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Medicament for accelerated wound healing

A wound healing and drug technology, applied in the direction of drug combination, drug delivery, active ingredients of hydroxyl compounds, etc., can solve the problems of scarcity of natural sandalwood oil and expensive raw materials

Inactive Publication Date: 2017-05-17
SYMRISE GMBH & CO KG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It should be noted that due to its widespread use as a perfume ingredient, natural sandalwood oil has become a rare and very expensive ingredient

Method used

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  • Medicament for accelerated wound healing
  • Medicament for accelerated wound healing
  • Medicament for accelerated wound healing

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Experimental program
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Effect test

Embodiment Construction

[0128] Characterization of OR2AT4 in a heterologous expression system

[0129] In order to define the function of a receptor in tissue, it is important to understand the ligand to ensure the ability of the receptor to be activated in the native system. Most ORs have not been de-orphaned so far. Therefore OR2AT4 identified in human keratinocytes was first characterized more accurately in a heterologous expression system and the receptor domain was determined.

[0130] Heterologous expression of OR2AT4 in Hana3A‐cells

[0131] Hana3A-cells stably expressing endogenous olfactory transduction factors were used as a heterologous expression system, which targetedly assist OR to insert into the cell membrane and improve its activity. In addition, the addition of the first N-terminal amino acid at position 20 of the rhodopsin (Rho-tag) to the N-terminus of the OR coding sequence was also used to facilitate heterologous expression.

[0132] To detect heterologous expression of OR2AT...

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Abstract

A medicament for accelerated wound healing is proposed containing derivatives of the formula (I), in which R1 stands for hydrogen or methyl.

Description

[0001] field of invention [0002] The present invention belongs to the field of medicine and relates to a medicine especially for accelerating wound healing, which contains a compound with the smell of sandalwood. Background technique [0003] Wound healing is the endogenous process of the body that seals wounds by maximizing the restoration of damaged body tissue. This is a natural biological process that begins only minutes after injury, as can be determined by enzymatic histochemistry. Platelets arrive at the injured area and try to seal the wound. Scabbing occurs in some cases by exudate (fluid secretion), which often causes itching that accompanies wound healing. [0004] Wound healing is divided into different stages. After the damaged vessel has been closed by coagulation, no macroscopic or microscopically visible reactions initially occur. The first latent stage transitions into the exudative stage, in which foreign bodies and bacteria are washed out of the wound ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61P17/02G01N33/58G01N33/50
CPCA61K9/0014A61K31/045G01N33/5008G01N33/582A61P17/02
Inventor 丹妮拉·布塞海克·康拉德汉斯·哈特
Owner SYMRISE GMBH & CO KG