Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Multifunctional auxiliary material composition for oral fast-release tablet, and preparation method of oral fast-release tablet

An immediate-release tablet, multifunctional technology, applied in the field of pharmaceutical preparations, to achieve the effect of natural taste, good fluidity and compressibility

Inactive Publication Date: 2017-12-26
杨永新 +1
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the product formula contains some drugs or active ingredients with poor compressibility, and the ratio is high, the problem of compressibility will become more prominent, and it is more challenging to realize the large-scale production process

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Multifunctional auxiliary material composition for oral fast-release tablet, and preparation method of oral fast-release tablet
  • Multifunctional auxiliary material composition for oral fast-release tablet, and preparation method of oral fast-release tablet
  • Multifunctional auxiliary material composition for oral fast-release tablet, and preparation method of oral fast-release tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022] In the preparation method, all the components in the prescription are passed through a 20-mesh sieve, and then all the components except magnesium stearate are mixed uniformly, and the prescription amount of magnesium stearate is added before tableting, and the mixture is continued for 2 minutes. 1000 iron-forming folic acid orally disintegrating tablets, each containing 8 mg of iron and 400 micrograms of folic acid.

[0023] The quality of the iron folic acid orally disintegrating tablet is smooth and shiny. The hardness is 4.5Kg, it disintegrates completely within 20 seconds in the mouth, the taste is cool, sweet and sour, without gritty feeling.

Embodiment 2

[0025] prescription

[0026]

[0027] Preparation method: All the ingredients in the prescription are passed through a 20-mesh sieve, and then all the ingredients except magnesium stearate are mixed uniformly. The prescription amount of magnesium stearate is added before the tableting and the mixture is continued for 2 minutes, and the tablet is compressed. 1000 pieces of collagen orally disintegrating tablets, each containing 200 mg of collagen.

[0028] The quality of the collagen orally disintegrating tablets obtained is smooth and shiny. The hardness is 5.1Kg, it disintegrates completely within 36 seconds in the mouth, and the taste is cool, sweet and sour, without gritty feeling.

Embodiment 3

[0030] prescription

[0031]

[0032]

[0033] In the preparation method, all the components in the prescription are passed through a 20-mesh sieve, and then all the components except magnesium stearate are mixed uniformly, and the prescription amount of magnesium stearate is added before tableting, and the mixture is continued for 2 minutes. 1000 tablets of vitamin C orally disintegrating tablets, each containing 60 mg of vitamin C.

[0034] The quality obtained vitamin C orally disintegrating tablets have a smooth and shiny appearance. The hardness is 4.5Kg, it disintegrates completely within 20 seconds in the mouth, the taste is cool, sweet and sour, without gritty feeling.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
hardnessaaaaaaaaaa
hardnessaaaaaaaaaa
Login to View More

Abstract

The invention relates to a multifunctional auxiliary material composition for a oral fast-release tablet, and a preparation method of the oral fast-release tablet, and belongs to the field of medicine preparations. The auxiliary material composition comprises, by mass, 0.1-80% of a sugar alcohol filler, 0-20% of a powdered sugar filler, 0-20% of other fillers, 5-20% of a disintegrating agent, 0.1-5% of a lubricant, 0.1-5% of a flavoring, and 0-2% of a flow aid. The multifunctional auxiliary material has good fluidity and compressibility, can be applied to a powder direct-tabletting technology, is suitable for preparing various oral fast-release tablets of medicines and health foods through granulation and tabletting, and is especially suitable for oral disintegrating tablets, chewing tablets, buccal tablets, sublingual tablets, dispersing tablets and other dosage forms, and the auxiliary material and the preparation method are suitable for industrial large-scale production, and provide very good auxiliary material and technology choices for the preparation of oral fast-release tablets having excellent mouthfeel, stable quality and stable process.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical preparations, relates to a multifunctional adjuvant composition of an oral quick-release tablet, and also relates to a preparation method for preparing an oral quick-release tablet using the multifunctional adjuvant. Background technique [0002] Tablets are currently the most widely used dosage form in medicines or health foods. They have the advantages of stable quality, accurate dosage, convenient taking and carrying, high production efficiency and low production cost. At the same time, its application is limited to a certain extent because of its large disintegration time difference, low bioavailability, and difficulty in swallowing by some people or patients. Especially for children, swallowing tablets or capsules of medicines or health foods has always been a challenging problem. Poor taste and difficulty in swallowing will reduce the compliance of children with medication, which will directly affe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/26A61K47/38A61K31/519A61K38/01A61K36/736A61K31/194A61K31/375
Inventor 宋辉
Owner 杨永新
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com