A kind of medical multifunctional hemostatic dressing and preparation method thereof

A medical and multi-functional technology, which is applied in the fields of medical formula, medical science, bandages, etc., can solve the problems of single dressing function and inability to meet complex wound care requirements, and achieve the effect of promoting healing and realizing dressing performance requirements

Inactive Publication Date: 2020-03-17
JILIN UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the single function of the current dressing, it cannot meet the nursing requirements of various complex wounds, even if the same wound has different effects on the dressing performance at different healing stages.

Method used

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  • A kind of medical multifunctional hemostatic dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Prepare the multifunctional hemostatic gel dressing for medical use according to the following steps:

[0030] 1) Disperse 10g chitosan-g-N-carboxymethyl-2-thio-4,5-2H imidazolidinone (grafting rate 30%), 6g polyglycolic acid, 3g type I collagen powder in 23ml 0.5% wt of acetic acid aqueous solution, heated to 40 ° C and stirred to dissolve to obtain the first mixed solution;

[0031] 2) Mix 20g of mesoporous nano-hydroxyapatite with 13.5g of 30%wt glutaraldehyde aqueous solution and stir at 60°C to obtain the second mixture;

[0032]3) Then add the second mixed solution to the first mixed solution, stir to disperse, let it stand for degassing, pour it into a mold, and place it at room temperature for 1-2 days to obtain a medical multifunctional hemostatic gel dressing precursor;

[0033] 4) Wash the precursor of the functional hemostatic dressing for medical use to remove residual acetic acid and glutaraldehyde, dry it under reduced pressure at 40°C until the water co...

Embodiment 2

[0038] Prepare the multifunctional hemostatic gel dressing for medical use according to the following steps:

[0039] 1) Disperse 10g chitosan-g-N-carboxymethyl-2-thio-4,5-2H imidazolidinone (grafting rate 32%), 6g polyglycolic acid, 3g type I collagen powder in 23ml 0.5% wt of acetic acid aqueous solution, heated to 40 ° C and stirred to dissolve to obtain the first mixed solution;

[0040] 2) Mix 20g of mesoporous nano-hydroxyapatite with 13.5g of 30%wt glutaraldehyde aqueous solution and stir at 60°C to obtain the second mixture;

[0041] 3) Then add the second mixed solution to the first mixed solution, stir to disperse, let stand to defoam, pour into the mold, and place at room temperature for 1-2 days to obtain the medical multifunctional hemostatic gel dressing precursor;

[0042] 4) Wash the precursor of the functional hemostatic dressing for medical use to remove residual acetic acid and glutaraldehyde, dry it under reduced pressure at 40°C until the water content is...

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Abstract

The invention belongs to the technical field of medical materials, and particularly relates to a medical multifunctional haemostatic wound dressing and a preparation method thereof. According to the invention, the multifunctional haemostatic gel dressing is prepared by using chitosan-g-N-carboxymethyl-2-sulfo-4,5-2H imidazolinone, polyglycolic acid, glutaraldehyde, I-type collagen powder and mesoporous nano hydroxyapatite as raw materials through a cross-linking reaction. The multifunctional haemostatic gel dressing prepared by the invention can take effects of stop bleeding, sterilizing and promoting wound healing, and can meet the requirement of a wound for dressing performance in different healing stages; the chitosan-g-N-carboxymethyl-2-sulfo-4,5-2H imidazolinone is prepared into the gel dressing in a form of the invention, so that an antibacterial effect of the chitosan-g-N-carboxymethyl-2-sulfo-4,5-2H imidazolinone is improved.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a medical multifunctional hemostatic dressing and a preparation method thereof. Background technique [0002] A wound is a breach of the integrity and continuity of the human skin. In daily life, there are many types of wounds, including cuts caused by mechanical factors, burns caused by factors such as electricity, heat, and chemicals, and chronic wounds caused by the patient's physiological morbidity. Various wounds on the surface of the human body are unavoidable and common symptoms in life. The longer the wound healing is delayed, the less likely the scars will disappear after healing. The rapid growth and repair of the surface epithelium is more needed. Therefore, the ideal therapeutic index for all kinds of skin wounds is to control secondary infection and promote rapid wound healing. [0003] In the past, for the care of wounds, one was mainly sele...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/46A61L15/62A61L15/28A61L15/42A61L15/26A61L15/32A61L15/44A61L15/18
CPCA61L15/18A61L15/26A61L15/28A61L15/325A61L15/42A61L15/425A61L15/44A61L15/46A61L15/62A61L2300/232A61L2300/252A61L2300/404A61L2300/412A61L2400/04C08L5/08C08L67/04C08L89/00
Inventor 白晶王衍根
Owner JILIN UNIV FIRST HOSPITAL
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