Application of cedrol and cedrol derivatives to preparation of drugs for promoting hair growth and relieving hair loss

A technology of hair growth and derivatives, which is applied in hair care, drug combination, pharmaceutical formula, etc. It can solve the problems of unclear active ingredients and no quality control methods of traditional Chinese medicine, so as to meet the needs and promote hair growth.

Active Publication Date: 2017-10-20
辽宁新中现代医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It not only solves the side effects caused by long-term high-dose use of chemical drugs, but also solves the problems of unclear active ingredients and no quality control methods of traditional Chinese medicine.

Method used

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  • Application of cedrol and cedrol derivatives to preparation of drugs for promoting hair growth and relieving hair loss
  • Application of cedrol and cedrol derivatives to preparation of drugs for promoting hair growth and relieving hair loss
  • Application of cedrol and cedrol derivatives to preparation of drugs for promoting hair growth and relieving hair loss

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Example 1: Effect experiment of α-cedrol on normal mouse hair growth

[0075] In this example, normal mice were depilated with rosin and paraffin, and the effect of cedrol according to the present invention on hair growth in normal depilated mice was tested, and the pharmacodynamic effects of continuously applying the reagent on the depilated area for 21 days were tested observe.

[0076] The experimental steps in this embodiment are as follows:

[0077] A. Experimental Animal Feeding and Handling

[0078] The experimental animals were C57BL / 6 mice, weighing 18-22g, purchased from the Experimental Animal Center of Shenyang Pharmaceutical University, observed for three days before the experiment, and selected lively and healthy mice for the experiment. During the experiment, the mice in each group were housed in a quiet environment, fed in separate cages, fed with common feed, and had free access to food and water. Drinking water and feed were changed daily, and the l...

Embodiment 2

[0089] It can be seen from the above table that the cedrol administration group has the effect of promoting hair growth in depilated mice, and there are significant differences in hair length and gross weight between the 40mg / kg cedrol administration group and the blank group. The activity of cedrol high-dose group was slightly stronger than that of minoxidil. Example 2: Effect experiment of β-cedrol on hair growth in chemotherapy-damaged alopecia mice

[0090] The present embodiment adopts normal mice after rosin and paraffin depilation, and on the 8th day after administration, a single dose of cyclophosphamide (150mg / kg, dissolved in 0.9% normal saline freshly prepared before use) is used to test this The effect of the cedrol described in the invention on the hair growth of the damaged alopecia mice was observed on the pharmacodynamics of the depilatory area where the reagent was applied continuously for 21 days.

[0091] The dosing regimen is as follows:

[0092] (1) Blan...

Embodiment 3～6

[0103] Examples 3-6: Effect experiment of cedrol composition on hair growth of normal mice

[0104] In this example, normal mice were depilated with rosin and paraffin, and the effect of cedrol according to the present invention on hair growth in normal depilated mice was tested, and the pharmacodynamic effects of continuously applying the reagent on the depilated area for 21 days were tested observe.

[0105] Dosing regimen is as follows (blank control is 75% ethanol solution):

[0106]

[0107] After depilation, the test drug was applied once a day for 21 consecutive days. On the 22nd day, the rats were killed, the hair length and weight of the rats in the new hair area were measured, and the hair growth of the animals in each group was observed every day. The results are shown in Table 3.

[0108]

[0109]

[0110] In the table: compared with the blank control group, * means P<0.05, which has statistical significance, and ** means P<0.01, which has significant dif...

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Abstract

The invention relates to the technical field of natural products, in particular to an application of cedrol and cedrol derivatives or salts to preparation of drugs for promoting hair growth and relieving hair loss. A test result shows that cedrol can promote hair of a normally unhairing mouse to grow and can effectively relieve unhairing symptoms of the mouse after chemotherapy and safety of drug use is proved. When cedrol is subjected to transdermal administration with a daily dose of 100 mg / kg-400 mg / kg, the hair growing effect is remarkably better than that of a hair growing drug minoxidil which is approved by FDA (Food and Drug Administration) and has appeared on the market of China; when cedrol is subjected to administration with a daily dose of 50 mg / kg-200 mg / kg, the unhairing symptoms can be relieved, and the effect is obvious when compared with that of a blank control group. Cedrol not only has the effects of promoting hair growth and preventing hair loss after chemotherapy, but also has the advantages of being prepared from easily available raw materials, natural, non-irritant and the like, and can be taken as a substitute product of a hair growth medicine with high cost or side effects and a product for preventing hair loss and promoting hair growth. According to the invention, demands of people for hair loss preventing drugs can be met, and troubles of people due to hair loss are eliminated.

Description

technical field [0001] The invention relates to the technical field of natural products, relates to new functions of cedrol and its derivatives, and specifically relates to the application of cedrol and its derivatives in the preparation of medicines for promoting hair growth and alleviating hair loss. Background technique [0002] 1. The chemical structure of cedrol: [0003] [0004] 2. Isolation and structure identification of cedrol in ginger [0005] Supercritical (SFE) ginger extract 40mL was dissolved in the mixed solution of 200mL petroleum ether and anhydrous ether (V 石油醚 :V 无水乙醚 1:9), respectively prepare different concentrations of 5% NaHCO 3 400mL each of 1% NaOH alkali solution, and extract step by step according to the volume ratio of 4:4:3. The extracted aqueous layer is acidified with dilute hydrochloric acid until the pH value is 4-5, extracted with petroleum ether, washed 1-2 times, Petroleum ether was recovered to obtain 30.8 mL of non-phenolic oil ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61P17/14A61P17/08A61K8/34A61Q7/00
CPCA61K8/34A61K31/045A61Q7/00A61K2300/00
Inventor 赵余庆张岩关健陈姗姗
Owner 辽宁新中现代医药有限公司
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