Antibacterial medical ultrasonic coupling agent and preparation method thereof

An ultrasonic coupling agent and coupling agent technology, applied in echo/ultrasonic imaging agents, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problems affecting ultrasonic technical indicators, allergic reactions of skin and mucous membranes, and strong irritation and corrosion problems, to achieve the effect of promoting wound healing, expanding the antibacterial spectrum, and strong antibacterial ability

Active Publication Date: 2018-01-30
上海宝阳医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These commonly used high-efficiency disinfectants also have the following defects: 1. Disinfectants can interact with pathogens, and after contacting with the skin, the residues are harmful to the human body, especially in contact with the cavity, mucous membranes, etc., which are highly irritating and corrosive , and even easily cause allergies, teratogenicity, carcinogenicity and other phenomena
For example, methyl and propyl benzoate antibacterial preservatives are known to be effective against mold and yeast, but frequent use can cause skin and mucous membrane allergic reactions, and hydroxybenzaldehyde has been considered by the World Health Organization as an unidentifiable carcinogen
2. The chemical properties of the disinfectant are active, and when in contact with the probe, it has a strong corrosive effect, which affects the service life of the probe; 3. The common disinfectant is compatible with the coupling agent, which has an antagonistic effect and is easy to form white suspended particles, which affects the ultrasonic performance. Technical indicators, while the patient's comfort is reduced after use
Does not meet the requirements for ultrasound

Method used

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  • Antibacterial medical ultrasonic coupling agent and preparation method thereof
  • Antibacterial medical ultrasonic coupling agent and preparation method thereof
  • Antibacterial medical ultrasonic coupling agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] prescription:

[0045]

[0046] The preparation method of the ultrasonic coupling agent of the present embodiment, its steps are as follows:

[0047] Dissolve ε‐polylysine, natamycin, glycerol, small molecule collagen, and triethanolamine in purified water, stir until uniform, add Carbomer 940, stir well, add acetic acid solution (0.5mol / L-1.0mol / L) to adjust the pH value of the system to 6.0-6.5, vacuum degassing, sub-packaging under purified conditions, sealing, marking, and packing to obtain the finished product.

Embodiment 2

[0049] prescription:

[0050]

[0051]

[0052] The preparation method of the ultrasonic coupling agent of the present embodiment, its steps are as follows:

[0053] Dissolve ε‐polylysine, natamycin, glycerol, small molecule collagen, and triethanolamine in purified water, stir until uniform, add Carbomer 940, stir well, add acetic acid solution (0.5mol / L‐1.0mol / L) to adjust the pH value of the system, control the pH value of the whole system between 6.0 and 6.5, vacuum degassing, subpackage under purified conditions, seal, mark, and pack to obtain the finished product.

Embodiment 3

[0055] prescription:

[0056]

[0057] The preparation method of the ultrasonic coupling agent of the present embodiment, its steps are as follows:

[0058] Dissolve ε‐polylysine, natamycin, glycerol, small molecule collagen, and triethanolamine in purified water, stir until uniform, add Carbomer 940, stir well, add acetic acid solution (0.5mol / L‐1.0mol / L) to adjust the pH value of the system, control the pH value of the whole system between 6.0 and 6.5, vacuum degassing, subpackage under purified conditions, seal, mark, and pack to obtain the finished product.

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Abstract

The invention discloses an antibacterial medical ultrasonic coupling agent, which is prepared from bioactive antibacterial ingredients (Epsilon-polylysine and natamycin), small molecular collagen, triethanolamine, glycerol, Carbomer 940, purified water and the like. The invention also discloses a preparation method of the coupling agent. The coupling agent has the advantages of concurrent disinfection effect, non-toxicity, non-irritating and non-allergic performance and ultrahigh safety; meanwhile, the effects of moisturizing the skin and promoting the injured skin restoration are achieved; the product compatibility is simple; the performance is stable; the biocompatibility is good; the cost is lo; and the preparation process is simple.

Description

technical field [0001] The invention belongs to the technical field of medical ultrasonic coupling agent, and in particular relates to an antibacterial medical ultrasonic coupling agent and a preparation method thereof. Background technique [0002] Medical couplant is a necessary medium in the process of ultrasonic diagnosis and treatment. It is used to eliminate the air film between the skin and the probe, which can effectively prevent air from entering, so that the ultrasonic wave can smoothly enter the body under test, thereby obtaining a clearer image. Ultrasound probes are highly sensitive medical instruments, which are easily damaged by improper operation or contact with some incompatible chemical disinfectants. After use in most hospitals in China, they are simply wiped and not thoroughly disinfected. Ultrasonic probes are frequently used in clinical work, directly in contact with the patient's skin and cavity, and carry many types of bacteria. According to relevant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K38/39A61P31/04A61P17/02A61P17/00A61K31/16A61K31/7048
Inventor 李捷
Owner 上海宝阳医疗器械有限公司
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