32 results about "Lymphocyte infiltration" patented technology

The present invention proposes a radiomics-based biomarker for detecting the presence and the density of tumor infiltrating CD8 T-cells in a solid tumor without having to use any biopsy of said tumor.The invention also proposes to use this information to assess the immune phenotype of said solid tumor. In a particular embodiment, the invention proposes to prognose the survival and / or the treatment efficiency of cancer patients treated with immunotherapy such as anti-PD-1 / PD- L1 monotherapy.

Provided is a compound which has an excellent S1P1 agonist action, and is useful particularly as an active ingredient for an agent for preventing and / or treating a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells. According to the present invention, a 2H-chromene compound or a derivative thereof which has an excellent S1P1 agonist action, and is useful particularly as an active ingredient of an agent for preventing and / or treating a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells can be provided. The 2H-chromene compound and a derivative thereof which are the compounds of the present invention have an S1P1 agonist action, and can be used particularly for prevention and / or treatment of a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells.

The invention provides a new application of fingolimod and an analogue thereof in preparing medicines for treating cerebral infarction and further shows the mechanism of treatment, effective dose, suitable dosage form and the specific compound of the analogue. Experiments confirm that the fingolimod and the analogue thereof can relieve lymphocyte infiltration caused by cerebral infarction, the relieving effect can be taken as a new target for treating cerebral infraction, furthermore, based on the new properties of the fingolimod and the analogue thereof, the new application of the fingolimod and the analogue thereof in preparing medicines for treating cerebral infraction is confirmed. The clinical applicability of the fingolimod and the analogue thereof is enlarged, the fact that the immune cells involve in cerebral infarction pathological lesion is disclosed, and the medicine prepared by the fingolilmod and the analogue thereof has a remarkable curative effect on cerebral infraction injure, and has prosperous generalization prospect.

The present invention relates to use of osthole for manufacturing a composition for treating focal segmental glomerulosclerosis (FSGS). Particularly, the present invention discloses that osthole is effective in treating focal segmental glomerulosclerosis (FSGS), which can alleviate various symptoms and signs of FSGS, including proteinuria, renal fibrosis, glomerular epithelial hyperplasia lesion (EPHL), and macrophage / lymphocyte infiltration in the kidney, etc.

The invention provides a novel application of fingolimod and structural analogue of fingolimod in preparing a drug for treating cerebral hemorrhage, and further determines a treatment mechanism, an active dose and an appropriate dosage form and a specific compound pointed by the structural analogue. The nature of the fingoliimod and the structural analogue of the fingolimod for alleviating lymphocytes infiltration caused by cerebral hemorrhage is made clear by virtue of experimental means, and the alleviation effect is ensured to be used as a novel target spot for treating the cerebral hemorrhage, so that the novel application of the fingolimod and the structural analogue of the fingolimod in preparing the drug for treating the cerebral hemorrhage is determined on the basis of the novel nature f the fingolimod and the structural analogue of the fingolimod. The novel application of the invention enlarges the clinical applicability of the fingolimod and the structural analogue of the fingolimod, and discloses the fact that the immune cells anticipate in the cerebral hemorrhage pathological lesion, and the drug prepared by the invention is significant in curative effect for the cerebral hemorrhage and has remarkable popularization prospect.

The invention discloses an application of Cbl-b protein in preparation of a product with a protective effect on lung injury induced by tobacco smoke. The product with a protective effect on lung injury induced by tobacco smoke is a medicine for promoting Cbl-b protein expression. The invention also discloses a medicine with the protective effect on lung injury induced by tobacco smoke, and the medicine is beneficial to protecting lung injury induced by tobacco smoke, slowing down the decline of lung function, reducing lung tissue macrophage and lymphocyte infiltration, relieving lung tissue inflammatory response, reducing the degree of emphysema; and slowing the epithelial-mesenchymal transition process of lung tissues.

