Unlock instant, AI-driven research and patent intelligence for your innovation.

Apparatus and methods for analyzing the output of a microfluidic device

一种微流体装置、微流体通道的技术，应用在微流体领域，能够解决不容易修改以监测、复杂光学器件等问题

Active Publication Date: 2021-08-31
THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these techniques require complex optics and are not easily modified to monitor more than one channel

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Apparatus and methods for analyzing the output of a microfluidic device
  • Apparatus and methods for analyzing the output of a microfluidic device
  • Apparatus and methods for analyzing the output of a microfluidic device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0041] Aspects of the invention relate to apparatus and methods for analyzing the output of a microfluidic device.

[0042] The inventors have realized that it would be useful to provide a full analysis of the output of a microfluidic device. The present inventors have also realized that using a different micropatterned mask for each channel of the microfluidic device to encode the signal from the output, such as a droplet, enables the recovery of weak signals without the need for expensive and bulky photodetectors . The present inventors have also realized that the use of masks allows multiple channels to be monitored simultaneously, allowing increasingly complex experiments without the need for additional and expensive detection hardware such as lenses, lasers and complex fluid control hardware. In particular, the microfluidic devices of the present invention can use a single detector to measure droplets in multiple channels, even simultaneously, and do not require lenses o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Microfluidic devices for analyzing microdroplets are disclosed. The described microfluidic device includes a substrate and microfluidic channels formed on the substrate. The microfluidic channel includes channels, wherein each channel has a mask pattern configured to modulate a signal of a droplet passing through the channel such that a droplet passing through the channel generates a signal. The microfluidic device also includes a detector configured to detect the signal. A method of analyzing droplets using a microfluidic device having microfluidic channels formed on a substrate is disclosed. The described method includes: passing a droplet through a via; using a mask pattern formed on the via; modulating a signal from the droplet; and detecting the signal.

Description

[0001] Cross References to Related Applications [0002] This PCT application claims priority to US Provisional Patent Application No. 62 / 037,273, filed August 14, 2014, the disclosure of which is hereby incorporated by reference in its entirety for all purposes. technical field [0003] The present invention relates to the field of microfluidics, and more particularly to devices and processes for analyzing the output of microfluidic devices, such as droplets. Background technique [0004] Droplet-based assays using microscale emulsions as isolated compartments to run multiple independent chemical reactions have gained popularity in recent years as platforms for a wide range of biomedical applications. Micron-sized droplets contain only (10-12L) picoliters of fluid, providing 10 6 doubled down. Further, microfluidics allows processing at up to 10 6 The rate to create droplets, thereby providing the number of compartments greater than 10 of the conventional technology 4 t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/63
CPCB01L3/502715G01N21/6428B01L3/502784B01L2300/0627B01L2300/0861B01L2300/0654G01N2015/1481G01N21/6486G01N2201/063G01N27/221G01N27/74G01N29/022
Inventor 大卫·伊萨多尔梅拉库·穆伦内·沃尔德马里亚姆
Owner THE TRUSTEES OF THE UNIV OF PENNSYLVANIA