Application of cdk7 inhibitor in preparation of medicine for ulcerative colitis or colon cancer

A colon cancer and inhibitor technology, applied in the application field of preparing ulcerative colitis or colon cancer drugs, can solve the problems of unclear relationship, no CDK7 inhibitor colon cancer treatment, etc., to expand the scope of application and increase the difficulty of treatment , the effect of improving the cure rate
CN110101703BActive Publication Date: 2021-06-11JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2021-06-11

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Abstract

The invention provides the application of the CDK7 inhibitor in the preparation of medicine for ulcerative colitis or colon cancer. Through the research on the treatment of mice with experimental ulcerative colitis and the research on the treatment of mice with colon cancer related to experimental ulcerative colitis, the present invention found for the first time that CDK7 inhibitors, especially THZ2, can inhibit the bloody stools accompanied by ulcerative colitis Symptoms, and can reduce the symptoms of diarrhea associated with ulcerative colitis, can effectively treat ulcerative colitis and ulcerative colitis-related colon cancer, help patients reduce body fluid loss, effectively shorten the bloody stool cycle, relieve the severity of bloody stool and The severity of diarrhea can reduce the infiltration of lymphocytes in the colon, reduce the level of inflammation-related proteins, reduce the incidence of tumors, shorten the treatment cycle of patients, and improve the cure rate. its application value.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and particularly relates to the application of a CDK7 inhibitor in the preparation of ulcerative colitis or colon cancer medicine. Background technique

[0002] Inflammatory bowel disease is mainly divided into ulcerative colitis (UC) and Crohn's disease (CD). Among them, the pathogenesis of ulcerative colitis is unclear, and it often recurs. It is often accompanied by symptoms such as bloody stools and diarrhea. The submucosa of the colon under pathological section observation has a large number of leukocytes infiltrated, which will increase the incidence of colon cancer in the long run. A class of diseases that threaten people's health. At present, there is no specific drug that can cure all patients with ulcerative enteritis.

[0003] At present, the academic circles believe that inflammation is one of the important causes of cancer. Colon cancer associated with ulcerative colitis is mostly...

Claims

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