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Synthetic method of gentiobiose

A synthetic method and technology of gentiobiose, applied in the direction of disaccharides, chemical instruments and methods, sugar derivatives, etc., can solve the problems of long cycle, high cost, low purity, etc., achieve stable properties, avoid isomerization, Overcoming the effects of the purification process

Active Publication Date: 2017-10-24
BEIJING BIOSYNTHESIS BIOTECH
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Problems solved by technology

[0008] Aiming at the problems of high cost, low purity and long cycle in the current gentiobiose synthesis or natural separation process, the invention provides a high-efficiency gentiobiose synthesis method with high yield, low cost and high product purity. High, suitable for industrial production

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Embodiment Construction

[0035] The present invention will be further described below in conjunction with the examples, but the present invention is not limited by the following examples.

[0036] The synthesis of embodiment gentiobiose

[0037] (1) Add 500 g of glucose, 3 L of pyridine, and 928.4 g of triphenylchloromethane into a dry four-necked flask at room temperature. After the addition, the system is heated to 50° C., heated and stirred for 6 hours, and then the system is cooled to room temperature. Compound 1 In the system, do not separate and directly throw into step (2), the reaction formula is as follows:

[0038]

[0039] (2) Add 1.7 kg of acetic anhydride dropwise to the reaction system in step (1), add 17 g of DMAP after the addition is complete, stir the system overnight at room temperature after the addition, point the plate, and the reaction is complete, pour the system into 3.5 L of ice water, A white solid precipitated and was filtered by suction. After the filtration, the white...

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Abstract

The invention provides a synthetic method of gentiobiose. The synthetic method of the gentiobiose comprises the following steps: taking D-glucose as a starting material; respectively synthesizing into beta-1,2,3,4-tetra-acetylated glucose and glucose-B-glucosinolate; and carrying out coupled reaction and then carrying out deprotection to generate the gentiobiose. The controllability of the technological process is high, isomerization of the product is avoided, the yield of single-step reaction is high, and the gentiobiose is suitable for being produced on a large scale. The separating efficiency of a final product is improved. By the chemical method, large-scale production of the gentiobiose is implemented, a biological-method complicated purification process is overcome, the production period is shortened, the cost is reduced, and the purity of the product is improved.

Description

technical field [0001] The invention relates to a method for synthesizing gentiobiose, which belongs to the field of chemical synthesis of sugars. Background technique [0002] Gentiobiose (CAS No.: 554-91-6) is a functional oligosaccharide with a soft and refreshing bitter taste. It can be used in candies, beverages, and cold drinks to make its sweetness more pure. It is low-calorie, low-calorie Sweet substance, difficult to be broken down by human digestive enzymes. Gentiobiose can promote the proliferation and growth of bifidobacterium probiotics and lactic acid bacteria, thereby improving the condition of the colon, and has important uses in the fields of food and medicine. [0003] At present, the industrial preparation method of gentiobiose is obtained by extracting and transforming from natural raw materials such as bitter almonds, or by biotransformation of β-glucosidase. However, the gentiobiose obtained by these methods requires complex purification, membrane sep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/04C07H1/00
CPCC07H1/00C07H3/04
Inventor 李文举唐鹏飞李秀珍
Owner BEIJING BIOSYNTHESIS BIOTECH
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