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Fenbendazole suspension and preparation method thereof

A technology for fenbendazole and suspensions, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, and medical preparations containing active ingredients. Solve the problem of single suspending agent, achieve good resuspendability, mild operating conditions, and close steps

Active Publication Date: 2017-05-31
JIANGXI BOLAI PHARMACY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, fenbendazole is generally in the form of a suspension, but the storage time of the suspension is relatively short, and stratification will occur after standing for a period of time, and there will be clots in the suspension. In the pre-preparation process, water is generally used as the wetting agent in the early stage, resulting in incomplete wetting of fenbendazole, and the suspending agent contained in the suspension is relatively simple, and the redispersion performance in the later stage is not good, and the wall hanging phenomenon is serious. The occurrence of these conditions will affect the efficacy of fenbendazole itself

Method used

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  • Fenbendazole suspension and preparation method thereof
  • Fenbendazole suspension and preparation method thereof
  • Fenbendazole suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation method of fenbendazole suspension is as follows:

[0031] 1) Prescription quantity: fenbendazole 8g, glycerin 22ml, methylcellulose 0.2g, xanthan gum 0.1g, Tween-80 1.5g, Span-80 1.5g, sodium benzoate 0.1g, citric acid 1g, Quantitative water to 100ml;

[0032] 2) Weigh the prescribed amount of fenbendazole, add glycerin, Tween-80, and Span-80 for wetting, and wait until the wetting is complete;

[0033] 3) Take 50ml of water, add sodium benzoate and citric acid and stir to dissolve, then add methyl cellulose and disperse for 2 minutes with a high-speed homogeneous disperser;

[0034] 4) Mix and stir the mixed liquid in step 3) and the mixed liquid in step 2) evenly, disperse for 1 min with a high-speed homogeneous disperser, add water to a quantitative amount of 100ml, and disperse for 2 min with a high-speed homogeneous disperser to obtain the product.

Embodiment 2

[0036] The preparation method of fenbendazole suspension is as follows:

[0037] 1) Prescription quantity: fenbendazole 12g, glycerin 10ml, methylcellulose 0.1g, xanthan gum 0.8g, dextran-403g, Tween-80 0.5g, Span-80 0.6g, sodium benzoate 0.3g, 3g of citric acid, water quantitatively to 100ml;

[0038] 2) Weigh the prescribed amount of fenbendazole, add glycerin, Tween-80, and Span-80 for wetting, and wait until the wetting is complete;

[0039] 3) Take 50ml of water, add sodium benzoate, citric acid, and dextran-40 and stir to dissolve, then add methylcellulose and xanthan gum, disperse for 3 minutes with a high-speed homogeneous disperser, and control the temperature at 30°C;

[0040] 4) Mix and stir the mixed liquid in step 3) and the mixed liquid in step 2) evenly, disperse with a high-speed homogeneous disperser at 20°C for 2 minutes, add water to 100ml, and disperse with a high-speed homogeneous disperser at 30°C for 3 minutes to obtain the product.

Embodiment 3

[0042] The preparation method of fenbendazole suspension is as follows:

[0043] 1) Prescription quantity: fenbendazole 9g, glycerin 15ml, methylcellulose 0.7g, xanthan gum 0.1g, dextran-402.5g, Tween-80 0.7g, Span-80 0.7g, sodium benzoate 0.25g , citric acid 2.5g, water quantitatively to 100ml;

[0044] 2) Weigh the prescribed amount of fenbendazole, add glycerin, Tween-80, and Span-80 for wetting, and wait until the wetting is complete;

[0045] 3) Take 50ml of water, add sodium benzoate, citric acid, dextran-40 and stir to dissolve, then add methyl cellulose and xanthan gum, disperse for 3 minutes with a high-speed homogeneous disperser, and control the temperature at 20°C;

[0046] 4) Mix and stir the mixed liquid in step 3) and the mixed liquid in step 2) evenly, disperse with a high-speed homogeneous disperser at 30°C for 2 minutes, add water to a certain amount to 100ml, and disperse with a high-speed homogeneous disperser at 20°C for 3 minutes to obtain the product. ...

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Abstract

The invention provides a fenbendazole suspension. The suspension per 100ml mainly comprises 8-12g of fenbendazole, 10-25ml of glycerinum, 0.1-0.7g of methylcellulose, 0.1-1.5g of xanthan gum, 0-3g of dextran-40, 0.1-1.5g of tween-80, 0.6-1.5g of span-80, 0.1-0.3g of sodium benzoate, 1-3g of citric acid and the balance of water. A preparation method comprises the following steps: mixing and wetting fenbendazole with glycerinum, tween-80 and span-80 to form mixed liquid; and after partially dissolving sodium benzoate, citric acid and dextran-40 with part of water, adding methylcellulose and xanthan gum and uniformly mixing, mixing the mixture with the mixed liquid, and then adding residual water and uniformly mixing to obtain the suspension.

Description

technical field [0001] The invention relates to the field of preparation of fenbendazole suspension, in particular to a fenbendazole suspension and a preparation method thereof. Background technique [0002] Fenbendazole is a benzimidazole antiparasitic drug, which not only has a high degree of anthelmintic activity against gastrointestinal nematode adults and larvae, but also has good effects on Dictyocaulus, Fasciola and tapeworms. Strong insecticidal effect, fenbendazole is white or off-white powder, odorless, tasteless, insoluble in water, but soluble in glacial acetic acid and dimethyl sulfoxide, slightly hygroscopic, and dry state It is stable and heat-resistant, and its properties are also stable when the pH is 2-6. [0003] Fenbendazole has been widely used at home and abroad. The fenbendazole drug binds to the microtubulin of the worm body to prevent the polymerization of microtubules, thereby causing damage to the microtubules of the epidermis and intestinal cytop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/4184A61K47/38A61K47/26A61K47/36A61K47/10A61P33/10
Inventor 唐进波李艳梅张付华熊俊芳肖欣戈姜恒陈齐杰肖兴丽胡国彬胡瑞玲
Owner JIANGXI BOLAI PHARMACY CO LTD
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