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Application of heme in medicine and healthcare food which are capable of improving sleep disorders

A technology for health food and sleep disorders, which is applied in the fields of food, health food, and medicine, and can solve problems such as slow effect, large time-dependent dependence, and cognitive decline

Inactive Publication Date: 2017-10-13
上海康孕企业管理合伙企业(有限合伙)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantages of the above-mentioned western medicine preparations are that they are time-sensitive and highly dependent, and they need to be taken for a long time. However, taking these medicines for a long time will cause a series of adverse reactions, such as drowsiness, dizziness, hangover effect, and cognitive decline. Wait
The toxic and side effects of traditional Chinese medicine preparations are small, but the effect is slow, and it takes a long time to take effect

Method used

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  • Application of heme in medicine and healthcare food which are capable of improving sleep disorders
  • Application of heme in medicine and healthcare food which are capable of improving sleep disorders
  • Application of heme in medicine and healthcare food which are capable of improving sleep disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The safety test of embodiment 1 composition

[0056] This embodiment passes acute toxicity (oral LD 50 ) test, observe the adverse reaction and death caused by oral administration of the test sample once to animals and determine the half-lethal dose.

[0057] 1. Sample

[0058] Take 50 tablets of the sample in the material (hemin 17.5 mg / tablet), a total of 20,000 mg, add distilled water to 25 mL, and mix well to obtain the test sample.

[0059] 2. Subjects

[0060] 20 Kunming mice, 10 males and 10 males, weighing 18-22 grams.

[0061] 3. Experimental conditions

[0062] Room temperature: 22±2°C, relative humidity: 50-70%.

[0063] 4. Test method

[0064] Animals were fasted for 16 hours before the experiment.

[0065] Take 20 animals, 10 males and 10 males, weigh them, and give samples once by gavage at 0.5mL / 20g body weight.

[0066] Observe the poisoning symptoms and death of the experimental animals within one week after giving the samples. Calculate LD 50...

Embodiment 2

[0075] Improvement experiment E1 of the composition of embodiment 2 to sleep disorders

[0076] This example observes and evaluates the effect of applying the following preparations on people over 12 years old with sleep disorders.

[0077] 1 Experimental method

[0078] 1.1 Sample

[0079] Get the sample (hemin 17.5mg / tablet) in the above-mentioned material as the test product; the control product as the placebo.

[0080] 1.2 Subjects

[0081] There were 210 cases of people aged 12-70 with sleep disorders and no other diseases.

[0082] 1.3 Criteria for inclusion of testers

[0083] Volunteer subjects with sleep disorders such as difficulty falling asleep, short sleep time and poor sleep quality were selected.

[0084] 1.4 Exclude testers

[0085] 1.4.1 Patients with heart, liver, kidney and other important organ complications;

[0086] 1.4.2 Combined with other serious primary diseases;

[0087] 1.4.3 Incomplete data cannot accurately determine the curative effect. ...

Embodiment 3

[0118] The improvement experiment E2 of embodiment 3 composition to sleep disorder

[0119] This example observes and evaluates the effect of applying the following preparations on people aged 3-12 with sleep disorders.

[0120] 1 Experimental method

[0121] 1.1 Sample

[0122] Get the sample (hemin 16mg / tablet) in the above-mentioned material as the test product; the control product as the placebo.

[0123] 1.2 Subjects

[0124] There were 120 cases of people aged 3-12 with sleep disorders and no other diseases.

[0125]1.3 Criteria for inclusion of testers

[0126] Volunteer subjects with sleep disorders such as difficulty falling asleep, short sleep time and poor sleep quality were selected.

[0127] 1.4 Exclude testers

[0128] 1.4.1 Patients with heart, liver, kidney and other important organ complications;

[0129] 1.4.2 Combined with other serious primary diseases;

[0130] 1.4.3 Incomplete data cannot accurately determine the curative effect.

[0131] 1.5 Tas...

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Abstract

The invention provides application of heme in medicine, food and healthcare food which are capable of improving sleep disorders, and specifically provides the application of the heme, a derivative thereof, an analogue thereof, a solvate thereof or pharmaceutically acceptable salt thereof. The heme, the derivative thereof, the analogue thereof, the solvate thereof and the pharmaceutically acceptable salt thereof are used for preparing a medicine composition, a preparation, the food or the healthcare food, and the medicine composition, the preparation, the food or the healthcare food can be used for (a) treating or improving the sleep disorders and (b) improving symptoms related to the sleep disorders.

Description

technical field [0001] The invention relates to the fields of medicine, food and health food, and more specifically relates to the application of heme in medicine, food and health food for improving sleep disorders. Background technique [0002] Sleep is an important physiological phenomenon of the human body, and it is extremely important for maintaining normal physiological activities and a healthy mental state of the body. However, with the development of the economy and society and the acceleration of the pace of life, people's life pressure is also increasing, which indirectly affects people's sleep quality, and the number of people suffering from sleep disorders is also increasing year by year, of which insomnia is the most common. [0003] Insomnia is clinically manifested as dull complexion, emaciation, fatigue, forgetfulness, palpitation and other symptoms. Insomnia can cause tiredness and irritability, which can interfere with daily activities. Long-term insomnia...

Claims

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Application Information

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IPC IPC(8): A61K31/555A61P25/20A23L33/10
CPCA23V2002/00A61K31/555A23L33/10A23V2200/31A23V2200/30
Inventor 于茂泉
Owner 上海康孕企业管理合伙企业(有限合伙)
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