Compositions for alleviating, treating and preventing rheumatoid arthritis

A rheumatoid, composition technology, applied in the directions of drug combinations, anti-inflammatory agents, organic active ingredients, etc., can solve the problems of inapplicable prevention, poor patient compliance, etc., to reduce the burden of drug administration, and improve the limitation of the range of activities or life. The effect of quality reduction

Inactive Publication Date: 2017-10-24
MITSUBISHI GAS CHEM CO INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the treatment of rheumatoid arthritis by intraperitoneal injection of pyrroloquinoline quinone, there is still much

Method used

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  • Compositions for alleviating, treating and preventing rheumatoid arthritis
  • Compositions for alleviating, treating and preventing rheumatoid arthritis
  • Compositions for alleviating, treating and preventing rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Prepare 10 rheumatoid arthritis model rats (body weight 150-170 g). In addition, an aqueous solution of PQQ, VD, and water was prepared so that the dosage of PQQ became 2 mg / kg / day, and the dosage of active vitamin D (hereinafter referred to as "VD") became 100 ng / kg / day. sky. The aqueous solution was orally administered to 10 normal model rats, and 72 hours after that time, the above-mentioned procedure for creating the rheumatoid arthritis model rats was carried out.

[0087] 40 days after the preparation of the rheumatoid arthritis model rats, swelling of the feet of the rats was confirmed. The degree of swelling of the feet was evaluated according to the evaluation method of "rheumatism index" described in "Collagen-induced arthritis". "Nature Protocols" (Nature Protocols) 2,-1269-1275 (2007) evaluated, and classified into 5 grades of 0, 1, 2, 3, 4, and evaluated the degree of swelling of 20 hind limbs of 10 rats. In addition, the higher the number of the classif...

Embodiment 2

[0107] Ten arthritic model rats were prepared according to the method described in the above "Preparation of Rheumatoid Arthritis Model Rats". In addition, an aqueous solution in which PQQ, VD, and water were mixed was prepared so that the dose of PQQ became 2 mg / kg / day and the dose of VD became 100 ng / kg / day. In the method described above in "Preparation of Arthritis Model Rats", the aqueous solution was administered to the arthritis model rats on the 9th day counted from the day when the model was first injected into the rats.

Embodiment 3

[0115] 0.2 g of pyrroloquinoline quinone disodium salt (PQQ) was added to 100 g of ion-exchanged water, and stirred at room temperature for 30 minutes. As a result, all pyrroloquinoline quinone disodium salts were dissolved.

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PUM

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Abstract

An object of the present invention is to provide a composition for alleviating rheumatoid arthritis, a composition for treating rheumatoid arthritis, a composition for preventing rheumatoid arthritis, and methods of use or production thereof. The present invention provides a composition for reducing rheumatoid arthritis containing pyrroloquinoline quinones and active vitamin D.

Description

technical field [0001] The present invention relates to a composition for alleviating rheumatoid arthritis, a composition for treating rheumatoid arthritis, a composition for preventing rheumatoid arthritis, and methods of use or production thereof. In addition, "rheumatoid arthritis", that is, rheumatic arthritis (RA), is a chronic autoimmune disease that mainly involves joint lesions and can involve multiple organs and tissues throughout the body. The term includes articular rheumatism, chronic articular rheumatism, rheumatoid arthritis, and rheumatoid arthritis. Background technique [0002] Inflammation of the joint itself is not a fatal disease, but it is mainly because of the inflammation of the joint and other complications that the patient loses the ability to work and reduces the quality of life. Restriction of the range of activities in daily life and reduction in quality of life due to joint inflammation are particularly serious problems in an aging society. Rhe...

Claims

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Application Information

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IPC IPC(8): A61K31/59A61P19/02A61P29/00A61K31/4745
CPCA61K31/59A61K31/4745
Inventor 温传俊孙奋勇
Owner MITSUBISHI GAS CHEM CO INC
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