The invention provides application of ribavirin in preparing a medicine for treating ischemic cerebral apoplexy. Upon experimental means, the ribavirin can achieve an effect on treating inflammations by relieving a lymphocytes infiltration phenomenon caused by the ischemic cerebral apoplexy, and subsequently a therapeutic effect can be achieved on the ischemic cerebral apoplexy. According to the invention, the clinical applicability of the ribavirin and structural analogues thereof is widened; and the internal principle that lymphocytes participate in the pathological damage of the ischemic cerebral apoplexy is revealed. The medicine disclosed by the invention, through oral administration, can significantly diminish the necrosis volume of brain tissue, reduce inflammatory exudation amount of intra-cerebral vessels and relieve an edema phenomenon of the brain tissue; and the medicine has a significant curative effect on the ischemic cerebral apoplexy and has an outstanding prospect of popularization.

In the invention, selecting MIP-1alpha as guide molecule, active segment DT390 of diphtheria toxin as toxin molecule, constructing eukaryon plasmid of MIP-1alpha-DT390 recombination immunotoxin, and expressing the product in transfection animal body. The experiments show: the recombination immunotoxin MIP-1alpha-DT390 has character to special attack and kill activated Th1 cell while no effect to Th2 and B cells. After curing by the product, the clinical symptom of EAE is released obviously; the pathological section shows that compared with un-cured group, in the cured group, the cerebellum and spinal demyelination lesions reduces, meninges and vein peripheral lymphocyte infiltration decreases.

The invention relates to the technical field of medicines, in particular to the use of pyrazolopyrimidine derivatives in treating autoimmune thyroid diseases. The pyrazolopyrimidine derivatives of the present invention have a good therapeutic effect on autoimmune thyroid diseases, can significantly reduce the levels of thyroid hormones such as T3, T4, FT3, FT4 in serum, and significantly reduce the levels of antibodies TMAb and TGAb in serum, Effectively improve lymphocyte infiltration in thyroid tissue. The therapeutic effect of the pyrazolopyrimidine derivative of the present invention on autoimmune thyroid disease is equivalent to that of thyroxine or prednisone.

The invention provides the application of the CDK7 inhibitor in the preparation of medicine for ulcerative colitis or colon cancer. Through the research on the treatment of mice with experimental ulcerative colitis and the research on the treatment of mice with colon cancer related to experimental ulcerative colitis, the present invention found for the first time that CDK7 inhibitors, especially THZ2, can inhibit the bloody stools accompanied by ulcerative colitis Symptoms, and can reduce the symptoms of diarrhea associated with ulcerative colitis, can effectively treat ulcerative colitis and ulcerative colitis-related colon cancer, help patients reduce body fluid loss, effectively shorten the bloody stool cycle, relieve the severity of bloody stool and The severity of diarrhea can reduce the infiltration of lymphocytes in the colon, reduce the level of inflammation-related proteins, reduce the incidence of tumors, shorten the treatment cycle of patients, and improve the cure rate. its application value.

The embodiment of the invention discloses application of elemonic acid and solid dispersion thereof in preparation of a medicine for treating ulcerative colitis, and belongs to the technical field of medicines. Experiments prove that the elemonic acid can remarkably relieve clinical symptoms of mice with ulcerative colitis, remarkably reduce necrosis of colon tissues of the mice, remarkably relieve damage to colon tissue structures, relieve inflammatory response and reduce lymphocyte infiltration; the levels of TNF-alpha and IL-1beta in colon tissues are obviously reduced, and meanwhile, the expression of TNF-alpha in serum is obviously reduced. The elemonic acid can be used for increasing the expression of tight binding proteins Occludin and claudin-1, protecting intercellular connection and enhancing the resistance of intestinal mucosa barriers of mice to exogenous microorganisms. The elemonic acid provided by the invention can be prepared into a medicine which has a good effect and is used for treating and / or preventing ulcerative colitis, and the dissolution rate of the medicine can be increased by preparing the elemonic acid into the solid dispersion, so that the oral absorption rate of the elemonic acid is increased.