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Clarification technology and quality control method of medicinal composition having acne treatment effect

A quality control method and composition technology, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effect of avoiding overlap

Inactive Publication Date: 2018-02-02
GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] At present, there is no domestic and foreign use of the composition of Pearl grass, Jin Tiesuo, Tianjihuang, Xinyi Runnan, Primrose Rhododendron, Tudangshen, Yuanbaocao, Xiangmianye, Jindeng, Malan and Viburnum fern for the treatment of acne. Related reports

Method used

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  • Clarification technology and quality control method of medicinal composition having acne treatment effect
  • Clarification technology and quality control method of medicinal composition having acne treatment effect
  • Clarification technology and quality control method of medicinal composition having acne treatment effect

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Embodiment Construction

[0067] A clarification process and a quality control method of a pharmaceutical composition with the effect of treating acne according to the present invention, the clarification process is carried out as follows:

[0068] Clarification process and content of each component

[0069] (1) Preparation of clarifying agent: Type II ZTCl+1 natural clarifying agent consists of two components, A and B. Component A: Precisely measure 1.0g of component A, add a small amount of distilled water, stir to form a paste, then add distilled water to prepare 100mL of viscose, swell for 24 hours, and filter with double gauze. Component B: Precisely measure 1.0g of component B, add a small amount of acetic acid solution with a volume fraction of 1%, stir it into a paste, then add 1% acetic acid solution to prepare 100mL viscose solution, swell for 24 hours, use Double-layer gauze filter, that is.

[0070] (2) Adding order of clarifiers A and B: According to the instructions, ZTC natural clarifi...

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Abstract

The invention discloses a clarification technology and a quality control method of a medicinal composition having an acne treatment effect. The medicinal composition comprises Underleaf Pearl, Psammosilene tunicoides, Hypericum japonicum Thunb., Machilus wangchiana, Rhododendron primuliflorum Bur. et Franch., Root of Java Campanumoea, Hypericum sampsonii Hance, Lindera caudate, Calyx seu fructus Physalis, Indian kalimeris herb and Matteuccia struthiopteris. The clarification technology is concretely characterized in that medicinal composition extract is clarified by a type II ZTC 1+1 natural clarificant. The quality control method concretely comprises the following steps: carrying out thin-layer chromatography on the Underleaf Pearl, Psammosilene tunicoides, Lindera caudate, Calyx seu fructus Physalis and Indian kalimeris herb, and determining the content of vincetoxicoside, hyperoside, catechin, hypericin, lobetyolin and beta-ecdysone in the medicinal composition through high performance liquid chromatography. The clarification technology and the quality control method have the advantages of less device investment, simple operating process, overcoming of the defects of large alcohol consumption, tedious ethanol recovery, and complex determination process of multiple components in medicines of traditional alcohol precipitation methods, and improvement of the controllability ofthe quality standard of the medicinal composition.

Description

technical field [0001] The present invention uses a clarification process using a natural clarifier and a modern analysis and detection instrument to detect traditional Chinese medicine preparations. The technical field relates to a clarification process and a quality control method for a pharmaceutical composition with the effect of treating acne. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous glands, with an incidence rate of 70-87%, and its psychological and social impact on adolescents exceeds that of asthma and epilepsy. (Chinese Acne Treatment Guidelines Expert Group. Chinese Acne Treatment Guidelines (2014 Revision) [J]. Journal of Clinical Dermatology, 2015, 44(1): 52-57) There are many causes of acne, mainly related to elevated androgen levels , increased sebum secretion, abnormal keratinization of the pilosebaceous duct, Propionibacterium acnes infection and secondary inflammatory response. The basic process of acne ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P17/10G01N30/02G01N30/06G01N30/90
CPCA61K36/12A61K36/28A61K36/34A61K36/36A61K36/38A61K36/42A61K36/45A61K36/47A61K36/54A61K36/81A61K2236/33A61K2236/51A61K2236/53A61K2236/55G01N30/02G01N30/06G01N30/90A61K2300/00
Inventor 王恩瀚陈文龙陈汉坤
Owner GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD
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