Application of fingolimod and structural analogue of fingolimod in preparing drug for treating cerebral hemorrhage
A technology similar in structure to fingolimod hydrochloride, applied in the field of fingolimod and its structural analogues, can solve the problems of no cerebral hemorrhage and achieve significant curative effect and highlight the promotion prospect
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Embodiment 1
[0032] 1. Preparation of drugs
[0033] Take 50g of fingolimod and 2450g of starch, mix 950g of starch with water to make a thin slurry, then gradually add the remaining starch and all of fingolimod to the slurry under stirring, stir all the ingredients evenly, make granules, and then Sieve, dry, and pack into capsules.
[0034] 2. Selection of experimental objects
[0035] Between March 2013 and December 2013, 11 patients with spontaneous subtentorial parenchymal hemorrhage with onset time less than 72 hours, hematoma volume between 5ml and 30ml, Glasgow coma index not less than 6, and no heart rhythm Patients with abnormalities, macular edema, tumors and immunosuppressants were used as experimental subjects, and 12 people were matched with clinical and imaging characteristics as controls.
[0036] 3. Experimental method
[0037] Patients were divided into fingolimod treatment group and control group, the control group received standard cerebral hemorrhage treatment; fingo...
Embodiment 2
[0051] Take 50g of fingolimod and 2450g of starch, mix 950g of starch with water to make a thin slurry, then gradually add the remaining starch and all of fingolimod to the slurry under stirring, stir all the ingredients evenly, make granules, and then Sieve and dry to form granules.
Embodiment 3
[0053] Take 50g of fingolimod, 2300g of starch, and 150g of magnesium stearate, mix 950g of starch and water to make a thin slurry, and then gradually add the remaining starch, all of fingolimod and all of the stearin to the slurry while stirring Magnesium acid, all stirred evenly, dried and compressed into tablets, film-coated to form tablets.
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