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diafiltration system and diafiltration method
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A technology of percolation and permeate, applied in the field of percolation system, which can solve problems such as the decrease of electrical conductivity
Active Publication Date: 2020-03-03
PALL CORP
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Where water is used for diafiltration, the salts will be washed out and the conductivity will drop
Method used
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example 1
[0056] This example demonstrates that, in accordance with an embodiment of the present invention, with controlled percolation fluid flow (in each channel), from a The feed stream achieved 99% (2-log; NDV=7) removal of impurities.
[0057] The diafiltration system is configured to include a fluid treatment assembly generally as shown in FIG. 4 (A and B), wherein the diafiltration pump and diafiltration system are configured substantially as Figure 1A and 1C Shown in, includes MASTERFLEX L / S Precision Variable Speed Pump Driver (Model: EW-07528-30), and three MASTERFLEX L / S Multi-Channel Pump Heads (Model: 07536-002) and MASTERFLEX L / S High Performance Precision 2-stop tube set (L / S 15, 06421-15) (Cole-Palmer Instrument Company, Vernon Hills, IL).
[0058] The fluid processing module has 6 stages, each stage has 2 cross-flow processing modules in series, each cross-flow processing module includes Delta regenerated cellulose UF membranes, each membrane has a cutoff of 30kDA a...
example 2
[0066]This example demonstrates that, in accordance with an embodiment of the present invention, with controlled percolation fluid flow (in each channel), from a The feed stream achieved 99.9% (3-log; NDV=13) removal of impurities.
[0067] The diafiltration system, fluid treatment components, and feed and DF solutions were as described in Example 1.
[0068] When the feed fluid flow rate is 5mL / min, the percolation fluid flow rate in each channel is about 10.8mL / min, and when the feed fluid flow rate is 10mL / min, the percolation fluid flow rate in each channel is about 22.7mL / min.
[0069] By employing retentate throttling, an approximately 1:1 ratio between feed flow and retentate flow is maintained.
[0070] The result is as follows:
[0071] For a feed fluid flow rate of 5 mL / min, for DF stages 1-6, the flow distribution of each DF stage remained substantially uniform at around 10 mL / min. The pressures for DF grades 1 and 2 were 15 psig and 17 psig respectively, the pr...
example 3
[0075] This example demonstrates that impurity is achieved from a feed stream having a fluid flow rate of 5 mL / min with the percolation fluid flow rate (in each channel) controlled to be about 18.3 mL / min according to one embodiment of the present invention. 99.99% (4-log; NDV=22) of was removed.
[0076] The diafiltration system, fluid treatment components, and feed and DF solutions were as described in Example 1.
[0077] By employing retentate throttling, an approximately 1:1 ratio between feed flow and retentate flow is maintained.
[0078] The result is as follows:
[0079] For DF stages 1-6, the flow profile of each DF stage was kept in the range of about 8-12 mL / min. The pressure profile varied from about 34 psig for DF stage 1 to about 26 psig for DF stage 6 (down about 1 to 2 psig per stage towards the retentate outlet).
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Abstract
Diafiltration systems and diafiltration methods. The diafiltration system includes: a fluid treatment assembly comprising two or more fluid treatment modules, the fluid treatment assembly including a feed inlet, a permeate outlet, and a retentate outlet; each module including a cross flow treatment assembly and a percolation fluid distribution plate, A cross-flow processing module comprising an ultrafiltration membrane and having a feed side and a permeate side, a permeate distribution plate comprising a permeate feed inlet and a common feed permeate / permeate permeate outlet port; two or more a plurality of percolation fluid conduits each in fluid communication with a respective single percolation fluid feed inlet; and a percolation fluid pump comprising at least a first multi-channel pump head, the first multi-channel pump head having at least two passages, the at least two passages comprising separate passages for separate conduits in fluid communication with respective single percolation fluid feed inlets, wherein the pump provides a pump through each conduit to the respective percolation fluid feed inlet Simultaneously controlled percolation fluid flow.
Description
technical field [0001] The present invention relates to a diafiltration system and a diafiltration method. Background technique [0002] Diafiltration is the use of ultrafiltration (UF) membranes to remove, replace, or reduce unwanted materials such as salts and / or solvents from fluids containing desired materials, such as desired biomolecules such as proteins, peptides, and nucleic acids. Techniques for the concentration of undesired materials such as salts and / or solvents. UF membranes retain molecules larger than the pores of the membrane (the solution containing the retained molecules is called the retentate or concentrate) and smaller molecules such as salts, solvents and water (which are 100% permeable) pass freely Membrane (provides a solution called permeate or filtrate). [0003] Continuous diafiltration (sometimes called constant volume diafiltration) involves removing the original buffer salt (and / or other buffer) from the retentate by adding water or new buffer...
Claims
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