Use of pyrazolopyrimidine derivatives in the treatment of autoimmune thyroid disease

A technology of pyrazolopyrimidine and autoimmunity, which is applied in the field of pyrazolopyrimidine derivatives for the treatment of autoimmune thyroid diseases, can solve problems such as the use of autoimmune thyroid diseases, and achieve expansion of drug selectivity, The effect of extending the range of application

Active Publication Date: 2022-03-08
GUANGXI WUZHOU PHARMA GRP
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are only reports about pyrazolopyrimidine derivatives in the treatment of acute myeloid leukemia and psoriasis, but there is no use in the treatment of autoimmune thyroid diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of pyrazolopyrimidine derivatives in the treatment of autoimmune thyroid disease
  • Use of pyrazolopyrimidine derivatives in the treatment of autoimmune thyroid disease
  • Use of pyrazolopyrimidine derivatives in the treatment of autoimmune thyroid disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Effect of Eat Mouse Apathological Structure and Hormone, Antibody Level

[0037] 1. Experimental animals: ICR mice, female, body mass 18 ~ 22g, purchased in Beijing Virong Lihua Experimental Animal Technology Co., Ltd.

[0038] 2. Experimental materials: The pyrazolipyrimidine derivative is synthesized by inventors. After mixing castor oil and ethanol 1: 1, after 0.22 μm sterile filtration, the ELE solution was obtained, and a pyrazolipyrimidine derivative powder of the present invention was weighed, and the powder was dissolved with ELE solution, and after the powder was completely dissolved, Add a certain volume of sterilized water, mix well to be used. The volume ratio of the ELE solution to sterile water is 1: 3. Pig lead thyroid globulin (PTG, Sigma). Highly iodized solution (0.64 g of potassium iodide is dissolved in 1L distilled water). Preparation containing complete Frego adjuvant: mixed liquid paraffin and emulsifier wool fat, mixed, for incomplete Frego...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the technical field of medicines, in particular to the use of pyrazolopyrimidine derivatives in treating autoimmune thyroid diseases. The pyrazolopyrimidine derivatives of the present invention have a good therapeutic effect on autoimmune thyroid diseases, can significantly reduce the levels of thyroid hormones such as T3, T4, FT3, FT4 in serum, and significantly reduce the levels of antibodies TMAb and TGAb in serum, Effectively improve lymphocyte infiltration in thyroid tissue. The therapeutic effect of the pyrazolopyrimidine derivative of the present invention on autoimmune thyroid disease is equivalent to that of thyroxine or prednisone.

Description

Technical field [0001] The present invention relates to the use of a pharmaceutical technique, particularly a pyrazolipyrimidine derivative in the treatment of autoimmune thyroid disease. Background technique [0002] Autoimmune Thyroid Disease (AITD) accounts for 30% of all its own aggressive diseases, such diseases are organ specific autoimmune diseases. Among them, Chronicly Mphocyticthyroiditis, CLT and Graves Disease (GD) are the most common. The former is also known as Hashimoto Thyroiditis (HT), which is characterized by the existence of high titers in the serum, with the infiltration of thyroid lymphocytes, gradually destroying gland, eventually leading to clinical thyroid dysfunction and Fibrosis of thyroid tissue. It is generally believed that its pathogenesis may be a human or animal having genetic and susceptibility. Under the action of pathogenic factors such as environmental, diet and infection, there is a disorder of immune function due to the defects of immune mon...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61P37/00A61P5/14
CPCA61K31/519A61P37/00A61P5/14
Inventor 陈焕展巫鑫李柏霖钟杰敏赖树生李鑫林艳英黄源春
Owner GUANGXI WUZHOU PHARMA GRP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap