Suppository composition for treating vaginitis

A composition and technology of vaginitis, applied in the field of pharmaceutical preparations, can solve the problems affecting the daily life and work of female patients, repeated attacks of candida vaginitis, high incidence of bacterial vaginosis, etc., and achieve long-lasting relief and good treatment Effect, the effect that the antibacterial effect is remarkable

Inactive Publication Date: 2017-05-31
ZHUHAI JUJIAO XIANDAO BIOLOGICAL RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, trichomonas vaginitis will have metronidazole-resistant strains, which are ineffective for metronidazole treatment; candida vaginitis will recur and cannot be cured for a long time; the incidence of bacterial vaginosis is high, which often seriously affects the daily life and work of female patients , and even cause some psychological problems
However, these problems will not endanger the lives of patients, so they are often ignored by doctors. Therefore, the research on these diseases is not extensive and in-depth, and there are not many studies on their pathogenesis.

Method used

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  • Suppository composition for treating vaginitis
  • Suppository composition for treating vaginitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) 200g sodium carboxymethylcellulose and 300g carrageenan are mixed evenly;

[0023] (2) Add 1000g of deionized water, 30g of glycerin, and 15g of polysorbate-80 into (1), and stir thoroughly at a temperature of 50°C to 85°C to prepare a composite gel matrix;

[0024] (3) Slowly add 50 g of the pharmaceutical composition (20 g of catechin, 3 g of metronidazole, 9 g of clindamycin, 15 g of matrine, and 3 g of nonoxynol) into (2), stir evenly, and inject mould, cooled and solidified to obtain the suppository of the present invention.

Embodiment 2

[0026] (1) 200g sodium carboxymethylcellulose and 400g carrageenan are mixed uniformly;

[0027] (2) Add 1000g of deionized water, 30g of glycerin, and 15g of polysorbate-80 into (1), and stir thoroughly at a temperature of 50°C to 85°C to prepare a composite gel matrix;

[0028] (3) Slowly add 92g of the pharmaceutical composition (catechin 35g, metronidazole 2.5g, clindamycin 11.5g, matrine 40g, nonoxynol 3g) into (2), after stirring evenly , injected into a mould, cooled and solidified to obtain the suppository of the present invention.

Embodiment 3

[0030] (1) 200g sodium carboxymethylcellulose and 350g carrageenan are mixed uniformly;

[0031] (2) Add 1000g of deionized water, 30g of glycerin, and 15g of polysorbate-80 into (1), and stir thoroughly at a temperature of 50°C to 85°C to prepare a composite gel matrix;

[0032] (3) Slowly add 90g of the pharmaceutical composition (catechin 40g, metronidazole 2g, clindamycin 14.5g, matrine 30g, nonoxynol 3.5g) into (2), after stirring , injected into a mould, cooled and solidified to obtain the suppository of the present invention.

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PUM

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Abstract

The invention discloses a suppository composition for treating vaginitis. The suppository composition mainly comprises catechinic acid, carrageenan, metronidazole, clindamycin, sophocarpidine and nonoxynol. The suppository has the characteristics of being convenient to use and good in slow-release property and can be used for treating vaginitis of women.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a suppository composition for treating vaginitis. Background technique [0002] Among many reproductive tract infection diseases, vaginitis is the most common among women, and its incidence is increasing year by year. Living environment, hygiene habits, climate change, and drug effects all have a significant impact on its incidence. Vaginitis is generally divided into trichomonas vaginitis, candida vaginitis, bacterial vaginosis and senile vaginitis. At present, the overall characteristics of vaginitis are: no obvious symptoms, 10%-40% of patients with bacterial vaginosis are asymptomatic, 25%-50% of trichomonas vaginitis are asymptomatic in the early stage, almost all chlamydia and gonorrhea infections are asymptomatic ; But the incidence rate is relatively high, about 35.8%-85.1%; and patients are taboo to see a doctor, embarrassed to see a doctor, thus delaying the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K47/36A61K31/353A61K31/4164A61K31/7056A61K31/4375A61K31/085A61P15/02A61P31/04
CPCA61K9/02A61K9/0034A61K31/085A61K31/353A61K31/4164A61K31/4375A61K31/7056A61K47/36A61K2300/00
Inventor 宋诗丽其他发明人请求不公开姓名
Owner ZHUHAI JUJIAO XIANDAO BIOLOGICAL RES INST CO LTD
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