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Noninvasive skin wound sampling observation and analysis method

An analysis method and skin wound technology, which are applied in the field of clinical wound sampling, observation and analysis to achieve the effects of convenient comparison and analysis, convenient operation, convenient use and safety

Inactive Publication Date: 2017-08-18
钟叔平 +2
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  • Abstract
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  • Application Information

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Problems solved by technology

However, this method only stays at the observation and detection of surface characteristics such as the color, shape and size of the wound, and is an effective method for the analysis of tissue cell proliferation, necrosis, autophagy and apoptosis, and related Bio-Marker molecules during the treatment of patient wounds. So far, it is lacking, and it is urgent to invent a simple, non-invasive and easy-to-use observation method for skin wound damage and repair effect, so that it can be used to evaluate the molecular mechanism of skin damage in real time and objectively during the treatment process and to judge the curative effect of surgery or drugs

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  • Noninvasive skin wound sampling observation and analysis method

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Embodiment example

[0055] Case 1: Analysis of exfoliated cells from wounds of patients with diabetic foot: samples from patients with diabetic foot were collected and stained with DAPI to observe the changes in the karyotype of exfoliated cells.

[0056] Analysis of exfoliated cells from wounds of diabetic foot patients: samples from diabetic foot patients were collected and stained with DAPI to observe the changes in the karyotype of exfoliated cells. figure 1 Observation of the karyotype of exfoliated cells in the skin of diabetic foot patients: A. Necrotic tissue; B. Exfoliated cells with nuclear fragmentation (arrows); C, D gradually repaired wound tissue (DAPI staining, observed under a fluorescent microscope, bar =50μm).

[0057] Specific steps:

[0058] 1) Clean the wound surface, clean up the wound secretions, and then use a cotton swab moistened with normal saline for injection to sample. For a smooth wound surface, use a cotton swab to rotate at a constant speed on the wound surface t...

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Abstract

The invention discloses a noninvasive skin wound sampling observation and analysis method. Exfoliative cells of wound tissues of a patient are glued by using a glass slide, are fixed and dyed and a patch is analyzed. The observation and analysis method is simple in implement process, convenient to operate, free of special instrument or equipment, convenient and safe to use, and convenient to popularize in a primary medical network. Meanwhile, the observation and analysis method is scientific and advanced; observation of the curative effect on a patient in the treatment process from the tissue level, the cell level and the molecular level can be achieved by using a simple operation; and healing of the wound is objectively and scientifically recorded and judged. The difference in doctors in the cognitive level is avoided and teaching instruction for medical students is also facilitated; system recording of cases in the treatment process can be achieved, comparison and analysis of different cases are facilitated; evaluation of the curative effect of a new drug is also facilitated; and these advantages are not clinically available today.

Description

technical field [0001] The invention relates to a non-invasive, simple and easy-to-use clinical wound sampling observation and analysis method, which can be applied to wounds caused by various reasons, skin ulcers, pressure sores and other wounds, as well as wound treatment. The effect of the repair. Background technique [0002] At present, there is no definite and objective evaluation method for wound condition and repair effect. Doctors usually rely on naked eye observation to judge the treatment effect based on experience. There is still a lack of accurate and objective evaluation system and standards. It not only exists in the cognition among clinicians It is also difficult to compare patients horizontally, let alone judge the changes in epidermal tissue during treatment. The Chinese patent application number 201010219014.4 discloses a method for comprehensive detection of skin wounds, including: obtaining the standard value of a three-dimensional measuring ruler; phot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/84G01N21/64G01N1/30
CPCG01N1/2806G01N1/30G01N21/6486G01N21/84
Inventor 钟叔平郭菲郭光华
Owner 钟叔平
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