A kind of musk hemorrhoid suppository and preparation method thereof

A technology for musk hemorrhoids and artificial musk, which is applied in the directions of suppository delivery, pharmaceutical formulations, and non-active ingredients medical preparations, etc., can solve problems such as discomfort in patients, achieve excellent penetration effect, avoid local toxic effects, and have stable properties. Effect

Active Publication Date: 2020-07-28
MAYINGLONG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The suppositories used to treat anorectal diseases on the market generally contain a large amount of mineral medicine and borneol. When the product is stored at room temperature, a white frost-like substance is formed on the surface of the suppository. feeling of discomfort

Method used

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  • A kind of musk hemorrhoid suppository and preparation method thereof
  • A kind of musk hemorrhoid suppository and preparation method thereof
  • A kind of musk hemorrhoid suppository and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0049] A musk hemorrhoid suppository, in parts by weight, the musk hemorrhoid suppository is a suppository made from the following raw materials:

[0050]

[0051]

[0052] The improved mixed fatty acid glyceride (stearic acid) is a suppository made of raw materials with the following weight ratio:

[0053]

[0054] The method for preparing the improved mixed fatty acid glyceride (stearin) includes the following steps:

[0055] A. Add beeswax, lauric acid, palmitic acid, stearic acid, and glycerin to the esterification reactor;

[0056] B. Add a quantitative catalyst strong acid to the reactor, heat it to 70°C to melt it, and start stirring at the same time;

[0057] C. Purge nitrogen, continue to heat up to 180~190℃, react for about 5 hours;

[0058] D. There is continuous water production during the reaction. By measuring the amount of water removed, when the amount of water is close to the theoretical value, measure the acid value and hydroxyl value, and calculate the esterification c...

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PUM

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Abstract

The invention discloses a musk hemorrhoids suppository and a preparation method thereof. The suppository is prepared from bezoar, pearls, musk, radix notoginseng, Chinese gall, borneol, herba belladonnae fluid extract, calamine, laurocapram, wool fat and improved mixed fatty glyceride (stearin). The preparation method comprises the following specific steps: (A) pulverizing the pearls, the radix notoginseng and the Chinese gall; (B) mixing the herba belladonnae fluid extract and the calamine, and drying; (C) mixing the mixture with pearl powder, radix notoginseng powder, Chinese gall powder, the bezoar, artificial musk and the calamine; (D) pulverizing the medicine powder to obtain raw powder; (E) heating the laurocapram, the wool fat and the improved mixed fatty glyceride (stearin), adding the borneol, stirring and dissolving; cooling; adding the raw powder and mixing; cooling to obtain the suppository. In the invention, the formula is reasonable, the application is convenient, the phenomenon of surface frosting during storage of the suppository granules is avoided, and the stability of external properties of a product is improved.

Description

Technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a musk hemorrhoid suppository mainly used for treating various types of hemorrhoids, and a new preparation method of the musk hemorrhoid suppository. Background technique [0002] At present, there are many drugs used to treat anorectal diseases. Chemically synthesized drugs are unsatisfactory due to their clinical efficacy and toxic side effects. Traditional Chinese medicine preparations have received unanimous praise from experts and patients due to their remarkable efficacy and low side effects. The suppositories used to treat anorectal diseases on the market generally contain a large amount of mineral medicine and borneol. When the product is stored at room temperature, a white creamy substance is formed on the surface of the suppository. Although it does not affect the quality and efficacy of the product, it will bring certain effects to patients. Feel uncomfortable. [...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/81A61K9/02A61K47/14A61K47/44A61K47/22A61P9/14A61K35/64A61K35/618A61K35/55A61K35/413A61K33/30A61K31/045
CPCA61K9/02A61K31/045A61K33/30A61K35/413A61K35/55A61K35/618A61K35/63A61K36/258A61K36/81A61K47/14A61K47/22A61K47/44A61K2300/00
Inventor 田正军喻红刘保国周秋松
Owner MAYINGLONG PHARMA GROUP
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