Preparation method of fibroin antibacterial hand sanitizer

An antibacterial hand sanitizer and silk protein technology, applied in the direction of antibacterial drugs, local antibacterial agents, skin care preparations, etc., can solve the problems of easy contamination with dirt and bacteria, easy slipping, dullness, etc. Good moisture retention, gentle effect on the skin

Inactive Publication Date: 2018-02-23
关亚玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although scented soap has good decontamination ability, it is easy to slip when used, and it will be softened and consumed naturally when it encounters water and high temperature; it is alkaline, and it will make the skin dry and dull after washing hands, especially it is easy to be contaminated with dirt and dirt on hands. Bacteria, becoming a secondary pollution source

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A preparation method of silk protein antibacterial hand sanitizer, comprising the following steps:

[0019] Step 1, in parts by weight, add 1 part of cocoon to 50 parts of water, boil for 15 minutes, take out the silk, soak it in deionized water, wash it, and dry it at 50-60°C to obtain degummed silk;

[0020] Step 2, in parts by weight, place 10 parts of degummed silk in 80 parts of 3wt.% lithium bromide solution, heat to 70°C and stir for 5 hours, after cooling, filter and dialyze with deionized water to obtain silk fibroin aqueous solution;

[0021] Step 3, concentrating the silk fibroin aqueous solution with a nanofiltration membrane to a volume of 1 / 3 to obtain a silk fibroin concentrate;

[0022] Step 4, in parts by weight, mix 0.5 parts of isopropyl myristate, 5 parts of Tween-80, and 1.2 parts of glycerin, add 10 parts of silk fibroin concentrate under stirring conditions, and disperse at 300-500prm for 10-15min , to obtain silk fibroin emulsion;

[0023] Step...

Embodiment 2

[0025] A preparation method of silk protein antibacterial hand sanitizer, comprising the following steps:

[0026] Step 1, in parts by weight, add 1 part of cocoon to 70 parts of water, boil for 18 minutes, take out the silk, soak it in deionized water, wash it, and dry it at 50-60°C to obtain degummed silk;

[0027] Step 2, in parts by weight, place 10 parts of degummed silk in 60 parts of 4wt.% lithium bromide solution, heat to 75°C and stir for 4.5 hours, after cooling, filter and dialyze with deionized water to obtain silk fibroin aqueous solution;

[0028] Step 3, concentrating the silk fibroin aqueous solution with a nanofiltration membrane to a volume of 1 / 3 to obtain a silk fibroin concentrate;

[0029] Step 4, in parts by weight, mix 0.8 parts of isopropyl myristate, 8 parts of Tween-80, and 1.5 parts of glycerin, add 14 parts of silk fibroin concentrate under stirring conditions, and disperse at 300-500prm for 10-15min , to obtain silk fibroin emulsion;

[0030] St...

Embodiment 3

[0032] A preparation method of silk protein antibacterial hand sanitizer, comprising the following steps:

[0033] Step 1, in parts by weight, add 1 part of silkworm cocoon to 100 parts of water, boil for 15 minutes, take out the silk, soak it in deionized water, wash it, and dry it at 50-60°C to obtain degummed silk;

[0034] Step 2, in parts by weight, place 10 parts of degummed silk in 50 parts of 5wt.% lithium bromide solution, heat to 80° C. and stir for 4 hours, after cooling, filter and dialyze with deionized water to obtain silk fibroin aqueous solution;

[0035] Step 3, concentrating the silk fibroin aqueous solution with a nanofiltration membrane to a volume of 1 / 2 to obtain a silk fibroin concentrate;

[0036] Step 4, in parts by weight, mix 1.2 parts of isopropyl myristate, 10 parts of Tween-80, and 1.8 parts of glycerin, add 20 parts of silk fibroin concentrate under stirring conditions, and disperse at 300-500prm for 10-15min , to obtain silk fibroin emulsion; ...

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PUM

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Abstract

The invention provides a preparation method of a fibroin antibacterial hand sanitizer. According to the method, firstly, silkworm cocoons are added into water, boiling degumming is conducted, degummedsilk is placed in a lithium bromide solution for heating dissolution, after the mixed solution is cooled, filtered, subjected to dialysis with deionized water, and concentrated with a nanofiltrationmembrane, and a silk fibroin concentration solution is obtained; secondly, isopropyl myristate, tween-80 and glycerol are taken and mixed with the silk fibroin concentration solution, and dispersion is conducted to obtain a silk fibroin emulsion; finally, alpha-alkenyl sulphonate, coconut oil monoethanolamide, glycerin cocoate, citric acid and ammonium chloride are added to the silk fibroin emulsion and mixed, and the hand sanitizer is obtained. The hand sanitizer not only has excellent decontamination performance and antibacterial performance, but also has a good moisture retention effect, and is mild and harmless to the skin.

Description

technical field [0001] The invention belongs to the technical field of daily necessities, and in particular relates to a preparation method of silk protein antibacterial hand sanitizer. Background technique [0002] Hand washing articles belong to a kind of skin cleanser, in the past a long period of time in our country, people use scented soap to wash their hands always. Although scented soap has good decontamination ability, it is easy to slip when used, and it will be softened and consumed naturally when it encounters water and high temperature; it is alkaline, and it will make the skin dry and dull after washing hands, especially it is easy to be contaminated with dirt and dirt on hands. Bacteria become a secondary pollution source. Changes in public consumption concepts have made hand sanitizers gradually become a substitute for traditional hand sanitizers in recent years, and are widely used in public places such as families, hotels, restaurants, airports, stations,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61Q19/10A61Q17/00A61P31/02A61P31/04
CPCA61K8/64A61Q17/005A61Q19/10
Inventor 关亚玲
Owner 关亚玲
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