Application of methylidyne artemisinin in preparation of medicine for treating liver diseases

A technology for methenyl artemisinin and liver disease, which is applied in the field of medicine, can solve problems such as the prevention and treatment of liver disease with no experimental data, and achieve the expansion of clinical application scope, improvement of liver function, and relief of liver disease. damage effect

Inactive Publication Date: 2017-09-15
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing literature and technical materials, there is no experimental data to prove that methine artemisinin has pharmacological activity in the prevention and treatment of liver diseases

Method used

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  • Application of methylidyne artemisinin in preparation of medicine for treating liver diseases
  • Application of methylidyne artemisinin in preparation of medicine for treating liver diseases
  • Application of methylidyne artemisinin in preparation of medicine for treating liver diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Preparation of Methylene Artemisinin Dropping Pills

[0015] Mix 25 g of methine artemisinin with 55 g of polyethylene glycol 4000, heat and melt in a water bath at 80°C, stir at a constant temperature of 80°C for 60 minutes to make the dispersion uniform, and quickly transfer the liquid medicine to a storage tube at a constant temperature of 75°C. The caliber of the dripper is 3.8 / 5.0 mm, the dripping speed is controlled at 60 drops per minute, simethicone oil is used as the coolant, the temperature of the cooling liquid is controlled at 10°C, the weight of the dropping pills is adjusted to 80mg, and the drops are made into pills, and the surface of the dropping pills is Remove the cooling liquid on the surface, and film-coat it, make 1000 drop pills, and pack it separately. Oral administration is suitable for patients with cirrhosis caused by alcohol and hepatitis. 1-3 capsules each time, 2-3 times a day, 30 days as a course of treatment, can be used continuously for...

Embodiment 2

[0017] Preparation of Methylene Artemisinin Tablets

[0018] Take 50g of methine artemisinin, 450g of microcrystalline cellulose, 100g of Starch1500, 10g of magnesium stearate, pass through a 60 mesh sieve and mix evenly, use 75% ethanol as a binder to make a soft material, and granulate through a 24 mesh sieve in 60 Dry at ℃, granulate with 24 mesh sieve, add the prescribed amount of magnesium stearate, mix well, press 1000 tablets, pack in separate packages, and each tablet contains 50 mg of methine artemisinin. Oral, suitable for patients with cirrhosis caused by alcohol and hepatitis. 1-2 tablets each time, 2-3 times a day, 30 days as a course of treatment, can be used continuously for 2-3 courses.

Embodiment 3

[0020] Preparation of Methylene Artemisinin Syrup

[0021] Dissolve 10g of methine artemisinin in 80mL of ethanol and 40mL of propylene glycol solution, then add 0.5mL of orange essence, 3.0g of sodium benzoate, 220mL of purified water, 1g of aspartame, heat and stir for 10min (at a temperature of about 45°C), put Cold, add an appropriate amount of simple syrup to adjust to 1000mL, mix well, divide into 100mL bottles. Oral, suitable for patients with liver cirrhosis caused by alcohol and hepatitis. 5-10mL each time, 1-2 times a day, 30 days as a course of treatment, can be used continuously for 2-3 courses.

[0022] Other pharmaceutical preparations, such as powders, capsules, granules, injections, microcapsules or oral solutions, etc., can be prepared according to conventional methods.

[0023] The application of the methine artemisinin provided in the examples of the present invention in the preparation of drugs for treating liver diseases will be further illustrated throu...

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PUM

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Abstract

The invention discloses an application of methylidyne artemisinin in preparation of a medicine for treating liver diseases. The methylidyne artemisinin is combined with a medicinal carrier to form a medicine preparation, such as dripping pills, tablets, powders, capsules, granules, injections, microcapsules, syrups or oral solutions. The methylidyne artemisinin can reduce serum ALT, serum AST and liver index of liver disease patients, can improve functions of liver, effectively relieves liver damage due to alcoholic liver and hepatitis, can significantly reduce contents of HA, PC III and IV-C in patients and has significant anti-liver cirrhosis effect. The invention develops clinical application range of the methylidyne artemisinin and finds novel medicine sources for treatment on liver diseases, such as the alcoholic liver damage, acute liver damage, liver cirrhosis and the like, and also has advantage on complete utilization of the methylidyne artemisinin.

Description

technical field [0001] The invention belongs to the technical field of medicines and relates to a new application of methine artemisinin, in particular to the application of methine artemisinin in the preparation of medicines for treating liver diseases. Background technique [0002] As one of the most common human diseases, liver disease poses a huge threat to human health, and its prevention and treatment is a major topic of modern medicine. With the improvement of people's living standards, great changes have taken place in the diet structure, the intake of alcohol and fat has increased, and the incidence of alcoholic liver injury is on the rise. Alcohol is mainly metabolized in the liver. Excessive drinking can cause liver cell damage, and in severe cases, it can lead to liver cell necrosis. Alcoholic liver injury is also one of the common causes of cirrhosis. At present, there are more than 7 million patients with liver cirrhosis in our country, and the number of pati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61P1/16
CPCA61K31/366
Inventor 闫雪生刘瑾于蓓蓓孙丹丹
Owner SHANDONG ACAD OF CHINESE MEDICINE
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