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Phenolic amide I, and extraction method and application thereof

A technology for phenolamide and phenolamide description, which is applied in the field of traditional Chinese medicine extraction and can solve the problems that the extraction method and use of phenolamide have not been reported yet.

Inactive Publication Date: 2017-08-04
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the extraction of phenolamide I from the persistent calyx and fruit of Pseudomonas pseudophysalis and its extraction method and application have not been reported yet.

Method used

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  • Phenolic amide I, and extraction method and application thereof
  • Phenolic amide I, and extraction method and application thereof
  • Phenolic amide I, and extraction method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The extraction method of phenolamide I is characterized in that comprising the steps:

[0034] (1) take the dry persistent calyx and I fruit (4.5kg) of pseudophysalis as raw materials, add a volume fraction of 12 mass times of raw materials and be 70% ethanol aqueous solution, reflux extraction 2 times, extract 2 hours each time, merge to obtain the extract, Recover solvent under reduced pressure, obtain total extract (550g) after concentrating;

[0035] (2) Disperse the total extract into 5 times by mass of water, extract with sherwood oil and ethyl acetate successively, and recover the solvent under reduced pressure from the ethyl acetate extract to obtain the ethyl acetate layer extract (102g);

[0036] (3) The extract from the ethyl acetate layer was separated by silica gel column chromatography, and the dichloride dichlorides with volume ratios of 100:1, 100:2, 100:5, 100:10, 5:1, 2:1 and 1:1 were respectively Gradient elution with methane-methanol as the eluent t...

Embodiment 2

[0049] The extraction method of phenolamide I comprises the steps:

[0050] (1) Use the dried calyx and fruit of Physalis pseudophysalis as raw materials, add 80% ethanol aqueous solution with a volume fraction of 8 mass times of the raw materials, reflux extraction twice, extract for 2 hours each time, combine to obtain the extract, and recover the solvent under reduced pressure, Obtain the total extract after concentration;

[0051] (2) Disperse the total extract into water of 5 times by mass, extract with equal volumes of petroleum ether and ethyl acetate successively, and recover the solvent under reduced pressure from the ethyl acetate extract to obtain the ethyl acetate layer extract;

[0052] (3)-(6) are the same as embodiment 1(3)-(6).

Embodiment 3

[0054] The extraction method of phenolamide I comprises the steps:

[0055] (1) Use the dried calyx and fruit of Physalis pseudophysalis as raw materials, add 10 mass times of raw materials with a volume fraction of 60% ethanol aqueous solution, reflux extraction for 3 times, extract for 2 hours each time, combine to obtain the extract, and recover the solvent under reduced pressure, Obtain the total extract after concentration;

[0056] (2) Disperse the total extract into 10 mass times of water, extract with equal volumes of petroleum ether and ethyl acetate successively, and recover the solvent under reduced pressure from the ethyl acetate extract to obtain the ethyl acetate layer extract;

[0057] (3)-(6) are the same as embodiment 1(3)-(6).

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Abstract

The invention discloses a phenolic amide I, and an extraction method and an application thereof. The compound has a structure as shown in a formula (I) in the specification. The compound and a composition thereof have an obvious protecting action on cellular damage of human neuroblast (SH-SY5Y) induced by MPP+. The compound can be used as a drug for preventing and treating Parkinson's disease and has a good research and development prospect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine extraction, and relates to a phenolamide I, an extraction method and application thereof. Background technique [0002] Nicandra physaloides (Nicandra physaloides) is an annual herbaceous plant belonging to the family Solanaceae. It is native to Peru. In my country, it is mainly distributed in Yunnan, Guangxi and other places, and it is also cultivated in Guizhou. Pseudophysalis is a kind of Chinese herbal medicine with both medicinal and edible properties. The whole plant has sedative, expectorant, heat-clearing, detoxifying, and cough-relieving effects, and can treat mental illness, rabies, colds, rheumatism, scabies and other diseases. The seeds are used as medicine, called pseudophysalis seeds, which have the effects of clearing heat and annealing, diuretic, expelling wind, and anti-inflammatory, and can treat fever, rheumatoid arthritis, sores, carbuncles, swelling and pain. The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/80A61K31/343A61K36/81A61P25/16A61P25/00
CPCC07D307/80A61K36/81
Inventor 陈丽霞李华王莉晴高苏钰王莹
Owner SHENYANG PHARMA UNIVERSITY
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