Flushing fluid containing sorbitol and mannitol and suitable for urologic surgeries

Abstract

The invention relates to the field of medical reagents and discloses a flushing fluid containing sorbitol and mannitol and suitable for urologic surgeries. The flushing fluid is prepared from components as follows: 2.5wt%-2.9wt% of sorbitol, 0.5wt%-0.6wt% of mannitol and the balance of water for injection. The flushing fluid is mainly prepared from sorbitol and mannitol serving as main ingredients, adopts perfusion therapy through a proper urinary system instrument via the urethra and is applicable to flushing in the transurethral resection of the prostate and other urologic surgeries. The flushing fluid has the advantages as follows: 1) the flushing fluid is non-hemolytic; 2) the flushing fluid can also be used for diabetics; 3) the flushing fluid has a good diuretic function; 4) the flushing fluid can prevent blood coagulation in the surgeries, and a good intra-operative view can be kept; 5) the flushing fluid serving as a washing fluid used after the surgeries has a good blood coagulation prevention function; 6) the flushing fluid facilitates rapid excretion of sorbitol due to higher content of mannitol, and the potential risks of the sorbitol liver metabolite, namely, lactic acid are reduced.

Description

technical field [0001] The invention relates to the field of medical reagents, in particular to a sorbitol-mannitol flushing solution suitable for urological surgery. Background technique [0002] Benign prostatic hyperplasia (BPH) is a urinary disorder caused by an enlarged prostate, with a high incidence in older men. Common symptoms of BPH include dysuria, weakness, urgency, and frequent urination, including at night, which seriously affect the patient's quality of life. According to the relevant data of the National Institutes of Health, few people have BPH symptoms before the age of 40, but its incidence will continue to increase with age, more than half of men over 60 years old and 90% of men over 70 years old. BPH symptoms. According to reports by Berry et al in the United States, the incidence of BPH in men over 40 years old is 20%, 50% over 60 years old, and as high as 83% in 80 years old; a group of autopsy reports from the Institute of Urology, Peking University...

AI Technical Summary

Problems solved by technology

Disadvantages are: ① Poor transparency, affecting observation

② High viscosity makes gloves sticky and affects operation

In addition, according to recent studies, the number of receptors on the insulin target cell membrane and the affinity for insulin in the elderly are both reduced, so that the binding force is reduced and relative insulin deficiency is prone to occur.