Multi-drug delivery retinoic acid nanoparticle solution and preparation and application thereof
A nanoparticle, retinoic acid technology, applied in the directions of drug delivery, pharmaceutical formulation, powder delivery, etc., can solve problems such as retinoic acid tolerance, and achieve the effects of clear mechanism of action, reasonable collocation, and simple preparation process
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Embodiment 1
[0023] Dissolve 30.0 mg of all-trans retinoic acid, 26.4 mg of vorinostat, 46.2 mg of perifosine, 1.00 g of poloxamer 188, and 7 μl of ethylenediamine in 20 ml of hot ethanol. Under high-speed stirring, the ethanol solution was slowly added to 80 ml of water, and the ethanol was removed by rotary evaporation to obtain nanoparticles dispersed in water.
Embodiment 2
[0025] 300 mg of 9-cis retinoic acid, 26.4 mg of vorinostat, 46.2 mg of perifosine, 400 mg of polycaprolactone, 1.60 g of Tween 80 were dissolved in a mixture consisting of 10 ml of ethanol and 10 ml of acetone. Under high-speed stirring, the above solution was slowly added to 80 ml of water, and the acetone and ethanol were removed by dialysis to obtain nanoparticles dispersed in water.
Embodiment 3
[0027] Dissolve 30 mg of all-trans retinoic acid, 105.6 mg of vorinostat, 46.2 mg of perifosine, and 300 mg of polycaprolactone-polyethylene glycol block copolymer in a mixture consisting of 10 ml of ethanol and 10 ml of acetone. Under high-speed stirring, the above solution was slowly added to 80ml of water, and most of the acetone and ethanol were removed by low-temperature evaporation under vacuum, and then freeze-dried to obtain nanoparticle powder.
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