Combination of a PD-1 antagonist and a listeria-based vaccine for treating prostate cancer

A technology for prostate cancer and Listeria, which is applied in the field of combination therapy for the treatment of cancer and the antagonist of programmed death 1 protein, which can solve the problems of weakening tumor immune response, weakening T cell activation and immune surveillance, etc.

Inactive Publication Date: 2017-08-01
ADVAXIS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, PD-L1-expressing tumor cells have been proposed to interact with PD-1-expressing T cells to attenuate T cell activation and evade immune surveillance, resulting in a weakened immune response to tumors

Method used

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  • Combination of a PD-1 antagonist and a listeria-based vaccine for treating prostate cancer
  • Combination of a PD-1 antagonist and a listeria-based vaccine for treating prostate cancer
  • Combination of a PD-1 antagonist and a listeria-based vaccine for treating prostate cancer

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[0422] A Phase 1-2 Dose-Escalation and Safety Study of ADXS31-142 Alone and in Combination with Pembrolizumab (MK-3475) in Patients with Previously Treated Metastatic Castration-Refractory Prostate Cancer (mCRPC)

[0423] This is a Phase 1-2, open-label, multicenter, nonrandomized, two-part study in patients with metastatic castration-resistant prostate cancer (mCRPC). Part A of the study will be an open-label, Phase 1, multicenter, non-randomised, dose-determining trial of ADX31-142 monotherapy in subjects with metastatic castration-resistant prostate cancer (mCRPC). Part B of the study will be an open-label, Phase 1-2, multicenter, non-randomized, dose-determining trial of ADXS31-142 in combination with pembrolizumab (MK-3475) in subjects with mCRPC. Figure 10 A schematic diagram of the monotherapy and combination portions of the study is shown.

[0424] Purpose:

[0425] Part A: Assess the safety and tolerability of ADXS31-142 monotherapy and select the recommended Phase...

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Abstract

The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a Listeria based strain that expresses prostate-tissue specific antigen (PSA), and the use of the combination therapies for the treatment of prostate cancer.

Description

technical field [0001] The present invention relates to combination therapies useful in the treatment of cancer. In particular, the present invention relates to the combination of an antagonist of programmed death 1 protein (PD-1) and a live attenuated recombinant Listeria strain for the treatment of prostate cancer, the live attenuated recombinant Listeria strain comprising A fusion protein formed by fusing the polypeptide of the PEST sequence or the peptide containing the PEST sequence to a tumor-associated antigen. Background technique [0002] PD-1 is considered to play an important role in immune regulation and maintenance of peripheral tolerance. PD-1 is moderately expressed on unexposed T, B, and NKT cells and is upregulated by T / B cell receptor signaling on lymphocytes, monocytes, and myeloid cells (1). [0003] Two known ligands of PD-1, PD-L1 (B7-H1) and PD-L2 (B7-DC), are expressed in human cancers arising in various tissues. In large sample groups such as ovar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/02A61K35/74A61K39/12A61P35/00
CPCA61K2039/522A61P35/00A61K39/39558A61K2039/523A61K2039/572A61K39/001194A61K2039/884A61K2300/00A61K39/0011
Inventor R·佩蒂D·J·毛罗R·F·佩里尼
Owner ADVAXIS
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