervical cancer cell as estimation model in observing the inhibition effect of alpha-interferon on common virus causing respiratory system infection. The results show that alpha-interferon may be used in preventing and treating coronavirus and rhinovirus caused diseases, including SARS. The integrated interferon, its mutant and interferon alpha-1b have even high inhibiting effect on new SARS virus.

Nitric oxide generating compounds or compounds which induce in situ synthesis of nitric oxide can be used to inhibit rhinovirus infection. Nitric oxide has the ability to inhibit both viral replication as well as the synthesis of cytokines, in particular the proinflammatory cytokines. Thus the symptoms of rhinovirus infections can be ameliorated by treatments to increase nitric oxide in the respiratory tract.

The invention relates to methods and compositions for preventing or treating human rhinovirus infection.

The present invention relates to methods, compositions and kits for the treatment or prevention of respiratory conditions. In particular, the methods, compositions and kits are particularly useful, but not limited to, the prevention and/or treatment of rhinovirus infection and the prevention and/or treatment of asthma exacerbation. The invention provides a method inhibiting a rhinovirus infection in a subject comprising administering a composition consisting of a compound comprising a TLR2 agonist and a pharmaceutically acceptable carrier.

Methods, kits, and compositions are disclosed for vaccinating a human or animal against human rhinovirus infection. Also provided are methods of using a cotton rat model for identifying and testing vaccines and therapeutic agents that prevent or ameliorate human rhinovirus infection.

The present invention provides ester derivatives of hydroxybenzoic acid for use in the treatment or prevention of a rhinovirus infection in a mammal wherein R represents a C_1-10 alkyl group, X₁, X₂, X₃, X₄ and X₅ independently represent —H or —OH and wherein at least one of X₁, X₂, X₃, X₄ and X₅ is —OH.

The present invention is directed to the use of anti-malarial compound for the treatment and prophylaxis of infections by adenovirus or rhinovirus.

The invention discloses Zukamu granules. The Zukamu granules are prepared from rhizome kaempferiae, nymphaea tetragona, mint, jujubes, chamomile, cordia dichotoma fruits, liquorice, hollyhock seeds, rheum officinale and pericarpium papaveris. The Zukamu granules are used for resisting coxsakievirus and/or rhinovirus infection. The Zukamu granules can effectively inhibit activity of coxsakievirus and rhinovirus, regulate abnormal constitution, clear heat, promote sweating and open orifices and is used for treating cold coughs, fever adiaphoresis, sore throat and nasal congestion.

The present invention provides a pharmaceutical composition for use in prevention or treatment of a human rhinovirus (HRV) infection. The composition comprises an aldohexose, wherein the hydroxyl group at carbon 2 of the aldohexose is replaced by any one of H, F, Cl, Br, I, SH, Me, OMe and SMe, such as a 2-deoxy-glucose. Furthermore, a dispenser for intranasal administration, such as a nasal spray or nose drop applicator containing said pharmaceutical composition is provided. In addition, an inhalation device, such as a metered-dose inhaler, a dry-powder inhaler or a nebuliser, comprising said composition is provided.